Factors Influencing Patients’ Intention to Perform Physical Activity During Hematopoietic Cell Transplantation

Kolke, Samantha; Kuhlenschmidt, Megan; Bauer, Erica; Anthony, Mary K.; Gittleman, Haley; Caimi, Paolo; Mazanec, Susan R.

doi:10.1188/19.onf.746-756

Cited by 2 publications

(5 citation statements)

References 20 publications

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“…We were unable to reach four authors [ 23 , 43 , 52 , 55 ]; four authors replied that data was no longer available [ 37 , 47 , 48 , 50 ]. Four authors provided additional information [ 19 , 36 , 38 , 41 ], three authors provided additional data [ 40 , 45 , 49 ], and three authors provided individual patient data [ 39 , 44 , 54 ].…”

Section: Resultsmentioning

confidence: 99%

The effect of hematopoietic stem cell transplantation on patient-reported subjective oral dryness: a systematic review focusing on prevalence, severity and distress

Bulthuis

Gennip

Bronkhorst

et al. 2023

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Objective The aim of the present systematic review is to assess the prevalence and severity of and distress caused by xerostomia over time in adult hematopoietic stem cell transplantation (HSCT) recipients. Methods PubMed, Embase, and the Cochrane Library were searched for papers published between January 2000 and May 2022. Clinical studies were included if patient-reported subjective oral dryness was reported in adult autologous or allogeneic HSCT recipients. Risk of bias was assessed according to a quality grading strategy published by the oral care study group of the MASCC/ISOO, resulting in a score between 0 (highest risk of bias) and 10 (lowest risk of bias). Separate analysis focused on autologous HSCT recipients, allogeneic HSCT recipients receiving a myeloablative conditioning (MAC), and those receiving a reduced intensity conditioning (RIC). Results Searches yielded 1792 unique records; 22 studies met the inclusion criteria. The quality scores ranged between 1 and 7, with a median score of 4. The prevalence, severity, and distress of xerostomia increased shortly after HSCT. Severity of xerostomia in allogeneic MAC recipients was higher compared to allogeneic RIC recipients 2–5 months post-HSCT (mean difference: 18 points on 0–100 scale, 95% CI: 9–27); after 1–2 years, there was no significant difference anymore. Conclusion The prevalence of xerostomia in HSCT recipients is high in comparison to the general population. The severity of complaints is raised during the first year post-HSCT. The intensity of the conditioning plays a key role in the short-term development of xerostomia, while factors affecting the recovery in the long term remain largely unknown.

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Section: Resultsmentioning

confidence: 99%

The effect of hematopoietic stem cell transplantation on patient-reported subjective oral dryness: a systematic review focusing on prevalence, severity and distress

Bulthuis

Gennip

Bronkhorst

et al. 2023

Support Care Cancer

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“…Participants with a low level of physical activity at 4 months after allo-HSCT had 4 times greater probability of experiencing poor general health 1 year after allo-HSCT. This indicates that it is important to support patients and encourage physical activity before, during, and after allo-HSCT, as previous research has also shown that high symptom distress may make patients reluctant to engage in activity 30 . Tiredness has an undesirable impact on patients’ ability to engage in physical activity, whereas conversely, physical activity can positively affect tiredness and physical weakness 27 .…”

Section: Discussionmentioning

confidence: 97%

“…In addition, there is growing evidence of the importance of physical activity after allo-HSCT, but activity needs to be individualized in accordance with the patient’s health and condition, including his/her motivation. Therefore, healthcare professionals in allo-HSCT have an important role in communicating the positive effects of exercise on symptoms to patients and assuring them that it is safe to exercise during and after treatment with support based on the person’s perception and ability 30,33 …”

Section: Discussionmentioning

confidence: 99%

“…This indicates that it is important to support patients and encourage physical activity before, during, and after allo-HSCT, as previous research has also shown that high symptom distress may make patients reluctant to engage in activity. 30 Tiredness has an undesirable impact on patients' ability to engage in physical activity, whereas conversely, physical activity can positively affect tiredness and physical weakness. 27 Low physical activity at 4 months also showed 3 times greater probability of being on full-time sick leave 1 year after allo-HSCT.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, healthcare professionals in allo-HSCT have an important role in communicating the positive effects of exercise on symptoms to patients and assuring them that it is safe to exercise during and after treatment with support based on the person's perception and ability. 30,33 Distress relating to sexuality was found to be an issue from baseline and remained a cause of distress throughout the first year after allo-HSCT, with 3 of the 5 highest ranking distressing symptoms being related to sexual difficulties. Symptoms such as tiredness and poor physical condition may also have an adverse effect on sexuality together with factors such as the presence of GvHD, in particular of the genital tract, lack of potency (men), fear of relapse, and poor body image.…”

Section: Discussionmentioning

confidence: 99%

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Symptom Burden and Recovery in the First Year After Allogeneic Hematopoietic Stem Cell Transplantation

et al. 2022

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BackgroundPatients are affected by various symptoms after allogeneic hematopoietic stem cell transplantation (allo-HSCT) that can affect recovery. Research has mainly focused on symptom occurrence; thus, little is known about patients’ overall symptom burden.ObjectiveThe aim of this study was to examine patient-reported symptom burden in the first year after allo-HSCT and whether a high symptom burden 4 months after allo-HSCT predicts recovery, that is, general health and sick leave, 1 year after transplantation.MethodsAllo-HSCT patients aged 18 to 65 years were included (n = 189). Questionnaire data were collected on admission to the allo-HSCT unit, as well as 4 and 7 months and 1 year after allo-HSCT. Logistic regression evaluated relationships between demographic characteristics, chronic graft-versus-host disease, physical activity, and a high symptom burden.ResultsTiredness, susceptibility to infection, disinterest in sex, and physical weakness remained the most frequent symptoms, while distressing symptoms varied during the first year after allo-HSCT.Poor general health 1 year after allo-HSCT was associated with older age, low physical activity, and a high symptom burden 4 months after allo-HSCT. Full-time sick leave 1 year after allo-HSCT was associated with chronic graft-versus-host disease, low physical activity, and a high symptom burden 4 months after transplantation.ConclusionsExperiencing a high symptom burden 4 months after allo-HSCT can affect recovery 1 year after transplantation. Furthermore, low physical activity 4 months after allo-HSCT can predict both general health and sick leave 1 year after transplantation.Implications for PracticeRepeated symptom assessment, including experienced distress, is central for reducing overall symptom burden and supporting recovery after allo-HSCT.

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Factors Influencing Patients’ Intention to Perform Physical Activity During Hematopoietic Cell Transplantation

Cited by 2 publications

References 20 publications

The effect of hematopoietic stem cell transplantation on patient-reported subjective oral dryness: a systematic review focusing on prevalence, severity and distress

The effect of hematopoietic stem cell transplantation on patient-reported subjective oral dryness: a systematic review focusing on prevalence, severity and distress

Symptom Burden and Recovery in the First Year After Allogeneic Hematopoietic Stem Cell Transplantation

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