Factors Influencing the Growth of Staphylococci Localized in Cellophane Sacs in vivo. I. Comparative Diffusion and Antibacterial Effect of Three Penicillin Analogues

Factors Influencing the Growth of Staphylococci Localized in Cellophane Sacs in vivo. II. Influence of Variations in Time and Dose Relationships on Microbial Persistence

“…The technique of preparing and implanting the semipermeable cellophane sacs was as described in the previous paper (A bu-N assar, Yow, W illia m s, and Dolan, 1965). One sac was implanted in each animal.…”

“…A technique previously described by Gladstone and Glencross (1960) for the study of growth and toxin production of staphylococci using cellophane bags implanted in the peritoneal cavities of mice was modified for these experiments. Experiments designed to study the growth of bacteria, the diffusion of penicillin and the antibacterial effect of penicillin are reported in the preceding paper (A bu-Nassar, Yow, W illiams and Dolan, 1965). This paper deals with the effect of variations in intervals between doses on staphylococci in the persistent state.…”