Factors influencing survival after resection of pulmonary metastases from colorectal cancer

Vogelsang, H.; Haas, Sylvia; Hierholzer, Christian; Berger, Ursula; Siewert, J. R.; Präuer, H

doi:10.1002/bjs.4602

Cited by 114 publications

(54 citation statements)

References 24 publications

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“…farrow-to-finish farms), and in consequence is a good tool to better know the importance of some variables in different conditions. The use of regression trees in biomedical disciplines is increasing and it is being used to classify probable outcomes for diseases [5,18] or to figure out the relevance of genetic markers [13]. This technique is also useful to classify behaviour or habitude patterns that allow the identification of target segments of the population to whom a specific message can be addressed effectively [1] having thus a sociologic value.…”

Section: Discussionmentioning

confidence: 99%

Factors associated with routine mass antimicrobial usage in fattening pig units in a high pig-density area

et al. 2007

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-One hundred and seven fattening pig units randomly selected in Catalonia (Spain) were surveyed during 2001−2003, in order to determine the frequency of the prophylactic use of antimicrobials and mass treatments against respiratory and enteric disease outbreaks. Logistic regression and regression tree analysis were done to determine the factors associated with the on-farm mass antimicrobial usage. Fifty-eight per cent of the surveyed farms used mass antimicrobial prophylaxis; among them, 39% used two or more antimicrobials. The more frequently administered drugs were colistin, beta-lactams and tetracyclines. Fattening units from strict finishing farms were more likely to use antimicrobials than farrow-to-finish farms (Odds Ratio = 11.7) and farms with changing facilities were less likely to use these compounds (OR = 0.17). In the event of a respiratory disease outbreak, most farms applied mass treatment and 46% used two or more compounds, with tetracyclines, beta-lactams and sulphonamides being the most popular ones. Mass treatment with several compounds in case of respiratory problems was significantly related to the use of growth promoters on the farm (OR = 4.3). If an outbreak of an enteric disease occurred, most farms resorted also to a mass treatment and 48% used two or more drugs. The most frequent antimicrobial agent for the treatment of enteric disease was colistin. Fattening farms (OR = 6.9) and operations that perform routine antimicrobial prophylaxis (OR = 2.0) were more likely to use more than one antimicrobial agent for enteric diseases.antimicrobial agents / fattening pig units / prophylactic usage / regression tree

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Section: Discussionmentioning

confidence: 99%

Factors associated with routine mass antimicrobial usage in fattening pig units in a high pig-density area

et al. 2007

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“…However, approximately two-thirds of all NSCLC patients are ineligible for curative resection due to tobacco-related comorbidity, concomitant extrapulmonary diseases and/or advanced age [3,4]. Surgery is excluded in a similar percentage of pulmonary CRC-METs patients due to the presence of multifocal disease [5]. In any case, the surgical approach is by no means free from complications, including mortality, and it is difficult to repeat for recurrences [6,7].…”

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confidence: 99%

Percutaneous computed tomography-guided radiofrequency thermal ablation of small unresectable lung tumours

et al. 2006

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The aim of the current study was to evaluate the safety and the efficacy of radiofrequency thermal ablation (RFTA) for the treatment of nonsmall cell lung cancer (NSCLC) and isolated pulmonary metastases (METs) from colorectal cancer (CRC).A total of 31 patients (15 with NSCLCs and 16 with CRC lung METs), with 36 lung tumour nodules (mean¡SD diameter: 22¡8 mm, range: 10-35 mm) underwent computed tomography (CT)-guided RFTA using expandable electrodes. Contrast-enhanced CT was performed before and after (immediately and 30¡5 days) each RFTA session to assess immediate results and complications and repeated 3 and 6 months post-RFTA, as well as every 6 months thereafter, to evaluate long-term results. Complete radiological necrosis was defined as a nonenhancing area at the tumour site that was equal to or larger than the treated tumour; persistence of enhancement at the tumour site indicated incomplete treatment. Local recurrence was defined as an increase in tumour size and/or enhancing tissue at the tumour site.Complete radiological necrosis of the 36 tumours was achieved with 39 RFTA sessions and 42 electrode insertions. No major complications or deaths were observed. Six patients experienced mild-to-moderate pain during the procedure. There were five cases of pneumothorax, none requiring drainage and four cases of pneumonia, which were successfully treated with antibiotics. After a mean follow-up of 11.4¡7.7 months (range of 3-36 months), the overall local recurrence rate was 13.9% (20 and 9.5% for NSCLC and CRC-METs patients, repectively). Nineteen of the 31 (61.3%) patients were alive (15 apparently disease free) and 12 (38.7%) had died (three from causes unrelated to their cancer).Radiofrequency thermal ablation seems to be a safe, effective method for producing complete ablation of small nonsmall cell lung cancers and pulmonary colorectal cancer metastases.

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“…For example deep organ cancers are often misclassified, and metastatic sites are sometimes reported as primary cancers when cancer history is not confirmed from medical records [29, 30]. This misreporting of metastatic sites as primary cancers may partially explain the familial co-aggregation we detected of lung and colorectal cancers since the lung is a frequent site of metastasis from the colon [31]. If there is greater misclassification of disease for unaffected probands compared to those who report a cancer history, then there may be an additional source of bias.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Co-Aggregation of Cancer Based on Registry Data

Matthews

Betensky

Anton‐Culver

et al. 2006

Public Health Genomics

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Objective: An exploratory analysis of co-aggregation of cancers using registry-based data. Methods: We utilized sibships from over 18,000 families who had been recruited to the NCI-sponsored multi-institutional Cancer Genetics Network. The analysis assesses co-aggregation at the individual and family level and adjusts for ascertainment. Results: We found statistically significant familial co-aggregation of lung cancer with pancreatic (adjusted p < 0.001), prostate (adjusted p < 0.003), and colorectal cancers (adjusted p = 0.004). In addition, we found significant familial co-aggregation of pancreatic and colorectal cancers (adjusted p = 0.018), and co-aggregation of hematopoietic and (non-ovarian) gynecologic cancers (adjusted p = 0.01). Conclusion: This analysis identified familial aggregation of cancers for which a genetic component has yet to be established.

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Factors influencing survival after resection of pulmonary metastases from colorectal cancer

Abstract: Subgroup analysis provided criteria for the selection of patients for R0 resection of lung metastases from colorectal cancer and differentiated between those at high or low risk of early tumour progression; the latter patients would benefit most from surgery.

Cited by 114 publications

References 24 publications

Factors associated with routine mass antimicrobial usage in fattening pig units in a high pig-density area

Factors associated with routine mass antimicrobial usage in fattening pig units in a high pig-density area

Percutaneous computed tomography-guided radiofrequency thermal ablation of small unresectable lung tumours

Analysis of Co-Aggregation of Cancer Based on Registry Data

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