Relevance. The problem of tissue regeneration in diabetic foot syndrome has currently become particularly relevant due to the multipolarity of the mechanisms of trophic disorders, their tendency to recur, the expansion of the affected areas when using traditional treatment methods, resistance to drug treatment methods, deterioration of patients' quality of life, as well as due to the significant expenditure of time and effort required for treatment. All these factors lead to significant economic costs in the management of patients in this cohort.The aim of the study: to develop new combined methods of surgical treatment of tissue defects in patients with complicated forms of diabetic foot syndrome.Materials and methods. The paper presents an original approach to solving one of the urgent problems of modern surgery of complications of diabetes mellitus, to the treatment of pathological processes of soft tissues of the lower extremities.Conclusions. At the stages of the entire study period, rapid wound healing was registered regardless of the initial clinical data and patient's medical history. There was also a decrease in the inflammatory response and active restoration of damaged tissues.