Factors influencing ovarian response to tamoxifen in anovulatory patients

Madani, Tahereh; Zafarani, Fatemeh; Eshrati, Babak

doi:10.1016/j.ijgo.2006.06.012

Cited by 1 publication

(1 citation statement)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The recognized features associated with resistance to anti-estrogen therapy include advanced age, increased body mass index (BMI), presence of PCOS, a high free androgen index, a high luteinizing hormone (LH) level, a raised LH: FSH ratio and a high mean ovarian volume. [ 15 16 ] The predictors of treatment response to letrozole are not known. This study was aimed at assessing the factors associated with resistance to letrozole at a dose of 2.5 mg among a group of women with WHO group II anovulation who underwent induction of ovulation with letrozole.…”

Section: Introductionmentioning

confidence: 99%

Factors associated with nonresponse to ovulation induction using letrozole among women with World Health Organization group II anovulation

Palihawadana

Wijesinghe

Seneviratne³

2015

J Hum Reprod Sci

View full text Add to dashboard Cite

CONTEXT:Letrozole, a third generation aromatase inhibitor is gaining importance in ovulation induction. Some prefer to use it as a second line agent in women who fail to respond to clomifene citrate. However, our knowledge about the predictors of response to letrozole is limited.AIMS:The study was aimed at identifying the factors associated with letrozole resistance among women with World Health Organization (WHO) group II anovulation.SUBJECTS AND METHODS:Study was conducted at the infertility clinic at a tertiary care hospital in Sri Lanka. A case–control study design was used and included 50 subjects with WHO group II anovulation (25 clomifene responsive and 25 clomifene resistant). After a treatment cycle of letrozole, the factors were compared between the subjects who responded and those who failed to respond to treatment.RESULTS:Ovulation was achieved in 76% (n = 19) of subjects who had responded to clomifene previously and in 24% (n = 6) with clomifene resistance. The factors associated with letrozole resistance included the presence of hirsutism (odds ratio [OR]: 3.89; 95% confidence interval [CI]: 1.2–12.3) and clomifene resistance (OR: 10.03; 95% CI: 2.81–35.7). The early follicular phase mean (standard deviation) luteinizing hormone level was significantly higher among the nonresponders (9.75 [4.78] – 7.28 [2.3]; P = 0.02). Nonresponders showed significantly lower levels of oestradiol on the 5th and 9th days (28.50 [3.39] pg/mL vs. 7.49 [3.62] pg/mL; P = 0.0007 and 142.04 [76.22] pg/mL vs. 28.10 [12.8] pg/mL; P = 0.0001) of the menstrual cycle, respectively.CONCLUSIONS:The features associated with resistance to Letrozole at a dose of 2.5 mg show some overlap with those associated with clomifene resistance. However, some features do not show similar association. The effectiveness of letrozole at a dose of 2.5 mg in induction of ovulation among women with clomifene resistance is low and it does not seem to be a suitable treatment at a dose of 2.5 mg for this indication.

show abstract

Section: Introductionmentioning

confidence: 99%