Factors influencing halothane hepatotoxicity in the rat hypoxic model

Jee, R.; Sipes, I. G.; Gandolfi, A. Jay; Brown, B. R.

doi:10.1016/0041-008x(80)90114-3

Cited by 63 publications

(6 citation statements)

References 33 publications

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“…The hypoxic rat model of halothane-induced hepatotoxicity has been shown to consistently produce significant liver damage (12,20,23,26). The hypoxic conditions and induction of drug-metabolizing enzyme with phenobarbital in this model are essential to achieve liver damage.…”

Section: Discussionmentioning

confidence: 99%

“…A blind morphological evaluation of specimens was performed at a magnification of 200ϫ (12) by two independent pathologists, one from Allegheny College of Pennsylvania and one from Cooper Hospital/University Medical Center. The fields were scored according to criteria described by Jee et al (12) and classified as follows: 0 ϭ normal, 1 ϭ mild cellular disruption in less than 25% of field area, 2 ϭ moderate cellular disruption and appearance of balloon cells and vacuolation in greater than 50% field area, 3 ϭ extensive cell disruption and vacuolation in greater than 50% field area, 4 ϭ extensive cell disruption with occasional centrilobular necrosis, and 5 ϭ extensive cell disruption with multiple centrilobular necrosis in more than 50% field area. The average histopathologic score from two pathologist for each liver preparation was used as a final score.…”

Section: Histopathologic Evaluationmentioning

confidence: 99%

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The effects of chronic exercise on anesthesia induced hepatotoxicity

Daggan

Zafeiridis²,

Δίπλα³

et al. 2000

Medicine and Science in Sports and Exercise

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Section: Discussionmentioning

confidence: 99%

Section: Histopathologic Evaluationmentioning

confidence: 99%

The effects of chronic exercise on anesthesia induced hepatotoxicity

Daggan

Zafeiridis²,

Δίπλα³

et al. 2000

Medicine and Science in Sports and Exercise

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“…Specimens from each group were examined blindly by pathologist who was unaware of the treatment regimens. Histopathological changes on tissue sections were scored according to Jee et al 23 These changes were graded as follows: (0) normal, (1) mild cellular disruption in less than 25% of area, (2) moderate cellular disruption and appearance of balloon cells and vacuolation in greater than 50% area, (3) extensive cellular disruption and vacuolation in greater than 50% area, (4) extensive cellular disruption with occasional centrilobular necrosis, (5) extensive cellular disruption with multiple centrilobular necrosis in more than 50% area.…”

Section: Histological Evaluationmentioning

confidence: 99%

Erdosteine modulates radiocontrast‐induced hepatotoxicity in rat

Yeşildağ

Özden

Yilmaz

et al. 2009

Cell Biochemistry & Function

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It has been suggested that reactive oxygen species (ROS) plays an important role in radio contrast media (RCM)-induced ischemia reperfusion tissue injury although antioxidants may have protective effects on the injury. We investigated the effects of erdosteine as an antioxidant agent on RCM-induced liver toxicity in rats by evaluation of lipid peroxidation (as TBARS), catalase (CAT), superoxide dismutase (SOD), reduced glutathione (GSH) and glutathione peroxidase (GSH-Px) values and histological evaluation. Twenty-one rats were equally divided into three groups as follows: control, RCM, and RCM plus erdosteine. RCM was intraperitoneally administered for 1 day. Erdosteine was administered orally for 2 days after RCM administration. Liver samples were taken from the rats and they homogenized in a motor-driven tissue homogenizer. TBARS levels were significantly (p < 0.005) higher in RCM group than in control although SOD activities significantly (p < 0.05) decreased in RCM group. TBARS levels were lower in RCM plus erdosteine group than in control although SOD activity and GSH level increased (p < 0.05) in liver as compared to RCM alone. Erdosteine showed also histopathological protection (p < 0.0001) against RCM induced hepatotoxicity. GSH-Px and CAT activities were not statistically changed by the erdosteine. According to our results, it can be concluded that radiocontrast media can induce oxidative stress in liver as suggested by previous studies. Erdosteine seems to be protective agent on the radiocontrast media-induced liver toxicity by inhibiting the production of ROS via the enzymatic antioxidant system.

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“…However, its associated high mortality engenders concern among clinicians (1). Experimental evidence has demonstrated that reductive halothane metabolism can result in liver injury in animals (2,3 ) . The proposed mechanism of injury is formation of reactive intermediate metabolites whose binding to tissue macromolecules ultimately results in cellular dysfunction and death.…”

mentioning

confidence: 99%

Does Evidence of Reductive Halothane Biotransformation Correlate Halothane with Hepatic Binding of Metabolites in Obese Patients?

Bentley¹,

Vaughan²,

Cork³

et al. 1981

Anesthesia & Analgesia

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Does evidence of reductive halothane biotransformation correlate with hepatic binding of metabolites in obese patients? Anesth Analg 1981 ;60:548-51.Covalent binding of fluorinated anesthetic metabolites was measured using intraoperative liver biopsies obtained from 48 morbidly obese patients randomly assigned to receive N,O-O, combined with either fentanyl, enflurane, or halothane. No difference in binding was found between anesthetic groups. In addition, preoperative and postoperative levels of serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) did not differ among three groups of patients. However, hepatic organic fluoride binding significantly correlated with peak serum ionic fluoride in patients given halothane ( p c 0.001, r = 0.68). Thus, the fluorinated metabolites binding assay is a reliable index of reductive halothane metabolism. Possible application of this assay to aid in the diagnosis of postoperative liver dysfunction is suggested.

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Factors influencing halothane hepatotoxicity in the rat hypoxic model

Cited by 63 publications

References 33 publications

The effects of chronic exercise on anesthesia induced hepatotoxicity

The effects of chronic exercise on anesthesia induced hepatotoxicity

Erdosteine modulates radiocontrast‐induced hepatotoxicity in rat

Does Evidence of Reductive Halothane Biotransformation Correlate Halothane with Hepatic Binding of Metabolites in Obese Patients?

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