Factors Influencing the Absorption of Water and Chlorides From the Intestine

Rabinovitch, Jacob

doi:10.1152/ajplegacy.1927.82.2.279

Cited by 26 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In support, it was earlier observed that after exposure to stilbene the unidirectional C1-fluxes were equal [31]. In agreement with the view that the luminal [C1] should decline substantially, Rabinovitch observed that the luminal [C1] fell to as low as 34 mM (i.e., 0.2% NaC1) in in-vivo intestinal loops of dog duodenum [24]. The power of intestinal active C1 transport was dramatically illustrated in the work of Ingraham and Visscher who demonstrated that the luminal [C1] fell to 0.4 mM (corresponding to a blood-to-lumen [C1] gradient of 250:1 !)…”

Section: Theoretical CL Gradient Achieved By Intestinal Mucosasupporting

confidence: 78%

Modes of Cl− transport across the mucosal and serosal membranes of urodele intestinal cells

White¹

1986

J. Membrain Biol.

View full text Add to dashboard Cite

The characteristics of Cl- movement across luminal and basolateral membranes of Amphiuma intestinal absorptive cells were studied using Cl(-)-sensitive microelectrodes and tracer 36Cl techniques. Intracellular Cl- activity (aiCl) was unchanged when serosal Cl- was replaced; when luminal Cl- was replaced cell Cl- was rapidly lost. Accordingly, the steady state aiCl could be varied by changing the luminal [Cl]. As luminal [Cl] was raised from 1 to 86 mM, aiCl rose in a linear manner, the mucosal membrane hyperpolarized, and the transepithelial voltage became serosa negative. In contrast, the rate of Cl- transport from the cell into the serosal medium, measured as the SITS-inhibitable portion of the Cl- absorptive flux, attained a maximum when aiCl reached an apparent value of 17 mM, indicating the presence of a saturable, serosal transport step. The stilbene-insensitive absorptive flux was linear with luminal [Cl], suggestive of a paracellular route of movement. Intracellular aCl was near electrochemical equilibrium at all but the lowest values of luminal [Cl] after interference produced by other anions was taken into account. aiCl was unaffected by Na replacement, removal of medium K, or elevation of medium HCO-3. Mucosae labeled with 36Cl lost isotope into both luminal and serosal media at the same rate and from compartments of equal capacity. Lowering luminal [Cl] or addition of theophylline enhanced luminal Cl- efflux. It is concluded that a conductive Cl leak pathway is present in the luminal membrane. Serosal transfer is by a saturable, stilbene-inhibitable pathway. Luminal Cl- entry appears to be passive, but an electrogenic uptake cannot be discounted.

show abstract

Section: Theoretical CL Gradient Achieved By Intestinal Mucosasupporting

confidence: 78%

Modes of Cl− transport across the mucosal and serosal membranes of urodele intestinal cells

White¹

1986

J. Membrain Biol.

View full text Add to dashboard Cite

show abstract

“…Other more physiologically oriented data suggest that the relationship of drinking behavior to different concentrations of salt solution may be governed by variations in the capacity of the gastric tract to handle these concentrations. Experiments on the rate of absorption of various salt solutions placed directly in the duodenum, for example, show that maximum absorption occurs with approximately isotonic solutions, and falls off as the concentration of solution is both increased and decreased (5). This absorption curve very strikingly resembles the preference-aversion curve of the normal animal for sodium chloride, and suggests the possibility that the rate of absorption of solutions from the duodenum might have something to do with preference and aversion.…”

mentioning

confidence: 92%

Gastric factors controlling water- and salt-solution-drinking.

Stellar¹,

Hyman²,

Samet³

1954

Journal of Comparative and Physiological Psychology

111

View full text Add to dashboard Cite

“…The reduction of absorption of isotopic water and Na in healthy humans after administration of banthine or propantheline was considered to be due to hypomotility (Higgins, Code & Orvis, 1956;Groisser & Farrar, 1960. However, with diminution ofmotility by subcutaneous administration of atropine to dogs (Rabinovitch, 1927;Tidball & Tidball, 1950;Blickenstaff, 1952), or by intravenous injection to rats (Hubel, 1976) and humans (Morris & Turnberg, 1980), water absorption was increased. In the rat jejunum in vitro, water absorption was found to occur almost entirely via the lymphatic system, and motility increased lymph flow, lymph pressure and water absorption by about 100 % (Lee, 1965(Lee, , 1969.…”

Section: Introductionmentioning

confidence: 99%

Relationship between intestinal motility, tone, water absorption and lymph flow in the rat.

Lee¹

1983

The Journal of Physiology

View full text Add to dashboard Cite

SUMMARY1. The relations between motility, tone, water absorption rate (J,) and lymph flow (J,), were studied in an exteriorized upper jejunal preparation in vivo, with its serosal side bathed in Krebs-Ringer or other solutions. Neither J, nor J, was correlated with motility.2. When the luminal fluid consisted of an isotonic solution of MgSO4, glucose or LiCl, motility was greatly increased with no increase in J1.3. When the serosal fluid consisted of an isotonic solution of mannitol, glucose or MgSO4, motility was depressed with a large decrease in tone, and J, was increased by 51-83 % with a decrease in J,. When the serosal fluid consisted of an isotonic solution of NaCl, Na2SO4, LiCl or KCl, motility was decreased with either no change or an increase in tone, and both J, and J, were much decreased. When isotonic cholihe Cl solution was employed as the serosal fluid, motility increased with an increase in tone, J, became negative (fluid secretion), and J, decreased to 0. 4. Acetylcholine depressed motility but increased tone with a decrease in Jv and J,. Eserine increased both tone and motility with a decrease in Jv and Ji. Serotonin caused no change in motility but increased tone with a decrease in J4 and J,.Noradrenaline and adrenaline depressed motility and reduced tone with an increase in Jv and Ji. Isoprenaline abolished motility and reduced tone with a large increase in Jv but no change in J,. Pentobarbitone depressed motility and reduced tone with an increase in Jv but a decrease in J,.5. It is concluded that the intestine responds to various stimuli with a change in motility, or tone, or both. Intestinal motility per se does not produce lymph. Since an increase or decrease in tone always results in a decrease or increase in J, respectively, regardless of the nature of the conditions, a relaxation of the intestinal musculature appears to be associated with an increase in water absorption.

show abstract

Factors Influencing the Absorption of Water and Chlorides From the Intestine

Cited by 26 publications

References 0 publications

Modes of Cl− transport across the mucosal and serosal membranes of urodele intestinal cells

Modes of Cl− transport across the mucosal and serosal membranes of urodele intestinal cells

Gastric factors controlling water- and salt-solution-drinking.

Relationship between intestinal motility, tone, water absorption and lymph flow in the rat.

Contact Info

Product

Resources

About