With the development of society and the aggravation of the trend of population aging, the elderly with grandchildren has become an increasingly common phenomenon. These elderly people often need to use baby carriages in the process of taking care of their grandchildren. However, the factors affecting the comfort of the elderly with grandchildren using strollers have not been fully studied. The purpose of this study is to explore the factors affecting the comfort of strollers used by the elderly with grandchildren, in order to provide a theoretical basis for the design and improvement of related products. This study adopts the methods of literature analysis, field investigation and experimental research. This paper makes a comprehensive analysis of the comfort of the baby carriage used by the elderly with grandchildren. First of all, through literature analysis, the research results on the comfort and influencing factors of the elderly with grandchildren and baby carriages at home and abroad are sorted out, and the theoretical basis and research framework of the study are clarified. Secondly, through the field survey method, the actual situation of the use of baby carriages by the elderly with grandchildren is collected, and their needs and troubles in the use process are understood. Finally, through the experimental research method, the scene of the elderly with grandchildren using baby carriages is simulated under laboratory conditions. The physiological and psychological indexes were measured, and the main factors affecting the comfort were analyzed.