The present research aimed to evaluate the position of health and safety system in multi-level strategic management of Shiraz University of medical science. This is a co relational-surveying study. Field information was collected via questionnaire. Statistical population consists of all staffs of Shiraz University of medical science (900 individuals). To determine the sample size, Morgan Table was used so 269 individuals were selected by simple random method. To prevent drop out, 320 questionnaires were distributed and collected. As a result, 308 questionnaires were completed. Random sampling was used in the research. The instrument includes researcher-conducted questionnaire for evaluation of position of health and safety in multilevel management. The questionnaire's validity and reliability were confirmed. To analyze data, Kolmogorov-Smirnov, Pearson correlation coefficient, one sample T, independent T as well as variance analysis tests and SPSS version 20 were used. Results indicated that the safety system has an improper position in multilevel management of staffs in Shiraz University of medical science in addition; health system has a good position in multilevel management of staffs in Shiraz University of medical science. It is suggested that subjects' related to multilevel management of staffs is considered.