Factors influencing neonatal morbidity in gestational diabetic pregnancy

Nordlander, E; Hanson, Ulf; Persson, Bengt

doi:10.1111/j.1471-0528.1989.tb03281.x

Cited by 23 publications

(4 citation statements)

References 25 publications

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“…It may be that blood glucose level is a marker of a metabolic state associated with higher risk, rather than the direct cause of complications. Similar results have been observed by some authors who have found that after adjusting for maternal age, parity, and maternal body weight there was no correlation between blood glucose level and neonatal birth weight [3,15,16] . A Naylor et al study reported that cesarean sections were more common in patients diagnosed as having GDM and it was seen in those with no macrosomia [17] .…”

Section: Discussionsupporting

confidence: 90%

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Gestational Diabetes in a High-Risk Population: Perinatal Outcomes with Impaired Fasting Plasma Glucose

Zamzami¹

2007

med

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The aim of the study was to compare the perinatal outcomes of gestational diabetic patients with normal fasting plasma glucose level < 5.3 mmol/L, versus impaired fasting plasma glucose level ≥ 5.3 mmol/L on 100g oral glucose tolerance results. All gestational diabetic patients enrolled in the study were diagnosed by standard 100g oral glucose blood samples. Based on oral glucose tolerance results, patients were divided into two groups according to the fasting plasma glucose; Group 1 normal fasting plasma glucose < 5.3 mmol/L, and Group 2 impaired fasting plasma glucose ≥ 5.3 mmol/L. During the study period, a total of 292 patients were identified as having gestational diabetes mellitus. One hundred eighty-two (62.3%) were with normal fasting plasma glucose < 5.3 mmol/L and 110 (37.7%) patients had impaired fasting plasma glucose ≥ 5.3 mmol/L. The percentage of total and primary cesarean delivery and the arithmetic means ± SD of all fasting and postprandial plasma glucose measurements were significantly lower in-Group 1 compared with Group 2 patients. Patients with impaired fasting plasma glucose needed more insulin therapy and were associated with a higher rate of cesarean delivery compared to patients with normal fasting plasma glucose who may need ordinary follow-up rather than frequent surveillance.

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Section: Discussionsupporting

confidence: 90%

“…Perinatal mortality among the infants of mothers with gestational diabetes mellitus has been reduced to the rate that is not totally different than that of the general non-diabetic population [1][2][3] . Improved perinatal care has prevented such increase in perinatal mortality.…”

Section: Introductionmentioning

confidence: 96%

Gestational Diabetes in a High-Risk Population: Perinatal Outcomes with Impaired Fasting Plasma Glucose

Zamzami¹

2007

med

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“…4 Infact, a high prevalence of gestational diabetes around 18% has been reported in India. 5 GDM has been recognized as a clinical entity for 50years. 6 Gestational Diabetes Mellitus (GDM) is defined as carbohydrate intolerance with recognition in or onset during pregnancy irrespective of the treatment with diet or insulin.…”

Section: Discussionmentioning

confidence: 99%

Rate of Preeclampsia Influenced by Severity of Gestational Diabetes

Neelima¹,

Bindu²

2018

IJCMR

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Introduction Gestational Diabetes Mellitus (GDM) is defined as any degree of glucose intolerance with onset or first recognition during pregnancy. GDM has well known adverse effects on pregnancy and its outcome, especially on the fetus. GDM has been found to be more prevalent in urban areas than in rural areas. Diabetic pregnancies complicated by preeclampsia are of concern because of poor maternal and perinatal outcome. The purpose of the study was if the rate of preeclampsia is influenced by severity of gestational Diabetes. Material and methods: 100 pregnant women who are diagnosed as having gestational diabetes, followed up till the delivery for the development of preeclampsia. All pregnant women with gestational diabetes who gave the informed consent and detailed history. Results: Incidence of preeclampsia in pregnant women with Gestational Diabetes is 30%. Rate of preeclampsia was increased with increasing the fasting blood sugar levels of OGTT. GDM Patients who developed preeclampsia had significant higher HbA1C levels (7.47) compared to GDM patients who did not (6.42). Mean birth weight of GDM with PE group is lower (2.94 +/-0.65) than that of GDM without PE group (3.26 +/-0.67). Significant difference in NICU admissions among two groups. Among GDM patients who developed preeclampsia, most of the cases (53.3%) GDM was diagnosed in third trimister. Conclusion: Early detection of Gestational diabetes with good antenatal care and strict glycemic control may decrease the incidence of preeclampsia. Regular and more frequent Blood Pressure monitoring is required in Gestational Diabetes pregnant women, so there by we can decrease the maternal morbidity and mortality.

