Factors influencing survival in myelodysplastic syndromes in a Brazilian population: comparison of FAB and WHO classifications

Lorand-Metze, Irene; Pinheiro, Mariana; Ribeiro, Evandro Marcos Saidel; Paula, Erich Vinícius De; Metze, Konradin

doi:10.1016/j.leukres.2003.11.001

Cited by 56 publications

(34 citation statements)

References 33 publications

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“…But a causal relationship cannot be postulated at the moment, since this study did not include a treatment-free control-group due to ethical reasons. An important factor for the occurrence of adverse events in this prospective investigation was the season, which has shown to be important in human (Metze et al, 1994;Lorand-Metze et al, 1998), as well in veterinary medicine (Brown-Brandl et al, 2005;Lacetera et al, 2005). Recently, it had been demonstrated that during hot and rainy months CTVT remission was delayed (Scarpelli et al, 2010), which might be due to a seasonal modulation of the immune system.…”

Section: Discussionmentioning

confidence: 86%

“…Performance status or quality of life scores are important in human medicine (Lorand-Metze et al, 2004), but also of increasing interest in veterinary sciences (Hahn et al, 1994;Yazbek and Fantoni, 2005). Performance scores are applied for pre-treatment evaluations of oncologic patients, since they have shown to be predictive for therapy outcome.…”

Section: Introductionmentioning

confidence: 99%

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Clinical utility of a life quality score in dogs with canine transmissible venereal tumor treated by vincristine chemotherapy

Valladão

Scarpelli

Metze

2010

Arq. Bras. Med. Vet. Zootec.

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The clinical utility of a life quality score during vincristine chemotherapy of dogs with canine transmissible venereal tumor (CTVT) was investigated using 93 tumor-bearing dogs in this prospective study. At diagnosis, clinical data and the performance status were evaluated according to a modified Karnofsky score (CKS) adapted for dogs. The animals were treated with vincristine sulphate (0.025mg/kg) at weekly intervals until the tumor had macroscopically disappeared. The time until the first adverse event and death were recorded. In a pilot study, CKS revealed a high inter-observer concordance (kappa=0.735; weighted kappa=0.835). CKS permitted a detailed monitoring of adverse effects during therapy. Cox regressions showed that low performance score and reduced body weight were independent predictive factors for death during chemotherapy. The modified Karnofsky performance score is a simple and reproducible clinical instrument, able to estimate patient outcome after treatment of CTVT.Keywords: canine transmissible venereal tumor, vincristine, survival, performance score, quality of life RESUMO Investigou-se a utilidade clínica de uma escala de qualidade de vida durante o tratamento quimioterápico de cães com tumor venéreo transmissível canino (TVTC) em 93 animais com TVTC que compuseram este estudo prospectivo. Ao diagnóstico, foram avaliados os dados clínicos e o escore de qualidade de vida adaptado para cães (CKS). Os animais foram tratados

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Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Clinical utility of a life quality score in dogs with canine transmissible venereal tumor treated by vincristine chemotherapy

Valladão

Scarpelli

Metze

2010

Arq. Bras. Med. Vet. Zootec.

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“…32 (13) 2 (7) 6 (20) 5 (9) 12 (40) 5 (23) 62 (25) (13) 3 (5) 6 (20) 2 (9) 25 (6) 20 9 CMML 32 (12) 1 (4) 4 (13) 6 (11) 3 (10) 3 (14) 49 (12) 15 (7) 12 (48) 2 (10) 4 (11) 2 (11) 1 (6) 36 (11) (12) 4 (16) 4 (20) 7 (16) 3 (16) 2 (13) 44 (13) 28 26 RAEB-II 31 (15) 1 (8) 6 (30) 6 (14) 11 (6) differences in classification, and the inclusion/exclusion of therapy-related MDS, AML, or of pediatric cases. Several differences have been reported between western and Asian groups, but, little is known about the epidemiological patterns of MDS in Latin American regions [8,12,[21][22][23]. Most series usually include patients classified according to FAB.…”

