Factors Effecting the Decompensation of Chronic Heart Failure in the Elderly

Ларина, В. Н.; Барт, Б. Я.; Vartanyan, E. A.

doi:10.20996/1819-6446-2013-9-1-15-24

Cited by 2 publications

(4 citation statements)

References 25 publications

(46 reference statements)

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“…Of the 12 studies, 1 reported their data as both categorical and continuous variables, 8 reported data as categorical variables, and 3 reported data as continuous variables. Pooled data from nine studies reporting the estimates as categorical variables showed that hyperuricaemia was associated with an increased risk of the composite of death or cardiac events in HF patients (HR 1.39, 95% CI 1.18–1.63) but substantial statistical heterogeneity was found (I 2 = 66.3%) ( Figure C ) . Although every 1 mg/dL increase in serum uric acid was associated with a 28% increase in the risk of the composite endpoint from pooling the four studies reporting the estimates as continuous variables, the calculation of risk did not reach statistical significance (HR 1.28, 95% CI 0.97–1.70) .…”

Section: Resultsmentioning

confidence: 97%

“…In total, 33 studies were retrieved after a detailed review of 1745 citations. Among these, 5 studies reported on the incidence of HF, and 28 studies reported on the adverse outcomes of HF patients.…”

Section: Resultsmentioning

confidence: 99%

“…Four studies were from Japan, five studies were from China, two studies were from the UK, two studies were from Poland, two studies were from Italy, two studies were from the Czech Republic, two studies were from Israel, two studies were from several countries, and the others were from the USA, Germany, Spain, Slovenia, South Korea, Russia, and Turkey, respectively. Twenty studies focused on the adverse outcomes of all‐cause mortality, 12 studies on the composite of death or cardiac events, 3 studies were on cardiovascular mortality, and 2 studies were on AF. Eighteen studies adjusted the impact of confounders when assessing the association of serum uric acid with the risk of HF.…”

Section: Resultsmentioning

confidence: 99%

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Uric acid and risk of heart failure: a systematic review and meta‐analysis

Huang

et al. 2013

European J of Heart Fail

272

162

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AimsWe aimed to perform a systematic review and meta-analysis to assess the association between serum uric acid and incident heart failure (HF)/prognosis of HF patients. Methods and resultsA systematic electronic literature search was conducted in Embase (Ovid SP, from 1974 to May 2013), Medline (Ovid SP, from 1946 to May 2013), and the Chinese Biomedical Literature Database (CBM, from 1978 to May 2013) to identify studies reporting on the association between serum uric acid and HF. Either a random effects model or a fixed effects model was used for pooling data. Five studies reporting on incident HF and 28 studies reporting on the adverse outcomes of HF patients were included. The results showed that hyperuricaemia was associated with an increased risk of incident HF [hazard ratio (HR) 1.65, 95% confidence interval (CI) 1.41-1.94], and the risk of all-cause mortality (HR 2.15, 95% CI 1.64 -2.83), cardiovascular mortality (HR 1.45, 95% CI 1.18 -1.78), and the composite of death or cardiac events (HR 1.39, 95% CI 1.18-1.63) in HF patients. For every 1 mg/dL increase in serum uric acid, the odds of development of HF increased by 19% (HR 1.19, 95% CI 1.17-1.21), and the risk of all-cause mortality and the composite endpoint in HF patients increased by 4% (HR 1.04, 95% CI 1.02-1.06) and 28% (HR 1.28, 95% CI 0.97-1.70), respectively. Subgroup analyses supported the positive association between serum uric acid and HF. ConclusionsElevated serum uric acid is associated with an increased risk of incident HF and adverse outcomes in HF patients.--

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Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Uric acid and risk of heart failure: a systematic review and meta‐analysis

Huang

et al. 2013

European J of Heart Fail

272

162

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“…Thus, we did not include those studies in our analysis. Finally, there were 74 studies 27–100 and 38 studies 85,101–137 in which we could estimate RRs for new‐onset and recurrent HF, respectively, in relation to DM. One study 85 examined both new‐onset and recurrent HF risk.…”

Section: Resultsmentioning

confidence: 99%

Diabetes mellitus and risk of new‐onset and recurrent heart failure: a systematic review and meta‐analysis

et al. 2020

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Despite mounting evidence of the positive relationship between diabetes mellitus (DM) and heart failure (HF), the entire context of the magnitude of risk for HF in relation to DM remains insufficiently understood. The principal reason is because new-onset HF (HF occurring in participants without a history of HF) and recurrent HF (HF re-occurring in patients with a history of HF) are not discriminated. This meta-analysis aims to comprehensively and separately assess the risk of new-onset and recurrent HF depending on the presence or absence of DM. We systematically searched cohort studies that examined the relationship between DM and new-onset or recurrent HF using EMBASE and MEDLINE (from 1 Jan 1950 to 28 Jul 2019). The risk ratio (RR) for HF in individuals with DM compared with those without DM was pooled with a random-effects model. Seventy-four and 38 eligible studies presented data on RRs for new-onset and recurrent HF, respectively. For new-onset HF, the pooled RR [95% confidence interval (CI)] of 69 studies that examined HF as a whole [i.e. combining HF with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF)] was 2.14 (1.96-2.34). The large between-study heterogeneity (I 2 = 99.7%, P < 0.001) was significantly explained by mean age [pooled RR (95% CI) 2.60 (2.38-2.84) for mean age < 60 years vs. pooled RR (95% CI) 1.95 (1.79-2.13) for mean age ≥ 60 years] (P < 0.001). Pooled RRs (95% CI) of seven and eight studies, respectively, that separately examined HFpEF and HFrEF risk were 2.22 (2.02-2.43) for HFpEF and 2.73 (2.71-2.75) for HFrEF. The risk magnitudes between HFpEF and HFrEF were not significantly different in studies that examined both HFpEF and HFrEF risks (P = 0.86). For recurrent HF, pooled RR (95% CI) of the 38 studies was 1.39 (1.33-1.45). The large between-study heterogeneity (I 2 = 80.1%, P < 0.001) was significantly explained by the proportion of men [pooled RR (95% CI) 1.53 (1.40-1.68) for < 65% men vs. 1.32 (1.25-1.39) for ≥65% men (P = 0.01)] or the large pooled RR for studies of only participants with HFpEF [pooled RR (95% CI), 1.73 (1.32-2.26) (P = 0.002)]. Results indicate that DM is a significant risk factor for both new-onset and recurrent HF. It is suggested that the risk magnitude is large for new-onset HF especially in young populations and for recurrent HF especially in women or individuals with HFpEF. DM is associated with future HFpEF and HFrEF to the same extent.

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Factors Effecting the Decompensation of Chronic Heart Failure in the Elderly

Cited by 2 publications

References 25 publications

Uric acid and risk of heart failure: a systematic review and meta‐analysis

Uric acid and risk of heart failure: a systematic review and meta‐analysis

Diabetes mellitus and risk of new‐onset and recurrent heart failure: a systematic review and meta‐analysis

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