Factors influencing the long-term success of periurethral collagen therapy in the office

Koduri, Sumana; Goldberg, Roger P.; Kwon, Christina; Dobrez, Deborah G.; Sand, Peter K.

doi:10.1007/s00192-005-0011-8

Cited by 9 publications

(8 citation statements)

References 33 publications

(37 reference statements)

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“…In a study with 184 female patients where collagen was used as the periurethral injection material [22], similar to our study, it is reported that the previous anti-incontinence treatment is an important factor contributing to the success of the treatment in the patients who had been reported 'cure' for more than one year after the injection. In this study, analyzing the affects of obesity, menopausal status, hormonal treatment and the type of the incontinence on the results, it was ascertained that they did not make a significant difference [22]. Even though the affects of obesity and post-menopausal status on the development of SUI in females is very well known, and their significance in the prediction of the success of the surgeries was researched in many studies, the affects of these factors in the results of transurethral injection treatment are not known very well.…”

Section: Discussionsupporting

confidence: 86%

“…After an 18 month follow-up, 398 patients were evaluated, and it was demonstrated that BMI did not have any affect on the surgery result, while menopausal status and age were found to be independent risk factors decreasing the success of the sling procedures [21]. In a study with 184 female patients where collagen was used as the periurethral injection material [22], similar to our study, it is reported that the previous anti-incontinence treatment is an important factor contributing to the success of the treatment in the patients who had been reported 'cure' for more than one year after the injection. In this study, analyzing the affects of obesity, menopausal status, hormonal treatment and the type of the incontinence on the results, it was ascertained that they did not make a significant difference [22].…”

Section: Discussionmentioning

confidence: 99%

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Efficiency of Injection Therapy for Stress Incontinence:a Retrospective Evaluation of 8 Years Results

Ener¹

2013

Ann Clin Anal Med

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ÖzetAmaç: Stres üriner inkontinansı olan seçilmiş kadın hastalarda, transüretral Coaptite® enjeksiyonunun etkinliğini ve BMİ, menopozal durum önceden geçi-rilmiş anti-inkontinans cerrahisinin prediktif değerini inceledik. Gereç ve Yön-tem: Genel anestezi açısından yüksek risk taşıyan, transüretral enjeksiyon tedavisi uygulanmış olan, stres üriner inkontinanslı 45 kadın hasta retrospektif olarak incelendi. Enjeksiyon sonrası dönemde 1. ay, 12. ay ve 8. yıl kontrollerinde ICIQ-SF, QoL skorları ve ped testi değerlendirmeleri yapıldı. Bulgular:Enjeksiyon öncesi dönemle karşılaştırıldığında, 1. ve 12. ay ped testi sonuçla-rı anlamlı, son kontroldeki ped testi sonucu ise anlamsız olarak bulundu. Sorgulama formları incelendiğinde, ped testine benzer şekilde enjeksiyon sonrası dönemdeki skorlar istatistiksel olarak anlamlı bulundu. Ancak ped testinden farklı olarak, her 2 sorgulama formunda da son kontroldeki skorların, istatistiksel olarak anlamlı değişiklikler gösterdiği tespit edildi. Transüretral enjeksiyon tedavisinin başarısı menopozal durum, BMİ ve önceden geçirilmiş antiinkontinans cerrahisine gore değerlendirildi. QoL ve ICIQ-SF skoru %değişim-leri ve ped testi değerleri, uzun dönem takipte, enjeksiyon öncesi dönemle karşılaştırıldığında, istatistiksel olarak anlamlı bulunmadı. Tartışma: Transü-retral enjeksiyon, SÜİ'ı olan seçilmiş hastalarda kolay ve etkili bir yöntemdir.BMİ, önceden geçirilmiş anti-inkontinans cerrahisi ve menopozal durum, uzun dönem takipte, transüretral enjeksiyon sonuçlarını etkilememektedir. Anahtar KelimelerSÜİ; Transüretral Enjeksiyon; VKİ; Geçirilmiş Anti-İnkontinans Cerrahisi; Menopozal Durum Abstract Aim: To evaluate the long term affectivity of transurethral Calcium Hydroxylapatite (CaHA; Coaptite®) injection therapy and the predictive importance of Body Mass Index (BMI), menopausal status and previous anti-incontinence surgery in selected female patients with stress urinary incontinence (SUI). Material and Method: Forty-five female patients with SUI, and having high risks for general anesthesia, received transurethal injection therapy, were evaluated retrospectively. First month, 12th month, and 8th year of postinjection period were evaluated in terms of International Consultatiton on Incontinence Questionnaire Short Form (ICIQ-SF), Quality of Life (QoL) score, and pad test. Results: While the pad test of 1st and 12th months' showed statistically significance, the pad test of last visit was found insignificant, when compared with pre-injection term. Through the evaluations of questionnaire forms similar to the pad test, it was observed that the post-injection scores showed statistically significance. However, unlike to the pad test, for each of both questionnaires, statistically significant differences were detected at the last examination's scores, as well. When we examined the success of the transurethral injection treatment according to menopausal status, BMI, and previous anti-incontinence surgery, it was observed that QoL and ICIQ-SF score %variation, and 24 hr pad test value...

