Factors influencing the absorption of vitamin D in GIT: an overview

Maurya, Vaibhav Kumar; Aggarwal, Manjeet

doi:10.1007/s13197-017-2840-0

Cited by 112 publications

(119 citation statements)

References 69 publications

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“…This could be important as adequate concentrations of lipids, bile salts and fatty acids are required for incorporation of fat-soluble vitamin D into mixed micelles, as a prerequisite for its absorption 79 , 80 . Thus, increased abundance of bacterial genes related to lipid and fatty acid metabolism post supplementation could indicate increased vitamin D bioavailability and absorption in the gut 81 .…”

Section: Discussionmentioning

confidence: 99%

The potential role of vitamin D supplementation as a gut microbiota modifier in healthy individuals

Singh

Rawat

Alwakeel

et al. 2020

Sci Rep

143

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Vitamin D deficiency affects approximately 80% of individuals in some countries and has been linked with gut dysbiosis and inflammation. While the benefits of vitamin D supplementation on the gut microbiota have been studied in patients with chronic diseases, its effects on the microbiota of otherwise healthy individuals is unclear. Moreover, whether effects on the microbiota can explain some of the marked inter-individual variation in responsiveness to vitamin D supplementation is unknown. Here, we administered vitamin D to 80 otherwise healthy vitamin D-deficient women, measuring serum 25(OH) D levels in blood and characterizing their gut microbiota pre- and post- supplementation using 16S rRNA gene sequencing. Vitamin D supplementation significantly increased gut microbial diversity. Specifically, the Bacteroidetes to Firmicutes ratio increased, along with the abundance of the health-promoting probiotic taxa Akkermansia and Bifidobacterium. Significant variations in the two-dominant genera, Bacteroides and Prevotella, indicated a variation in enterotypes following supplementation. Comparing supplementation responders and non-responders we found more pronounced changes in abundance of major phyla in responders, and a significant decrease in Bacteroides acidifaciens in non-responders. Altogether, our study highlights the positive impact of vitamin D supplementation on the gut microbiota and the potential for the microbial gut signature to affect vitamin D response.

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Section: Discussionmentioning

confidence: 99%

The potential role of vitamin D supplementation as a gut microbiota modifier in healthy individuals

Singh

Rawat

Alwakeel

et al. 2020

Sci Rep

143

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“…There are three known transporters: SRBI (scavenge receptor class B type 1), CD 36 (cluster determinant 36) and NPC1L1 (Neimann–Pick C1‐like 1), but the differences between absorption rate in the duodenum and the jejunum indicates the presence of another transporter, particularly expressed in the jejunum. Several other factors influence the bioavailability of vitamin D like nutrient status in the host, form, food matrix, amount, and composition of ingested food, amount of lipids, type of fatty acids, dietary fibers, activities of digestive enzymes, efficiency of transport across enterocytes, interactions with micronutrients, age of host, obesity, genetic variations, and therefore, contribute to the interindividual variability of vitamin D absorption . Beside the absorption of vitamin D, also the endogenous synthesis varies, depending on the type and nature of skin pigments and the age of the host, as the vitamin D production in the skin, as well as the conversion of 25OHD into 1,25(OH)2D (active form) in the kidneys, decreases with age…”

Section: Vitaminsmentioning

confidence: 99%

GutSelf: Interindividual Variability in the Processing of Dietary Compounds by the Human Gastrointestinal Tract

Walther

Lett

Bordoni

et al. 2019

Molecular Nutrition Food Res

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Nutritional research is currently entering the field of personalized nutrition, to a large extent driven by major technological breakthroughs in analytical sciences and biocomputing. An efficient launching of the personalized approach depends on the ability of researchers to comprehensively monitor and characterize interindividual variability in the activity of the human gastrointestinal tract. This information is currently not available in such a form. This review therefore aims at identifying and discussing published data, providing evidence on interindividual variability in the processing of the major nutrients, i.e., protein, fat, carbohydrates, vitamins, and minerals, along the gastrointestinal tract, including oral processing, intestinal digestion, and absorption. Although interindividual variability is not a primary endpoint of most studies identified, a significant number of publications provides a wealth of information on this topic for each category of nutrients. This knowledge remains fragmented, however, and understanding the clinical relevance of most of the interindividual responses to food ingestion described in this review remains unclear. In that regard, this review has identified a gap and sets the base for future research addressing the issue of the interindividual variability in the response of the human organism to the ingestion of foods.

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“…Increasing age, obesity, malabsorptive conditions, and genetic variation in protein mediated transport, lipase and vitamin D binding protein levels can impair absorption of Vit-D. The bioavailability of Vit-D in the gastrointestinal tract can also be affected by differences in food matrix and the physiochemical state of Vit-D. Changes in the pH and concentration of bile salts also influence the absorption of Vit-D [10] .…”

Section: Case Presentationmentioning

confidence: 99%

Sublingual Vitamin D3 Effective In A Patient Resistant To Conventional Vitamin D Supplementation

Faisal

Mirza

2020

AACE Clinical Case Reports

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INTRODUCTION: Vitamin D deficiency is quite prevalent worldwide and is usually treated with oral supplementation. Bioavailability of Vitamin D may differ among individuals due to variable absorption and metabolism in the body. CASE PRESENTATION: 66-year-old woman presented for evaluation of low 25(OH)D level. She had no known prior history of gastric/intestinal surgeries or malabsorptive conditions. She had previously been treated with vitamin D3, 2000 IU by mouth (PO) daily with poor response and then vitamin D2 50,000 weekly PO, with persistently low 25(OH)D level at 14 ng/ml after 8 weeks of treatment. Celiac screen was negative and duodenal biopsy was normal. Due to demonstration of poor oral absorption, she was prescribed vitamin D2 50,000 units sublingually for 8 weeks and then changed to over the counter vitamin D3 drops sublingually (1000 units/drop) at 4000 unit twice daily due to suboptimal response with vitamin D2. 25(OH)D level improved gradually to 28 ng/ml after 12 weeks on this regimen and was at 37 ng/ml at 1 year. CONCLUSION: Sublingual vitamin D3 may be an effective alternative mode of vitamin D supplementation in patients who demonstrate poor oral vitamin D absorption despite adequate supplementation for various reasons.

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Factors influencing the absorption of vitamin D in GIT: an overview

Cited by 112 publications

References 69 publications

The potential role of vitamin D supplementation as a gut microbiota modifier in healthy individuals

The potential role of vitamin D supplementation as a gut microbiota modifier in healthy individuals

GutSelf: Interindividual Variability in the Processing of Dietary Compounds by the Human Gastrointestinal Tract

Sublingual Vitamin D3 Effective In A Patient Resistant To Conventional Vitamin D Supplementation

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