Factors influencing the Sharp score of 1057 patients with rheumatoid arthritis and anemia: a retrospective study

Abstract

Objective This study examined the relationship of the Sharp score with demographic factors and clinical immune-inflammatory markers in patients with anemia in rheumatoid arthritis (RA). Methods The clinical data of 1057 patients with RA and anemia and 1006 patients with RA without anemia were retrospectively analyzed. Spearman’s correlation coefficient analysis, association rule analysis, and logistic regression were used to study the relationships between the Sharp score and influencing factors in patients with RA and anemia. Results The incidence of anemia was 51.24% (1057/2063), and mild anemia accounted for 81.93% (866/1057) of cases. Spearman’s correlation coefficient and association rule analyses revealed that the Sharp score of patients with RA and anemia was correlated with immune-inflammatory response and anemia. Logistic regression analysis illustrated that advanced age (>60 years), female, low serum iron levels, C-reactive protein positivity, and immunoglobulin A positivity were risk factors for a high Sharp score (>28.25) in patients with RA and anemia. Conclusion The Sharp score is closely related to clinical disease activity and anemia, and it should be considered in the treatment strategy of patients with RA and anemia.

Genetic Associations Between Autoimmune Diseases and Anemia: A Mendelian Randomization Analysis to Inform Clinical Practice.

“…A retrospective examination spanning two decades revealed that as many as 29.4% of 34 neonatal lupus erythematosus cases were accompanied by anemia 41 . Similarly, another retrospective investigation ascertained that the anemia incidence rate soared to 51.24% among 1057 patients a icted with rheumatoid arthritis 42 .…”

Anemia in elderly rheumatoid arthritis patients: a cohort study

“…It has been reported that the prevalence of anemia in RA is related to the prognosis of patients. For the parameters to be evaluated, including swelling, joint pain and activity level, there is a positive correlation between the improvement of symptoms and the relief of anemia [ 15 , 16 ]. Previous studies [ 17 , 18 ] have shown that the quality of life score of RA patients is significantly improved after anemia treatment, RA patients with anemia may have more severe joint disease, and if anemia is successfully treated, joint disease may also be improved.…”

Risk Factors Analysis for the Development of Hypocomplementemia in Rheumatoid Arthritis Patients: A Single-Center Retrospective Study

“…Anemia is a relatively common clinical expression of RA, influencing 30–70% of patients. 23 Anemia is closely related to the disease activity of RA and can be served as predicting incipient joint damage of RA. 24 The level of Hb104.50 (89.75–119.50)g/L in RA with HC group was lower than the level of Hb110.00 (98.00–121.00)g/L in RA without HC group, and anemia was more serious, which suggested that HC might correlate with disease activity of RA.…”