Factors influencing the development of serum precipitins to farmer's lung antigen in Quebec dairy farmers.

Cormier, Yvon; Bélanger, Jacques; Durand, P.

doi:10.1136/thx.40.2.138

Cited by 101 publications

(36 citation statements)

References 13 publications

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“…Thus certain subjects with indirect or low levels of exposure may have been included in the nonexposure group (misclassification error). The results on the role of precipitins as an exposure indicator concur with those of other authors (44)(45)(46).…”

Section: Discussionsupporting

confidence: 81%

Respiratory symptoms and pulmonary function of workers exposed to cork dust, toluene diisocyanate and conidia.

Alegre¹,

Morell²,

Pleguezuelos³

1990

Scand J Work Environ Health

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Section: Discussionsupporting

confidence: 81%

Respiratory symptoms and pulmonary function of workers exposed to cork dust, toluene diisocyanate and conidia.

Alegre¹,

Morell²,

Pleguezuelos³

1990

Scand J Work Environ Health

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“…Genetic markers have generally failed to confirm hereditary risk factors for HP (49,(135)(136)(137)(138)(139)(140)(141)(142)(143)(144). Recent studies have shown a polymorphism in the TNF-a )308 promoter which is associated with high production of TNF in patients with bird-fancierÕs lung.…”

Section: Promoting and Protective Factorsmentioning

confidence: 99%

“…In fact, only 1-15% of people exposed to HP antigen develop the disease while in some cases the majority of exposed individuals have a high titre of serum precipitating antibodies but they remain asymptomatic (48). For example, 10% of people exposed to Saccharopolyspora rectivirgula, the main agent for FarmerÕs lung, a well-described form of HP, develop antibodies again the actinomycete while only 0.3% will get the disease (49).…”

Section: Specific Antibodiesmentioning

confidence: 99%

Hypersensitivity pneumonitis

Girard

and

Cormier

2009

Allergy

116

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The first few cases of hypersensitivity pneumonitis (HP) were described in the early 20th century in farmers exposed to moldy hay or straw. As then, HP has been ascribed to multiple inhaled antigens found in a large variety of environmental settings. Hypersensitivity pneumonitis results from an exaggerated immune response, which gives rise to acute infection‐like symptoms or to progressive, sometimes irreversible lung damage. The diagnosis is based on a combination of clinical characteristics of the disease. Clinical diagnostic criteria have recently been published. The immune mechanisms leading to HP are still incompletely understood. Initially, believed to be a classes III and IV immune response, we now have a clearer understanding of the complex inflammatory events involved. These include the release of pro inflammatory cytokines and a decrease in the immune control mechanisms via surfactant, dendritic and T‐regulatory cells. Despite the improved understanding, the treatment and outcome of HP have not changed. Oral corticosteroids remain the only effective drugs and contact withdrawal constitutes the ideal solution. If unchecked, HP can lead to irreversible lung damage in the form of fibrosis or emphysema, respiratory insufficiency and even death.

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“…Long recognised by microbiologists, these actinomycetes are frequently responsible for a common form of hypersensitivity pneumonitis called 'farmer's lung' [ I]. Saccharupolyspura rectivirgula (Micrupolyspora faeni) is the species most frequently responsible for this condition in Eastern Canada [2]. S. rectivirgula has also been associated with a respiratorydisease in horses known as heaves [3].…”

Section: Introductionmentioning

confidence: 99%

Saccharopolyspora rectivirgula from Quebec dairy barns: application of simplified criteria for the identification of an agent responsible for farmer's lung disease

Duchaine¹,

Mériaux²,

Brochu

et al. 1999

Journal of Medical Microbiology

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Saccharopolyspora rectivirgula (Micropolyspora faeni) is one of the major agents responsible for farmer's lung disease, a form of hypersensitivity pneumonitis. It is frequently isolated from the air of contaminated barns. The identification of this actinomycete is difficult because most of its phenotypic characteristics are variable and classical tests are not easy to perform on actinomycetes. Fatty acid analysis is very useful for the identification of these strains, but is not available except in some research or reference laboratories. Morphological (microscopic and macroscopic observations), physiological and biochemical tests (growth properties; macromolecules degraded; citrate utilisation and acid production from carbohydrates; resistance to antibiotics, lysozyme and heat), cell wall and fatty acid analyses and IgG analyses with serum from patients with farmer's lung were performed on 12 environmental isolates presumed to be S. rectivirgula and two control strains of S. rectivirgula. From this, a simple and rapid scheme for the identification of this actinomycete is proposed: optimal growth temperature (55°C); colony appearance based on morphology (filamentous) and colour (beige to orange-brown); microscopic morphology (chains of spores on both aerial and substrate mycelium); growth on NaCl 10%; cell-wall analysis (type IV); and the verification of antibody response with serum from a patient with farmer's lung. This last criterion is important to confirm the immunogenicity of the strains identified as S. rectivirgula. This scheme provides an accurate and efficient way of identifying S. rectivirgula strains and evaluating exposure to this bacterium. The study shows the limited value and the lack of reproducibility of some classical biochemical tests.

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Factors influencing the development of serum precipitins to farmer's lung antigen in Quebec dairy farmers.

Cited by 101 publications

References 13 publications

Respiratory symptoms and pulmonary function of workers exposed to cork dust, toluene diisocyanate and conidia.

Respiratory symptoms and pulmonary function of workers exposed to cork dust, toluene diisocyanate and conidia.

Hypersensitivity pneumonitis

Saccharopolyspora rectivirgula from Quebec dairy barns: application of simplified criteria for the identification of an agent responsible for farmer's lung disease

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