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Efficiency of Injection Therapy for Stress Incontinence:a Retrospective Evaluation of 8 Years Results

Ener¹

2013

Ann Clin Anal Med

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“…This demonstrates a potential benefit in the elderly and in women with recurrent or persistent incontinence after previous surgery. Koduri et al [46] also found that previous anti-incontinence surgery was the one factor that showed a trend for negative stress tests over a year after injection [46]. Additionally, as it carries a low risk of long-term urinary retention and de novo urinary storage symptoms, some authors have suggested that injectable therapy may have a role in women at increased risk for these postoperative sequelae.…”

Section: Morbidity Of Injectable Therapymentioning

confidence: 95%

Bulking agents for stress urinary incontinence: Are they still indicated?

Haverkorn

Gomelsky

2008

Curr Bladder Dysfunct Rep

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Injectable bulking agents have been widely available for nearly 20 years, but their role in treating stress urinary incontinence (SUI) in women is poorly defined. Although safely and easily administered in the office or outpatient setting, injectable therapy has been associated with variable rates of success. Typically, success rates approach 70%, with fewer than half of these women achieving dryness. Multiple injections may also be necessary for optimum results. Despite few comparative studies, surgery appears to be more objectively effective than injectable therapy, although improvements in quality of life are similar. In light of this information, injectables maintain an important role in the treatment of SUI in properly selected patients who have undergone detailed discussion of goals and expectations.

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“…30 One RCT compared collagen injections to open surgery (fascial sling, Burch, or needle suspension) for SUI in 133 women. 13 At 1 year, 32.8% of patients were not satisfied with their procedure compared with 20.4% in the open surgery group.…”

Section: Collagen (3 Rcts)mentioning

confidence: 99%

The treatment of female stress urinary incontinence: an evidenced-based review

Pelletier-Cameron¹,

Haraway²

2011

RRU

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Objective: To review the literature on the surgical and nonsurgical treatment options for stress urinary incontinence in women, focusing exclusively on randomized clinical trials and high quality meta-analyses. Materials and methods: A computer-aided and manual search for published randomized controlled trials and high quality meta-analyses investigating both conservative and surgical treatment options for stress urinary incontinence. In the case of a treatment that is not studied in these formats large case series have been used. Results: Articles were reviewed and the results summarized on pelvic floor physical therapy, pharmacotherapy, bulking agents, and surgery (open and minimally invasive). Conclusion: There are numerous high quality studies in the literature. It can be difficult to make definitive conclusions on the most appropriate treatment options due to the variability in the outcomes used to define success in these articles. There is also a dire lack of studies evaluating and comparing the surgical options for patients with intrinsic sphincter deficiency.

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Factors influencing the long-term success of periurethral collagen therapy in the office

Cited by 9 publications

References 33 publications

Efficiency of Injection Therapy for Stress Incontinence:a Retrospective Evaluation of 8 Years Results

Efficiency of Injection Therapy for Stress Incontinence:a Retrospective Evaluation of 8 Years Results

Bulking agents for stress urinary incontinence: Are they still indicated?

The treatment of female stress urinary incontinence: an evidenced-based review

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