Factors influencing cardiometabolic risk profile in patients with psoriasis

Curcó, N.; Barriendos, Nuria; Barahona, María José; Arteaga, Carmen; García, Mercedes; Yordanov, Stanislav; Barrera, Olimpia De La; Prat, C.; Vives, P.; Giménez, Núria

doi:10.1111/ajd.12577

Cited by 17 publications

(21 citation statements)

References 21 publications

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“…These authors also classified psoriasis severity depending on their treatment and moderate–severe psoriasis prevalence calculated is similar, so we think that geographical or cultural factors could explain these differences. Curcó et al . could neither find an association, even though a link between psoriasis severity and diabetes mellitus was described.…”

Section: Discussionmentioning

confidence: 89%

“…Our data corroborate the increased risk of suffering a major cardiovascular event in patients with psoriasis, both ischaemic heart disease (OR 1.87, 95% CI: 1.63–2.13, P < 0.001) and cerebrovascular disease (OR 1.55, 95% CI: 1.29–1.86, P < 0.001). The hypothesis that a chronic inflammatory disease such as psoriasis may have an independent role in the pathogenesis of a cardiovascular event is not unreasonable, and many authors have linked systemic inflammatory diseases such as rheumatoid arthritis, systemic lupus erythematosus or inflammatory bowel disease with an increased cardiovascular risk . More publications should be performed to elucidate this topic.…”

Section: Discussionmentioning

confidence: 99%

“…22 Our data corroborate the increased risk of inflammatory bowel disease with an increased cardiovascular risk. 20,[23][24][25] More publications should be performed to elucidate this topic.…”

Section: Discussionmentioning

confidence: 99%

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Psoriasis, metabolic syndrome and cardiovascular risk factors. A population‐based study

Fernández‐Armenteros

Gómez‐Arbonés

Buti‐Soler

et al. 2018

Acad Dermatol Venereol

118

100

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We found statistically significant differences in relation to the prevalence of cardiovascular risk factors, MS and major cardiovascular events in psoriatic patients. However, differences were not seen between psoriasis severity groups. Our work reinforces the need for a multidisciplinary approach and close monitoring of cardiovascular risk factors in these patients to prevent a cardiovascular event.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

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Psoriasis, metabolic syndrome and cardiovascular risk factors. A population‐based study

Fernández‐Armenteros

Gómez‐Arbonés

Buti‐Soler

et al. 2018

Acad Dermatol Venereol

118

100

View full text Add to dashboard Cite

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“…Of note, it has been shown in many studies that PASI is not correlated with metabolic syndrome. [20][21][22][23] New data has recently emerged showing MK has an important function in the steps of inflammation which also functions in the pathogenesis of both psoriasis and metabolic syndrome. 24,25 It is thought that MK might function in inflammation pathways via recruiting inflammatory cells including neutrophils and macrophages by inducing monocyte chemoattractant protein-1 (MCP-1).…”

