Factors influencing lithium versus valproate prescription preference in the maintenance treatment of bipolar patients: a report from the Italian Early Career Psychiatrists (SOPSI-GG)

Buoli, Massimiliano; Gattoni, E.; Collantoni, Enrico; Monteleone, Alessio Maria; Solmi, Marco; Longo, Luisa; Ribolsi, Michele; Santambrogio, Jacopo; Bersani, Francesco Saverio; Aguglia, Andrea; Serafini, Gianluca; Signorelli, Maria Salvina; Dell’Osso, Bernardo; Luciano, Mario; Galderisi, Silvana

doi:10.1080/13651501.2020.1865405

Cited by 7 publications

(7 citation statements)

References 41 publications

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“…These differences could be due to a different mean age of prescribers and clinical experience between the different centers. A recent Italian study demonstrated the preferential prescription of Li versus valproate for the maintenance treatment of BD among Italian early career psychiatrists 28 . Prescription rates for Li continue to remain relatively low in North America despite a significant evidence base favoring Li's superior efficacy and capacity to protect against neuroprogression, suicide, and all‐cause mortality 29–38 .…”

Section: Discussionmentioning

confidence: 99%

“…Italian study demonstrated the preferential prescription of Li versus valproate for the maintenance treatment of BD among Italian early career psychiatrists. 28 Prescription rates for Li continue to remain relatively low in North America despite a significant evidence base favoring Li's superior efficacy and capacity to protect against neuroprogression, suicide, and all-cause mortality. [29][30][31][32][33][34][35][36][37][38] Low prescription rates for Li in the North American sites is consistent with prior literature.…”

Section: These Differences Could Be Due To a Different Mean Age Of Pr...mentioning

confidence: 99%

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Patterns of pharmacotherapy for bipolar disorder: A GBC survey

et al. 2023

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ObjectivesTo understand treatment practices for bipolar disorders (BD), this study leveraged the Global Bipolar Cohort collaborative network to investigate pharmacotherapeutic treatment patterns in multiple cohorts of well‐characterized individuals with BD in North America, Europe, and Australia.MethodsData on pharmacotherapy, demographics, diagnostic subtypes, and comorbidities were provided from each participating cohort. Individual site and regional pooled proportional meta‐analyses with generalized linear mixed methods were conducted to identify prescription patterns.ResultsThis study included 10,351 individuals from North America (n = 3985), Europe (n = 3822), and Australia (n = 2544). Overall, participants were predominantly female (60%) with BD‐I (60%; vs. BD‐II = 33%). Cross‐sectionally, mood‐stabilizing anticonvulsants (44%), second‐generation antipsychotics (42%), and antidepressants (38%) were the most prescribed medications. Lithium was prescribed in 29% of patients, primarily in the Australian (31%) and European (36%) cohorts. First‐generation antipsychotics were prescribed in 24% of the European versus 1% in the North American cohort. Antidepressant prescription rates were higher in BD‐II (47%) compared to BD‐I (35%). Major limitations were significant differences among cohorts based on inclusion/exclusion criteria, data source, and time/year of enrollment into cohort.ConclusionsMood‐stabilizing anticonvulsants, second‐generation antipsychotics, and antidepressants were the most prescribed medications suggesting prescription patterns that are not necessarily guideline concordant. Significant differences exist in the prescription practices across different geographic regions, especially the underutilization of lithium in the North American cohorts and the higher utilization of first‐generation antipsychotics in the European cohorts. There is a need to conduct future longitudinal studies to further explore these differences and their impact on outcomes, and to inform and implement evidence‐based guidelines to help improve treatment practices in BD.

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Section: Discussionmentioning

confidence: 99%

Section: These Differences Could Be Due To a Different Mean Age Of Pr...mentioning

confidence: 99%

Patterns of pharmacotherapy for bipolar disorder: A GBC survey

et al. 2023

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“…A cross-sectional survey on trainees in psychiatry and ECPs in different Italian regions was developed. The online survey was carried out during the month of December 2021, using the same methodology provided for other previous studies published by the ECP network of the Italian Society of Psychopathology (SOPSI-GG) [ 26 , 27 ]. The online survey was disclosed between January and March 2022.…”

Section: Methodsmentioning

confidence: 99%

Suicide-Related Knowledge among Italian Early Career Psychiatrists and Trainees: Results from a Cross-Sectional Survey

et al. 2022

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The training of mental health professionals is an important component of suicide-prevention programs. A cross-sectional survey was conducted in different Italian regions to evaluate knowledge of, and attitudes toward, suicide as well as the experience of a patient’s suicide or a suicide attempt in early career psychiatrists (ECPs) and trainees (N = 338). The Suicide Knowledge and Skills Questionnaire and the Impact of a Patient’s Suicide on Professional and Personal Lives scale were administered. Furthermore, symptoms of intrusion, avoidance, and arousal were examined through the Impact of Event Scale in ECPs and trainees who had experienced the suicide of a patient or a suicide attempt. Participants with training were more confident in the clinical management of suicide-risk patients. The group with experience of a patient’s suicide reported more suicide skills except for support and supervision. Finally, the participants who reported a patient’s suicide presented a more conservative patient selection, difficulties in relationships, loss of self-esteem, dreams linked to suicide, intrusive thoughts of suicide, guilt, and anger. Our results show that knowledge of, and attitudes toward, suicide are essential in the management of suicide-risk patients.

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“…Основою лікування при БР є фармакотерапія, яку застосовують з двома наступними цілями: лікування при гострих епізодах без підвищення ризику появи симптомів протилежної полярності; попередження рецидивів для уникнення хронічного перебігу [4]. Підходи до лікування орієнтують на три основні клінічні ситуації: маніакальна, депресивна та підтримувальна фази.…”

Section: ключові терапевтичні рекомендаціїunclassified

“…У 2 систематичних оглядах 10 (n=1427) та 25 (n=3252) рандомізованих клінічних досліджень повідомлялося про порівнянну ефективність вальпроату і літію [9,10]. Проте використання останнього ускладнюється його вузьким терапевтичним індексом та необхідністю контролювати концентрацію в крові [4]. Останніми роками зростає інтерес до персоналізації використання СН, у тому числі в поєднанні з антипсихотичними препаратами (ААП) (атиповими чи 2-го покоління) у моно-чи комбінованій терапії залежно від стадії перебігу захворювання та клінічних ознак [11].…”

Section: «пшеничне поле з воронами» (вв гог; 1890 р)unclassified

На Крок Попереду Хвороби: Як Покращити Результати Терапії При Біполярному Розладі?

2023

UMJ

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Factors influencing lithium versus valproate prescription preference in the maintenance treatment of bipolar patients: a report from the Italian Early Career Psychiatrists (SOPSI-GG)

Cited by 7 publications

References 41 publications

Patterns of pharmacotherapy for bipolar disorder: A GBC survey

Patterns of pharmacotherapy for bipolar disorder: A GBC survey

Suicide-Related Knowledge among Italian Early Career Psychiatrists and Trainees: Results from a Cross-Sectional Survey

На Крок Попереду Хвороби: Як Покращити Результати Терапії При Біполярному Розладі?

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