Section: Discussionmentioning

confidence: 99%

Partial and total monosomal karyotypes in myelodysplastic syndromes: Comparative prognostic relevance among 421 patients

et al. 2011

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Myelodysplastic syndromes (MDS) include a group of heterogeneous hematological disorders with a variable risk of leukemic evolution and short survival. Around 40-50% of patients show abnormal karyotypes that are mostly characterized by monosomies or deletions. Cytogenetic findings are an independent prognostic factor and the International prognostic scoring system (IPSS) differentiates three cytogenetic categories, despite the Intermediate one being heterogeneous. The aim of this study, including 421 Argentinean patients with primary MDS, is to characterize the cytogenetic profile, to test its prognostic value and to compare partial and monosomal karyotypes against other cytogenetic findings. An abnormal karyotype (median survival: 26 months) was observed in 176 patients. The presence of complex karyotypes, number of alterations, and the IPSS cytogenetic groups showed significant differences for predicting outcome. Behavior of patients with isolated deletions (median survival: 49 months) did not differ from those with normal karyotype (56 months, P 5 0.654) or Good prognostic findings (43 months, P 5 0.371). However, a worse prognosis was observed when another alteration was added (31 months, P 5 0.043). Karyotypes with autosomal monosomies (median survival: 16 months) had a prognostic impact similar to other Poor cytogenetic findings (17 months, P 5 0.626). In our population classified according to French-American-British (FAB) or World Health Organization (WHO), this new categorization of cytogenetic abnormalities, recognizing three different risk groups, showed an independent prognostic impact and a better discriminating power than the IPSS categories. It can be concluded that all isolate deletions (excluding 7q-) are good prognostic findings and all monosomies (excluding Y chromosome loss) are bad indicators. Am. J. Hematol. 86:540-545, 2011. V

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“…[7][8][9]12 In our previous report, 12 the concordance rate of morphological diagnosis according to the WHO classification between Japanese and German hematologists was 83.8%, and a significant concordance was achieved while using the WHO classification (k 0.73, Po0.001). Therefore, we believe that the evaluation of the frequency of dysmyelopoiesis is comparable between Japanese and German hematologists.…”

Section: Discussionmentioning

confidence: 99%

“…It was reported that RCMD patients showed a more unfavorable prognosis than WHO-RA patients. [7][8][9] The criteria for RCMD include a uniform threshold of 10% for dysplasia in each lineage. However, the impact of this threshold on prognosis has not been fully assessed.…”

Section: Introductionmentioning

confidence: 99%

Improvement of criteria for refractory cytopenia with multilineage dysplasia according to the WHO classification based on prognostic significance of morphological features in patients with refractory anemia according to the FAB classification

et al. 2007

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In the criteria of refractory cytopenia with multilineage dysplasia (RCMD) according to the WHO (World Health Organization) classification, the frequency threshold concerning dysplasia of each lineage was defined as 10%. To predict overall survival (OS) and leukemia-free survival (LFS) for patients with refractory anemia (RA) according to the French-American-British (FAB) classification, we investigated prognostic factors based on the morphological features of 100 Japanese and 87 German FAB-RA patients, excluding 5q-syndrome. In the univariate analysis of all patients, pseudo-Pelger-Huet anomalies X10% (Pelger þ ), micromegakaryocytes X10% (mMgk þ ), dysgranulopoiesis (dys G) X10% and dysmegakaryopoiesis (dys Mgk) X40% were unfavorable prognostic factors for OS and LFS (OS; Po0.001, LFS; Po0.001). The prognostic effects of the morphological features were similar in both Japanese and German patients. However, dys Mgk X10% was not correlated with OS and LFS. In the multivariate analysis, mMgk þ and dys MgkX40% were adverse prognostic factors for OS for all patients, and dys G X10% and dys MgkX40% were adverse prognostic factors for LFS for all patients. On the basis of the present analysis, we propose the following modified morphological criteria for RCMD. Modified RCMD should be defined as FAB-RA, excluding 5q-syndrome with dys G X10%, dys MgkX40% or mMgk þ .

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Factors influencing survival in myelodysplastic syndromes in a Brazilian population: comparison of FAB and WHO classifications

Cited by 56 publications

References 33 publications

Clinical utility of a life quality score in dogs with canine transmissible venereal tumor treated by vincristine chemotherapy

Clinical utility of a life quality score in dogs with canine transmissible venereal tumor treated by vincristine chemotherapy

Partial and total monosomal karyotypes in myelodysplastic syndromes: Comparative prognostic relevance among 421 patients

Improvement of criteria for refractory cytopenia with multilineage dysplasia according to the WHO classification based on prognostic significance of morphological features in patients with refractory anemia according to the FAB classification

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