Factors influencing the risk of abnormal pregnancy outcome in epileptic women: A multi-centre prospective study

Steegers‐Theunissen, R.P.M.; Renier, W.O.; Borm, George F.; Thomas, Chris M.G.; Merkus, Hans M.W.M.; Coul, Dolf A. W. Op De; Jong, P.A. de; Geijn, H.P. van; Wouters, M.G.A.J.; Eskes, T.K.A.B.

doi:10.1016/0920-1211(94)90046-9

Cited by 70 publications

(33 citation statements)

References 16 publications

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“…Folic acid deficiency has been postulated as a possible cofactor in the teratogenic effects associated with the maternal use of AEDs during pregnancy [13,18,31,33].…”

Section: Discussionmentioning

confidence: 99%

Spontaneous abortion and the prophylactic effect of folic acid supplementation in epileptic women undergoing antiepileptic therapy

et al. 2008

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“…Folic acid deficiency has been postulated as a possible cofactor in the teratogenic effects associated with the maternal use of AEDs during pregnancy [13,18,31,33].…”

Section: Discussionmentioning

confidence: 99%

Spontaneous abortion and the prophylactic effect of folic acid supplementation in epileptic women undergoing antiepileptic therapy

et al. 2008

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“…None of the women were under treatment for any infectious, endocrine, metabolic or malignant disease. Part of this cohort of women has been described in detail previously (Steegers-Theunissen et al, 1994;Cikot et al, 2001). The study by Steegers-Theunissen et al excluded the 15 women who previously delivered a child with a neural tube defect and Cikot et al included only 102 nulliparous control women with an uneventful, singleton pregnancy and normal outcome.…”

Section: Methodsmentioning

confidence: 99%

Maternal periconceptional biochemical and hematological parameters, vitamin profiles and pregnancy outcome

et al. 2003

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Objectives: To evaluate periconceptional maternal biochemical and hematological parameters and vitamin profiles in relation to the risk of early pregnancy loss and birth weight. Design: Prospective longitudinal study. Setting: University Medical Centre Nijmegen, Academic Medical Centre, Amsterdam, Maria and Elisabeth Hospitals, Tilburg, and Catharina Hospital, Eindhoven, The Netherlands. Subjects: A cohort of 240 women recruited before pregnancy. Interventions: Blood samples were taken preconceptional and at 6 and 10 weeks amenorrhea in which the concentrations of hemoglobin, hematocrit, creatinin, uric acid, total protein, serum iron, total iron-binding capacity, ferritin, and the concentrations of retinol, tocopherol, thiamine, riboflavin, pyridoxal-5 0 -phosphate, cobalamin and folate were analyzed. Main outcome measures: Risk of early pregnancy loss and birth weight. Results: The risk of early pregnancy loss increased with increasing prepregnancy weight, and when the periconceptional decline in hematocrit, creatinin and uric acid was less profound (slope: Po0.01). Maternal smoking was negatively associated with birth weight (mean reduction of 183 g, Po0.05). Maternal age and prepregnancy weight were positively associated with birth weight (Po0.01). No significant associations were found between vitamin concentrations and risk of early pregnancy loss or birth weight. Conclusions: Several periconceptional biochemical parameters are significantly associated with early pregnancy loss. The effects of maternal periconceptional health on embryonic development and subsequent pregnancy outcome should be further explored.

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“…Various degrees of prenatal and postnatal growth retardation were described and attributed to maternal AED use. A number of studies showed various degrees of growth impairment, either on all growth parameters, and/or lower Apgar scores [28, 32, 38, 39], or only on one of these parameters [30, 34, 36]. Some studies showed growth impairment to be associated with specific AEDs, such as valproate [25, 33, 41], carbamazepine [27]and phenobarbital [35, 41].…”

Section: Teratogenic Effects Of Aedsmentioning

confidence: 99%

“…Several studies evaluated the association of AEDs with growth impairment or adverse perinatal outcome [22, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40]. The most frequent outcome parameters were birth weight, length, head circumference at birth, placental weight and perinatal status of the child as assessed by the Apgar score.…”

Section: Teratogenic Effects Of Aedsmentioning

confidence: 99%

Antiepileptic Drugs in Pregnancy: Options for the Prevention of Congenital Abnormalities

Berg¹,

Lindhout²

2002

Public Health Genomics

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Factors influencing the risk of abnormal pregnancy outcome in epileptic women: A multi-centre prospective study

Cited by 70 publications

References 16 publications

Spontaneous abortion and the prophylactic effect of folic acid supplementation in epileptic women undergoing antiepileptic therapy

Spontaneous abortion and the prophylactic effect of folic acid supplementation in epileptic women undergoing antiepileptic therapy

Maternal periconceptional biochemical and hematological parameters, vitamin profiles and pregnancy outcome

Antiepileptic Drugs in Pregnancy: Options for the Prevention of Congenital Abnormalities

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