“…Implants with surface treatments capable of improving bone-implant interactions, protein adsorption, adhesion, differentiation, and cell proliferation have been used in cases with impaired bone beds (Boyan et al, 2017;Khandelwal et al, 2013;Nack et al, 2015). Implants with hydrophilic surfaces have shown promising results in clinical studies with patients using anticoagulants (Marković et al, 2017), diabetic patients (Khandelwal et al, 2013), patients with a history of radiotherapy in the head and neck region (Nack et al, 2015), patients requiring bone grafting (Donos et al, 2018(Donos et al, , 2019Marković et al, 2016;Nedir et al, 2013;Yu et al, 2017;Zumstein et al, 2019), and patients undergoing rehabilitation of the posterior maxillary (Novellino et al, 2017) and mandibular regions (Velloso et al, 2019). To date, clinical studies involving SLActive hydrophilic surfaces in mandibular implant overdenture treatment (Al-Nawas et al, 2012;Müller et al, 2015;Quirynen et al, 2015;Reis et al, 2019;Stoker & Wismeijer, 2011) have observed 1-year survival rates of 97.8% (Al-Nawas et al, 2012) to 100% (Reis et al, 2019), 98% (Stoker & Wismeijer, 2011) after 40 months, and 97.8% to 98.9% after 5 years (Müller et al, 2015).…”