Section: Discussionmentioning

confidence: 99%

Serum Midkine Levels in Patients with Psoriasis

Purnak¹,

Çakmak²,

Çakır³

et al. 2020

Turkiye Klinikleri J Dermatol

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Midkine (MK) is a multifunctional molecule functioning in the developmental period of the fetus. It was first discovered in embryonic carcinoma cells with increased expression in early stages of differentiation. 1 In adults, MK is expressed in limited sites such as epidermis, kidney, lymphocytes and gut. 2 MK has critical function in development and repair mech-anisms in normal cells as well as tumor growth, invasion and angiogenesis in cancer cells. 3,4 Various studies have shown that tumor prognosis is worse in the patients with higher MK levels. 5-7 Moreover, higher serum MK levels were detected in various inflammatory diseases such as rheumatoid arthritis, inflammatory bowel diseases, atherosclerosis and Turkiye Klinikleri J Dermatol. 2020;30(1):1-5 ABS TRACT Objectives: Midkine is a heparin-binding growth factor which functions in development and repair mechanisms. It also has roles in tumor growth, invasion and angiogenesis in cancer cells. Recently, higher serum midkine levels were detected in inflammatory diseases such as rheumatoid arthritis, inflammatory bowel diseases, atherosclerosis and obesity. In the present study, we aimed to investigate serum midkine levels in patients with psoriasis. We also tried to reveal if there is a relationship between serum midkine levels and psoriasis disease activity. Material and Methods: Forty-five patients with psoriasis and age, sex-matched healthy controls were enrolled in the study. Serum midkine level, complete blood count, fasting serum glucose level, lipid profile (HDL, LDL, triglyceride, cholesterol), CRP (C-reactive protein), serum liver function tests (ALT; AST) and kidney function tests (urea and creatinine) were studied. Psoriasis area severity index (PASI) scores and body mass indexes were calculated for each patient. Results: We found significantly higher serum midkine levels in patients with psoriasis compared to control group. There was no correlation between serum midkine levels and PASI scores. Serum midkine levels were correlated with serum triglyceride levels in patients with psoriasis. Conclusion: This study showed that serum midkine levels were significantly higher in psoriatic patients than controls. As midkine is only correlated with serum triglyceride level and not correlated with PASI, we think serum midkine is not an ideal serum marker for the evaluation of psoriasis activity.ÖZET Amaç: Midkin, büyüme, gelişme ve tamir mekanizmalarında görevli bir büyüme faktörüdür. Ayrıca, kanser hücrelerinde tümör büyümesi, invazyon ve anjiyogenezden sorumludur. Son zamanlarda, romatoid artrit, inflamatuar bağırsak hastalıkları, ateroskleroz ve obezite gibi bircok inflamatuvar hastalıkta yüksek serum midkin seviyeleri tespit edilmiştir. Çalışmamızda, psöriyazisli hastalarda serum midkin seviyesini ve bu seviyelerin hastalık aktivitesi ile ilişkisini belirlemeyi hedefledik. Gereç ve Yöntemler: Psöriyazis tanısı almış 45 hasta ile yaş ve cinsiyet açısından eşleşmiş kontroller çalışmaya dahil edildi. Tüm hasta ve kontrollerde, serum midkin seviyeleri, tam kan...

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“…The Czech study also refers to other European registries showing a prevalence of DMII in psoriasis patients of 9.9-12%. Similarly, 2017 and 2018 studies found the prevalence of DMII in psoriasis patients to be 10% 13 and 12%, 14 respectively. Another 2015 paper by Schaarschmidt et al reported the prevalence of DMII to be 14.5% 9 while a review from the Malaysian Psoriasis Registry, spanning 2007-2016, and a study of over 2,700 patients in the Bringham psoriasis and psoriatic arthritis registries both found the prevalence of DMII in their cohorts to be at or near 17%.…”

Section: Type 2 Diabetes Mellitusmentioning

confidence: 90%

Review of the Prevalence of Cardiovascular and Metabolic Comorbidities of Psoriasis

Vebman¹,

Choy²,

Yao³

2020

J of Skin

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Introduction:-Psoriasis is a common disease that is linked with several other diseases. Our goals were to analyze and present literature on prevalence of various psoriatic comorbidities, and provide an estimate of what percent of psoriasis patients might have or develop Myocardial/cardiovascular/heart disease, stroke, diabetes, obesity, hypertension, or metabolic syndrome.Method:-To collect the results, we searched PubMed to identify papers that studied the frequency of the most common comorbidities of psoriasis. We used about 20. The search terms used were the particular comorbidity (or synonyms) and psoriasis. Papers were selected where the prevalence data were listed by percentages of the studied population. Prevalence data from each paper were collected and charted, and then compared. We did not use data that concerned Psoriatic Arthritis. We also recorded outliers, where frequencies did not fit with the other data found.Results:-Results for prevalence of myocardial/cardiovascular/heart disease were mixed, varying by age and severity of disease. There are few papers on prevalence of stroke, but our review suggests risk of stroke increases with severity of psoriasis. The prevalence of diabetes was largely between 10% and 20%. Obesity’s prevalence was mostly between 15% and 30%, while hypertension hovered around 30%, and metabolic syndrome prevalence was mostly between 27% and 50%.Conclusions:-There are many comorbidities of psoriasis. The complex interaction between cutaneous inflammation and heart disease, stroke, diabetes, hypertension and metabolic syndrome raises many questions about cause and effect or simple association.

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Factors influencing cardiometabolic risk profile in patients with psoriasis

Abstract: Psoriasis severity was associated with diabetes, insulin-resistance, smoking habit and higher cardiovascular risk. Metabolic syndrome was related to age and menopause but not to psoriasis severity.

Cited by 17 publications

References 21 publications

Psoriasis, metabolic syndrome and cardiovascular risk factors. A population‐based study

Psoriasis, metabolic syndrome and cardiovascular risk factors. A population‐based study

Serum Midkine Levels in Patients with Psoriasis

Review of the Prevalence of Cardiovascular and Metabolic Comorbidities of Psoriasis

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