Factors influencing metabolism and toxicity of metals: a consensus report

doi:10.1289/ehp.78253

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Cited by 86 publications

References 109 publications

(142 reference statements)

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Cadmium and its compounds [MAK Value Documentation, 1993]

2012

The MAK‐Collection for Occupational Health and Safety

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Published in the series Occupational Toxicants , Vol. 5 (1993) The article contains sections titled: Toxic Effects and Modes of Action Effects in man Effects on animals Carcinogenicity Effects in Man Effects on Animals Genotoxicity Bioavailability studies Manifesto (MAK value/classification)

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Cadmium and its compounds [MAK Value Documentation, 1993]

2012

The MAK‐Collection for Occupational Health and Safety

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Lead effect on blood pressure in moderately lead‐exposed male workers

Telišman

Pizent

Jurasović

et al. 2004

American J Industrial Med

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Review: Reactive selenium metabolites as targets of toxic metals/metalloids in mammals: a molecular toxicological perspective

Gailer

2002

Applied Organom Chemis

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Human activities have been contaminating the environment with toxic heavy metal and metalloid compounds. Since the toxicity of one metal or metalloid can be dramatically modulated by the simultaneous ingestion of another, studies addressing the molecular basis of chemical interactions between toxic and essential elements are increasingly important. The intravenous injection of rabbits with selenite and arsenite or with selenite and mercuric mercury resulted in the in vivo formation of the seleno-bis (S-glutathionyl) arsinium ion, [(GS) 2 AsSe] À , or a glutathione-coated mercuric selenide, (GS) 5 (HgSe) core , in blood. The formation of these species (and the formation of a cadmium±selenium species in blood after the exposure of rats to selenite and cadmium) critically involves reactive selenite metabolites, such as GS±Se À and/or HSe À , which indicates that these physiologically important metabolites are molecular targets of ingested toxic metals and metalloids. The fate and stability of [(GS) 2 AsSe] À and (GS) 5 (HgSe) core in vivo imply that the chronic exposure of mammals to inorganic arsenic and mercury will cumulatively affect the bioavailability of selenium, which could lead to selenium deficiency. Since selenium deficiency is significantly associated with the etiology of cancer in humans, the GSH-driven in vivo formation of selenium-containing metal and metalloid species provides a likely molecular mechanism for the chronic toxicity of environmentally persistent inorganic arsenic, mercury and cadmium.

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Factors influencing metabolism and toxicity of metals: a consensus report

Cited by 86 publications

References 109 publications

Cadmium and its compounds [MAK Value Documentation, 1993]

Cadmium and its compounds [MAK Value Documentation, 1993]

Lead effect on blood pressure in moderately lead‐exposed male workers

Review: Reactive selenium metabolites as targets of toxic metals/metalloids in mammals: a molecular toxicological perspective

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