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“…İlk kez gebelikte ortaya çıkan herhangi bir düzeydeki glukoz intoleransı olarak tanımlanan GDM, gebe sağlığı ve hasta gebeden dünyaya gelecek bebeklerin sağlığını olumsuz etkileyen bir problemdir. Annede hipertansif problemlere, doğum eylemi problemlerine, gebelik sonrasındaki hayatta yüksek Diabetes Mellitus gelişme riskine yol açan, hasta anne bebeğinde perinatal mortaliye ve morbiditeyi arttıran GDM'un, tüm gebeliklerin % 7-36'sı gibi önemli bir kısmını etkilediği bulunmuştur (5,6,7). Gestasyonel diyabet tarama ve tanısı ACOG (American Collage of Obstetrics and Gynecology ) ve ADA (American Diabetes Association)'nın tarama programına göre rutin olarak 24-28 haftalık gebelere önceden diyabet tanısı almamışsa 75 mg OGTT yapılıp açlık, 1. saat ve 2. saat glikoz ölçümü yapılır.…”

Section: Introductionunclassified

Evaluation of Metabolic Parameters of Gestational Diabetic Patients in Postpartum Period

Türker¹,

Çavuşoğlu²,

Ahbab³

et al. 2018

Haseki

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Amaç: Gestasyonel diabetes mellitus (GDM) postpartum dönemde tip 2 diabetes mellitus gelişimi ve metabolik disfonksiyon için yüksek risk faktörüdür. Bu sebeple biz gestasyonel diabetik hastaların postpartum dönemde metabolik parametrelerini değerlendirdik.Yöntemler: 2011-2014 yılları arasında, Haseki Eğitim ve Araştırma Hastanesi Kadın Hastalıkları ve Doğum Polikliniğinde 24. gebelik haftasında açlık ve tokluk plazma kan glukozu yüksek tespit edilerek OGTT uygulanıp, GDM tanısı konularak Endokrinoloji polikliniğine yönlendirilmiş olan 40 hasta 05.03.2014 tarih ve karar No:91 sayılı etik kurul onayı alınarak postpartum dönemde çalışmaya alındı. 6. aydan başlayarak kontrole çağırıldı ve boy, kilo, BKİ, ölçümsel parametreleri değerlendirildi. Çalışmada HbA1c açlık kan glukozu (AKG), tokluk kan glukozu (TKG), insülin, lipid profili, üre, kreatinin, spot idrarda protein/kreatinin parametrelerine bakıldı.Bulgular:Takip edilen periyodda 7 hastada postpartum diabetes mellitus gelişti. (%17,5) Postpartum diabetic hastalarda ortalama açlık kan glukoz düzeyi ve hbA1c değerleri anlamlı olarak yüksek bulundu (p=0,001, p=0,005) Ortalama BKI, bel çevresi, trigliserid düzeyeri iki grup arasında benzer bulundu. (p=0,521, p=0,607, p=0,240) Sonuç: Gestasyonel diabetik hastalarda gebelik sonrası diabetes mellitus gelişimi açısından kesin bir bulguya rastlanmadı. Ancak GDM, postpartum diyabetes mellitus gelişimi için risk faktörüdür.Anahtar Sözcükler: Diabetes mellitus, gestasyonel diabetes mellitus, metabolik parametreler Abs tractAim:Gestational diabetes mellitus (GDM) have high risk for type 2 diabetes mellitus and metabolic dysfunction after pregnancy. Therefore, we aimed to evaluate the metabolic parameters in participants with history of GDM Methods: It was enrolled 40 patients, who had high glucose level during fasting or/and after meal and abnormal glucose level during OGTT in 24-28 weeks, in endocrinology outpatient clinic between 2011-2014. We evaluated the metabolic parameters in the sixth month of postpartum period. Weight, height, BMI were evaluated. Blood tests were performed (fasting and after meal glucose level, insulin, lipid profile, hbA1c, urea, creatinine, spot urea protein/creatinine).Results: Postpartum diabetes mellitus was developed in 7 patients in follow up period (%17.5). Mean fasting glucose level and hbA1c values were statistically higher in postpartum diabetic patients (p=0.001, p=0.005, respectively). The mean BMI, waist circumference, triglyceride levels were similar between groups (p=0.521, p=0.607, p=0.240; respectively) Conclusion:There was not a precise finding to forsee permanent diabetes mellitus after pregnancy in GDM patients according to our study. Moreover, GDM enhances risk of postpartum ongoing diabetes mellitus.

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Factors influencing neonatal morbidity in gestational diabetic pregnancy

Cited by 23 publications

References 25 publications

Gestational Diabetes in a High-Risk Population: Perinatal Outcomes with Impaired Fasting Plasma Glucose

Gestational Diabetes in a High-Risk Population: Perinatal Outcomes with Impaired Fasting Plasma Glucose

Rate of Preeclampsia Influenced by Severity of Gestational Diabetes

Evaluation of Metabolic Parameters of Gestational Diabetic Patients in Postpartum Period

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