Factors Influencing Salvage Cystectomy Results

Abstract

Analysis of 86 patients who underwent salvage cystectomy following a radical course of radiotherapy for bladder cancer and 37 patients who underwent primary cystectomy has shown a greater survival for women than men. The following factors were associated with a significant deterioration in survival: 1. Age at time of cystectomy: post-operative mortality and tumour recurrence are greater over the age of 70. 2. Non-function of one kidney on IVU. 3. Grade 3 tumour on cystectomy specimen. 4. pT3 or pT4 tumour on cystectomy specimen.

Salvage cystectomy after failure of interstitial radiotherapy and external beam radiotherapy for bladder cancer

“…Determining rcT is known to be hindered by the desmoplastic reaction and obliteration of anatomical planes, resulting in substantial under‐staging [13,15]. MRI and CT are useful to exclude involvement of adjacent organs and gross lymph node metastases, but differentiation between tumour infiltration and radiation fibrosis is less precise [16].…”

A model to predict the outcome of the bilharzial bladder cancer patient after radical cystectomy

“…Most prognostic studies of bladder cancer have dealt with survival (Osborn et al, 1982;England et al, 1981;Kishi et al, 1981;Cifuentes Delatte et al, 1982) and a minority with recurrence or metastasis (Dalesio et al, 1983;Pocock et al, 1982). Moreover these prognostic studies have generally been concerned with 'Western' bladder cancer (Osborn et al, 1982;Dalesio et al, 1983;Pocock et al, 1982) while few studies have dealt with bilharzial bladder cancer (Ghoneim et al, 1972(Ghoneim et al, ,1976(Ghoneim et al, ,1979Sherif and Ibrahim, 1983 England et al, 1981;Ghoneim et al, 1972Ghoneim et al, ,1976Smith & Whitmore, 1981;Varkarakis et al, 1975;Ballanger & Ballanger, 1982). Our study did not prove the prognostic value of multiplicity or histopathology of the tumour; some authors concur with this conclusion while others dissent (Ghoneim et al, 1979;Kishi et al, 1981).…”