“Factors influencing the outcome of COVID-19 patients admitted in a tertiary care hospital, Madurai.- a cross-sectional study”

Priya, S; Meena, MSelva; Jayaraman, Srinivasan; Rathinam, Prabhakaran; Priyadharshini, C. Brinda; Anand, V. Vijay

doi:10.1016/j.cegh.2021.100705

Cited by 7 publications

(20 citation statements)

References 18 publications

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“…The comorbidities in this study were cardiovascular disease, diabetes, and hypertension, respectively, agreeing with the findings of other studies [ 23 , 26 – 29 ]. Some studies reported that the prevalence of chronic kidney disease was higher among patients with GI symptoms [ 30 , 31 ].…”

Section: Discussionsupporting

confidence: 93%

Gastrointestinal symptoms are associated with a lower risk of hospitalization and mortality and outcomes in COVID-19

et al. 2022

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Background We aimed to find the association between gastrointestinal (GI) and respiratory symptoms with mortality and hospitalization among COVID-19 patients. Methods We analyzed the registered data of COVID-19 patients from February 20, 2020, to March 10, 2021. Depending on the patients’ disease symptoms, four categories were defined: patients with only GI symptoms, patients with only respiratory symptoms, patients with both symptoms, and patients with other symptoms. Logistic regression analysis was used to assess the association of groups with outcomes. Results A total of 42,964 patients from 23 hospitals were included, of which 26.5% patients had at least one or more GI symptoms. Of total patients, 51.58% patients were hospitalized among which 22.8% had at least one or more GI symptoms. GI symptoms significantly decreased the odds of mortality (OR 0.72, 95% CI 0.56–0.92), but respiratory symptoms increased the odds for mortality (1.36: 1.24–1.50), compared with patients with other symptoms. Moreover, the odds ratio of patients who had both respiratory and GI symptoms increased (1.52: 1.31–1.78) compared with patients with other symptoms. The same results were observed for hospitalization as the outcome. Conclusions Our study showed that the presence of GI symptoms in COVID-19 at the time of admission was associated with a lower odds of hospitalization and mortality; however, this association had higher odds for respiratory symptoms.

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Section: Discussionsupporting

confidence: 93%

Gastrointestinal symptoms are associated with a lower risk of hospitalization and mortality and outcomes in COVID-19

et al. 2022

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“…This might be one of the reasons for increased risk of mortality among the COVID-19 patients. The probability of survival was more than 80% if the patients got admitted within a week as compared to delayed admission, and this was in concordance with the findings by Priya S[ 7 ] who reported that it was more than 90% within 1 week and 80% between 7 and 10 days from the symptom onset to admission and gradually declined thereafter.…”

Section: Discussionsupporting

confidence: 90%

“…In our study, the majority of the deaths (53%) occurred in the older age group of more than 60 years, which was similar to findings by Priya S et al . [ 7 ] in which 59% of deaths occurred in the older age group and various studies[ 5 24 25 26 27 28 ] across the globe. Age-related factors such as declining immune functions, variations in quality and quantity of mucins and glycoproteins on the mucosal barriers and a gradual decline in clearing the inhaled particles could be attributed to increased risk of mortality among the elderly population.…”

Section: Discussionmentioning

confidence: 99%

“…In India, situation is even different among the states with regard to the presentation of COVID-19. [ 5 6 7 ] One-third of the COVID-19 infections usually are asymptomatic and recover without any complications. [ 8 ] The majority of the mild or moderate cases present with features like fever, cough, breathlessness, myalgia, fatigue, pneumonia and anosmia.…”

Section: Introductionmentioning

confidence: 99%

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Clinicoepidemiological profile of COVID-19 patients admitted at a teaching institute in a hilly area of India during the second wave—A retrospective observational study

