Factors influencing innate immunity and vaccine responses in infancy

Kampmann, Beate; Jones, Christine E

doi:10.1098/rstb.2014.0148

Cited by 28 publications

(26 citation statements)

References 39 publications

(45 reference statements)

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“…Cytomegalovirus infection is acquired early in life by most infants in Africa and has a profound effect on the immune system ( 101 – 103 ). Other factors could include nutrition, genetics, and season of birth ( 104 , 105 ).…”

Section: Factors That Affect Bcg-induced Immune Responsesmentioning

confidence: 99%

What Have We Learnt about BCG Vaccination in the Last 20 Years?

2017

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A number of new tuberculosis (TB) vaccines have been or are entering clinical trials, which include genetically modified mycobacteria, mycobacterial antigens delivered by viral vectors, or mycobacterial antigens in adjuvant. Some of these vaccines aim to replace the existing BCG vaccine but others will be given as a boosting vaccine following BCG vaccination given soon after birth. It is clear that the existing BCG vaccines provide incomplete and variable protection against pulmonary TB. This review will discuss what we have learnt over the last 20 years about how the BCG vaccine induces specific and non-specific immunity, what factors influence the immune responses induced by BCG, and progress toward identifying correlates of immunity against TB from BCG vaccination studies. There is still a lot to learn about the BCG vaccine and the insights gained can help the development of more protective vaccines.

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Section: Factors That Affect Bcg-induced Immune Responsesmentioning

confidence: 99%

What Have We Learnt about BCG Vaccination in the Last 20 Years?

2017

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“…This role of CTH as antigen extracted from A. mellifera to increase antibodies production in young goats could be linked to the factors innate immunity and vaccine responses in neonates as described by Kampmann and Jones (2015) which were affected by the type of vaccine, timing of vaccination, location, microbiome, co-infections, maternal factors, host genetics and pattern recognition receptors. More over an effort to increase the goat's immunity by antigen combined with adjuvant has been performed by Iqbal et al (2016) in young goats: They result showed a positive response to reject the parasite insect in the animal tested by using this combination substances.…”

Section: Resultsmentioning

confidence: 99%

Insect Crude Thoraxial Antigen-G Extracted from Apis mellifera to Enhance Serum Immunoglobulin of Goats: An Entomology Contribution in Animal Science

Toar¹,

Rumokoy

Untu³

et al. 2019

anprod

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This research was conducted to evaluate the influence of insect crude thoraxial antigen-G (CTA) extracted from Apis mellifera L. (Hymenoptera: Apidae) to enhance goat’s serum immunoglobulin level. The first part of this study was the determination of insect CTA proportion level. The insects were collected from four different places: Tomohon, Minahasa, North-Minahasa and Manado areas. The second part of the study was the application of A. mellifera CTA substance on serum immunoglobulin level classification. In this part, twelve young goats handled with traditional maintenance. The animals experiment were divided in two groups: control group and the other treated with 100 µg CTA extract. The proportion of serum immunoglobulins level of goats was detected at 14th days after immunization with insects CTA extract, and compared with the animals immunoglobulin levels at the starting day of treatment. The data of CTA extract proportion level of the insects collected were subjected to statistically analysis using the general linear model (GLM) procedure of SPSS 22. Concerning the classification level of the animal treated with CTA was statistically analyzed according to Mann-Whitney test. The results showed that the proportion level of thoraxial antigens-G of A. mellifera from all areas observed were not significant different (P>0.05). This crude thoraxial antigens-G of this insect were able to increase serum antibody level of the experiment animal after 14 days of immunization. The immunoglobulin level qualification of animals in treated group were significant higher (P<0.05) than in control group. We concluded that the CTA extract of the Apis mellifera could be empowered to improve the young goat immunity against the pathogenic microbes in their environment.

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“…The nonspeci c effects of vaccines have long been dismissed or minimized, but these biological phenomena should not be ignored, particularly considering that the innate immune system reveals some adaptive characteristics. Thus, it is now urgent that the effects of vaccination should be viewed in a much more systematic and open-minded manner [2,3]. Worryingly, a transitory state of immunosuppression subsequently to vaccination has been described in several studies [4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…Sentinel cells of the innate immune system, such as macrophages and neutrophils, represent the rst line of defense against a drastic exposure to infectious pathogens in neonates. The innate immune system in turn stimulates the adaptive immune response, and as a result the stimulation of immune memory responses [3,14,15]. Thus, another factor that should be investigated is the optimal age for vaccination [11,[16][17][18][19] because age has an impact on an animal's immune response [20,21].…”

Section: Introductionmentioning

confidence: 99%

“…Thus, another factor that should be investigated is the optimal age for vaccination [11,[16][17][18][19] because age has an impact on an animal's immune response [20,21]. While colonization of the neonate with distinct microorganisms is in uenced by the immediate environment, the use of vaccines to assess the immune pathways provides an opportunity to study speci c types of antigens exposure and examine their downstream effects [3].…”

Section: Introductionmentioning

confidence: 99%

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Implications of Intranasal Polyvalent Vaccination for Pulmonary Alveolar Macrophage and Neutrophil Functions in Calves

Gomes

Batista

Souza

et al. 2020

Preprint

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Background: Vaccines undoubtedly represent a promising and much needed approach to combatting infectious diseases, but there is also increasing evidence that they exert nonspecific effects, and these effects may be beneficial but also sometimes detrimental. Thus, here we sought to explore the effect of intranasal vaccination on the functions of pulmonary alveolar macrophages and neutrophils in calves of different ages.Results: Respiratory clinical signs and impaired microbicidal and phagocytic activities were observed for the alveolar neutrophils and vacuolized macrophages in the vaccinated calves compared with those in the unvaccinated calves, particularly at 15 days of age.Conclusions: Our results indicated that the use of some polyvalent attenuated and modified live virus vaccines in early stage of calves’ life, especially those under 15 days of age, should be restricted to farms in which the cattle are at a higher risk of contracting these viral infections, particularly considering the importance of alveolar macrophages and neutrophils against bacterial pathogens in a period of intense pulmonary challenge.

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Factors influencing innate immunity and vaccine responses in infancy

Cited by 28 publications

References 39 publications

What Have We Learnt about BCG Vaccination in the Last 20 Years?

What Have We Learnt about BCG Vaccination in the Last 20 Years?

Insect Crude Thoraxial Antigen-G Extracted from Apis mellifera to Enhance Serum Immunoglobulin of Goats: An Entomology Contribution in Animal Science

Implications of Intranasal Polyvalent Vaccination for Pulmonary Alveolar Macrophage and Neutrophil Functions in Calves

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