In the new situation of building an entrepreneurial ecosystem, faced with the global multi-agent competition of the system, how new ventures should integrate with the system, isomorphism, and use their own advantages to cultivate new venture resilience has become an important global issue. The purpose of this study is to explore the combined impact of digital transformation, entrepreneurial ecological orientation, and organizational structure on the resilience of new ventures. Based on qualitative comparative analysis (QCA), this study systematically explores the significant key conditions and configuration effects that affect the cultivation of new venture resilience. There are four types of configurations that help new ventures to cultivate resilience, namely: strategic change, flexible response, leadership niche and institutional logic. This study explores how these three dimensions interact to achieve high firm resilience, ultimately contributing to the research of resilience from the perspective of the entrepreneurial ecosystem.