Factors Influencing Oxygen Concentration Gradients in the Intervertebral Disc

Stairmand, J. W.; Holm, Sture; Urban, J

doi:10.1097/00007632-199104000-00010

Cited by 107 publications

(81 citation statements)

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“…Vascular insufficiency as a result of atheromas should also be considered. [16][17][18][19][20] Analogous with our results, these presumptions may account for smoking as a cause of rLDH. In contrast with these findings, however, some studies found no relationship between smoking and rLDH.…”

Section: Discussionsupporting

confidence: 89%

Factors that influence recurrent lumbar disc herniation

Yaman

Kazanci²,

Yaman

et al. 2017

Hong Kong Med J

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Section: Discussionsupporting

confidence: 89%

Factors that influence recurrent lumbar disc herniation

Yaman

Kazanci²,

Yaman

et al. 2017

Hong Kong Med J

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“…This is one of the pathways by which nutrients normally reach the disc [24]. The nutritive status of the disc is thought to be precarious, requiring only a small reduction of efficiency to compromise it [22]. Hence, restriction of vascular flow or available surface area for exchange, such as could occur by narrowed channels, might in turn lead to a decrease in available nutrients for normal disc cell metabolism and thence to disc degeneration [22].…”

Section: Discussionmentioning

confidence: 99%

“…The nutritive status of the disc is thought to be precarious, requiring only a small reduction of efficiency to compromise it [22]. Hence, restriction of vascular flow or available surface area for exchange, such as could occur by narrowed channels, might in turn lead to a decrease in available nutrients for normal disc cell metabolism and thence to disc degeneration [22]. This is known to alter the loading within the spine [13], which may then potentiate a pathological cycle leading to greater vertebral sclerosis and further degeneration of the disc.…”

Section: Discussionmentioning

confidence: 99%

Does the thickness of the vertebral subchondral bone reflect the composition of the intervertebral disc?

et al. 1997

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Degeneration of the intervertebral disc, seen radiologically as loss of disc height, is often associated with apparent remodelling in the adjacent vertebral body. In contrast, maintenance or apparent increase in disc height is a common finding in osteoporosis, suggesting the properties of the intervertebral disc may be dependent on those of the vertebral body or vice versa. We have investigated this relationship by measuring the radiological thickness of the subchondral bone and comparing it to the chemical composition of the adjacent disc. Sagittal slabs were sampled from lumbar spines obtained at autopsy and X-rayed microfocally. The thickness of the subchondral bone was measured and correlated with the composition of the adjacent intervertebral disc. Eighty-three cadaveric endplates were studied from individuals aged 17-85 years. There was regional variation in thickness of the subchondral bone, being greater adjacent to the annulus than the nucleus, and the endplates cranial to the disc were thicker than those caudal. There was a positive correlation between the thickness of the subchondral bone and the proteoglycan content of the adjacent disc, particularly in the region of the nucleus. A weaker correlation was seen here between water content and thickness, whilst there was no significant correlation at the annulus or between the bone thickness and collagen content. The positive relationship between the radiographic thickness of vertebral subchondral bone and the proteoglycan content of the adjacent disc seen in human cadaveric material could be due to the bone responding to a greater hydrostatic pressure being exerted by discs with higher proteoglycan content than by those with less proteoglycan present. It is suggested that while this is true in "normal" specimens, the relationship becomes altered in disease states, possibly because of changes to the nutritional pathway of the disc, with resultant endplate-bone remodelling affecting the flow of solutes to and from the intervertebral disc.

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“…Mature disc nucleus cells appear to generate ATP virtually only by glycolysis. They thus use glucose and produce lactic acid at a high rate [13,110]. Although they do not require oxygen to remain alive, cellular activity and matrix synthesis is reduced significantly at low oxygen concentrations [42,47].…”

Section: Disc Nutritionmentioning

confidence: 99%

Tissue engineering and the intervertebral disc: the challenges

2008

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Disc degeneration is a common disorder. Although the back pain that can develop in association with this is rarely life-threatening, the annual cost in terms of morbidity, lost productivity, medical expenses and workers' compensation benefits is significant. Surgical intervention as practised currently is directed towards removing the damaged or altered tissue. Development of new treatment modalities is critical as there is a growing consensus that the strategies used currently for symptomatic degenerative disc disease may not be effective. Accordingly, there is a need to develop an entirely new way to treat this disorder; regenerative medicine and tissue engineering approaches appear particularly promising in this regard. This paper reviews some of the challenges that currently are limiting the clinical application of this approach to the treatment of disc degeneration.

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Factors Influencing Oxygen Concentration Gradients in the Intervertebral Disc

Cited by 107 publications

References 0 publications

Factors that influence recurrent lumbar disc herniation

Factors that influence recurrent lumbar disc herniation

Does the thickness of the vertebral subchondral bone reflect the composition of the intervertebral disc?

Tissue engineering and the intervertebral disc: the challenges

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