Factors Influencing Escherichia coli and Enterococcus durans Growth in Parenteral Nutrition With and Without Lipid Emulsion to Inform Maximum Duration of Infusion Policy Decisions

Abstract

The presence of lipid and an increasing proportion of energy from lipid in PN favored the growth of E coli and E durans. Osmolarity changes and the nutrient type causing these changes independently affect the growth of these microbes. Each effect needs to be considered when establishing guidelines based on the growth of potential contaminants in different types of PN.

Effects of lipid emulsions on the formation of Escherichia coli–Candida albicans mixed-species biofilms on PVC

“…CVCs are widely used in clinics to administer parenteral nutrition (PN) due to the high risk of phlebitis 1,2 . However, the risk of catheter-related bloodstream infections (CRBSIs) for patients receiving a long period of PN through CVCs is relatively high due to the presence of lipid emulsions, an indispensable component of PN, which provide vital energy and fatty acids for patients and favour the growth of various microbes, including bacteria and fungi 3,4 .However, more than 15% of CRBSIs occurring during PN treatment are polymicrobial rather than single infections caused by one microorganism 5 . It is noteworthy that Candida albicans (C. albicans) is one of the leading pathogens causing CRBSIs associated with high morbidity and mortality.…”

“…CVCs are widely used in clinics to administer parenteral nutrition (PN) due to the high risk of phlebitis 1,2 . However, the risk of catheter-related bloodstream infections (CRBSIs) for patients receiving a long period of PN through CVCs is relatively high due to the presence of lipid emulsions, an indispensable component of PN, which provide vital energy and fatty acids for patients and favour the growth of various microbes, including bacteria and fungi 3,4 .…”