Factors Influencing Postexposure Immunprophylaxis of Hepatitis B Virus Infection With Hepatitis B Immune Globulin

Masuko, Kazuo; Mitsui, Takehiro; Iwano, Keiko; Yamazaki, Chikao; Aihara, Shinobu; Baba, Kiyoshi; Takai, Emiko; Tsuda, Fumio; Nakamura, Tetsuo; Miyakawa, Yuzo; Mayumi, Makoto

doi:10.1016/s0016-5085(85)80147-5

Cited by 23 publications

(9 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is now acceptable that HBeAg is a valuable marker of active HBV replication. However, some discrepancies exist between the detection of HBeAg and viral activity: differences in infectivity have been demonstrated among HBeAg-positive sera obtained from individual HBsAgpositive hemodialysis patients (21). Furthermore, large variations in the number of HBcAg-positive hepatocytes have been found among HBeAg-positive children (22).…”

Section: Discussionmentioning

confidence: 99%

Virological significance of HBeAg subtypes (HBeAg/1 and HBeAg/2) in patients with type B hepatitis

et al. 1987

View full text Add to dashboard Cite

In order to establish the virological significance of HBeAg subtypes (HBeAg/1 and HBeAg/2) during hepatitis B virus infection, HBsAg, HBeAg and hepatitis B virus DNA in serum and HBcAg in liver were determined quantitatively in relation to the detection of HBeAg subtypes in agar gel diffusion. Thirty-eight chronic HBsAg carriers with HBeAg, including 16 non-specific reactive hepatitis, 8 chronic persistent hepatitis, 11 chronic active hepatitis and 3 liver cirrhosis, who were seen at Tohoku University Hospital from 1983 to 1985, were examined. Significantly larger amounts of HBsAg, HBeAg and hepatitis B virus DNA in serum and HBcAg in liver were found in patients positive for both HBeAg/1 and HBeAg/2 in serum than in those positive for only HBeAg/1 or negative for both subtypes. These results suggest that the presence of HBeAg/2 in serum may reflect the occurrence of active viral replication. When the detection pattern of HBeAg subtypes was examined during serial follow-up for at least 1 year, three groups of patients were classified with respect to the presence of HBeAg/2, i.e., Type I, consistently positive for HBeAg/2; Type II, consistently negative for HBeAg/2, and Type III, intermittently positive for HBeAg/2. More than 80% of Type I patients were histologically diagnosed having as nonspecific reactive hepatitis, while more than 80% of Type II and III patients had more progressive liver diseases such as chronic persistent hepatitis, chronic active hepatitis and liver cirrhosis. These results suggest that the serial examination of HBeAg subtypes in serum may be important for more detailed evaluations of type B hepatitis.

show abstract

Section: Discussionmentioning

confidence: 99%

Virological significance of HBeAg subtypes (HBeAg/1 and HBeAg/2) in patients with type B hepatitis

et al. 1987

View full text Add to dashboard Cite

show abstract

“…The results might indicate that the presence of pHSA-R could be considered as an active viral replication marker that can be used to monitor antiviral therapy or to identify highly infectious material. Recently, Masuko et al (21) demonstrated that inocula responsible for HBV infection exhibited significantly higher levels of HBV-DNAp, HBsAg ad pHSA-R titers than did noninfectious samples. Our study stresses that at similar HBeAg titer ranks, HBV-DNAp positive patients had higher pHSA-R titers than those who were negative.…”

Section: Discussionmentioning

confidence: 99%

Hemagglutination and Immunofluorescence Studies on Polymerized Human Serum Albumin Binding Activity in Chronic Hepatitis B Virus Infection

et al. 1986

View full text Add to dashboard Cite

The binding activity of polymerized human serum albumin was determined in 202 HBsAg carriers. The presence of polymerized human serum albumin receptor sites was tested by hemagglutination and differentiated from antihuman albumin antibodies by immunofluorescence, isolation of IgG and IgM fractions and testing of HBsAg anti-HBs immune complexes. A granular pattern with anti-HBs was specific for polymerized human serum albumin receptor sites as demonstrated with purified HBsAg. In addition, a linear pattern with fluoresceinated antihuman immunoglobulins might suggest the presence of antihuman albumin antibodies (which was generally due to an IgG antibody). However, a granular pattern with fluoresceinated antihuman immunoglobulins may indicate the presence of HBsAg anti-HBs immune complexes. A weak linear pattern was also observed simultaneously in these cases, probably due to IgM antihuman albumin antibodies or an antipolymerized human serum albumin receptor site antibody. Of 202 HBsAg-positive patients, 71 showed polymerized human serum albumin receptor sites activity. The highest percentage of polymerized human serum albumin receptor sites was found among patients showing HBeAg and hepatitis B virus DNA polymerase positivity (96%), followed by HBeAg positivity and hepatitis B virus DNA polymerase negativity (48%), and anti-HBe positivity and hepatitis B virus DNA polymerase negativity (17%). In addition, a significant correlation between polymerized human serum albumin titers and hepatitis B virus DNA polymerase was found (r = 0.573, p less than 0.01). However, at similar HBeAg titer, patients who were positive for hepatitis B virus DNA polymerase had a higher polymerized human serum albumin receptor sites titer than those who were negative for hepatitis B virus DNA polymerase.(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract

“…In an extensive eight-year Japanese study involving 357 needle-stick accidents among 349 hospital employees, only four individuals developed hepatitis; hepatitis was accompanied by anti-c 100 HCY seroconversion in only three (76). It was concluded that the risk of developing HCY infection after an accidental needle stick involving antic 100 HCY-positive persons is exceedingly low compared to the 88% risk found among recipients of anti-c I00 HCY-positive blood units (7) and the 20% to 67% risk found in needle-stick accidents involving hepatitis Be antigen-positive blood (77).…”

Section: Hepatitis C In Hospital Employees With Needle-stick Injuriesmentioning

confidence: 94%

If You Cannot Grow it, Clone it! Hepatitis C Update

Marengo-Rowe

1992

Baylor University Medical Center Proceedings

View full text Add to dashboard Cite

Factors Influencing Postexposure Immunprophylaxis of Hepatitis B Virus Infection With Hepatitis B Immune Globulin

Cited by 23 publications

References 19 publications

Virological significance of HBeAg subtypes (HBeAg/1 and HBeAg/2) in patients with type B hepatitis

Virological significance of HBeAg subtypes (HBeAg/1 and HBeAg/2) in patients with type B hepatitis

Hemagglutination and Immunofluorescence Studies on Polymerized Human Serum Albumin Binding Activity in Chronic Hepatitis B Virus Infection

If You Cannot Grow it, Clone it! Hepatitis C Update

Contact Info

Product

Resources

About