Udayar

Marella

Naidu

et al. 2022

Journal of Family Medicine and Primary Care

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Introduction: COVID-19 ongoing pandemic has resulted in millions of deaths globally, and India has recorded the second highest number of confirmed cases till now. In the absence of effective treatment, it becomes crucial to know about the course of the disease in hospital settings for effective patient care. The present study discusses the clinicoepidemiological, haematological and biochemical determinants among survivors and non-survivors of COVID-19 patients admitted to a tertiary care hospital in a hilly area. Methods: A record-based cross-sectional study was carried out at the government hospital from March 2021 to June 2021, which included all confirmed cases of 18 years and above. Demographic details, delayed admission, co-morbidities and laboratory parameters were collected. Results: Out of a total of 1267 COVID-19 patients, the mean age of survived and succumbed was 50.77 ± 16.1 and 60.50 ± 14.2 years, respectively ( P < 0.001). The mean survival time in males (17.7 days) was lesser compared to that in females (20.3 days). Two hundred and twelve of them practised self-medication. The mean duration of delayed testing (2.95 ± 2.3 vs 3.36 ± 2.2 days), mean values of haemoglobin (11.39 ± 2.1 vs 12.5 ± 1.7), platelet count (193.8 ± 94.6 vs 253.1 ± 105.9), leucocyte count (11.53 ± 5.72 vs 9.11 ± 5.21), neutrophil–lymphocyte ratio (10.0 ± 2.9 vs 7.3 ± 3.5), urea (61.16 ± 51.8 vs 30.2 ± 21.2) and creatinine (2.13 ± 2.9 vs. 1.1 ± 0.3) among the two groups were statistically significant ( P < 0.001). Increasing age, contact history, hypertension [OR 3.2 (95% CI, 1.40–7.39)], diabetes [OR 1.9 (95% CI, 0.81–4.40)] and chronic kidney disease [OR 15.4 (95% CI, 5.23–45.71)] were found to be associated with increased risk of mortality ( P < 0.005). Conclusions: Public health interventions like contact tracing, testing and early identification of laboratory parameters and treatment on priority would help in providing effective care so that the mortality can be reduced.

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“…The results of subgroup analysis can be attributed to the predisposition of the disease in men, in which some studies reported that severe morbidity and mortality are more common in the male sex [22,23] . The more viral load and more severe disease may explain the higher AL, ACD and CCT measurements in men.…”

Section: Discussionmentioning

confidence: 99%

The Optical Biometric Measurements In Patients With Previously Received Covid-19 Treatment

Çetinkaya

Kurt

2021

Preprint

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Purpose: To determine the comparison of the optical biometric measurements using optical biometry in patients with previously received COVID-19 treatment and the control group.Methods: In this cross-sectional study, the COVID-19 was diagnosed by polymerase chain reaction test, clinical signs and radiologic findings. Patients with previously received COVID-19 treatment was determined as COVID-19 group and the age and sex-matched healthy subjects were served as control group. The optical biometric measurements including corneal astigmatism, keratometry, astigmatic axis, central corneal thickness, anterior chamber depth and axial length were obtained using Nidek optical biometry (AL-Scan; Nidek Co., Ltd., Japan).Results: The measurements of keratometry(p=0,47), corneal astigmatism(p=0,42), axial length(p=0,78), anterior chamber depth(p=0,46) and central corneal thickness(p=0,43) were similar between the COVID-19 and control groups. The astigmatic axis type taken from 2.4 mm of the cornea showed statistically significant difference between two groups (p=0,01), while the measurements taken from 3 mm of the cornea were similar(p=0,15). In the subgroup analysis, axial lenght, anterior chamber depth and central corneal thickness measurements were found statistically significantly higher in the male gender of the COVID-19 group (p= 0,03; p= 0,01; p=0,03, Mann Whitney U).Conclusion: Changing in the optical biometric measurements can be seen as a result of the fact that COVID-19 is more frequent and severe in male gender and SARS-CoV-2 can attach to the cornea via ACE-2 receptors. To our knowledge, there is no study about this subject yet and conducting research with other studies on this issue will provide a better enlightenment about this subject.

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“Factors influencing the outcome of COVID-19 patients admitted in a tertiary care hospital, Madurai.- a cross-sectional study”

Cited by 7 publications

References 18 publications

Gastrointestinal symptoms are associated with a lower risk of hospitalization and mortality and outcomes in COVID-19

Gastrointestinal symptoms are associated with a lower risk of hospitalization and mortality and outcomes in COVID-19

Clinicoepidemiological profile of COVID-19 patients admitted at a teaching institute in a hilly area of India during the second wave—A retrospective observational study

The Optical Biometric Measurements In Patients With Previously Received Covid-19 Treatment

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