Factors Influencing the Visual Acuity of Chronic Central Serous Chorioretinopathy

Kim, Yun Young; Flaxel, Christina J.

doi:10.3341/kjo.2011.25.2.90

Cited by 29 publications

(19 citation statements)

References 37 publications

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“…Chronic CSCR was defined as the duration of decreased visual acuity, residual symptoms, and RPE changes persisting for at least 6 months [10]. Chronic cases were then divided into the following two subgroups: chronic active CSCR, which was defined as cases with apparent neurosensory retinal detachment, and chronic nonactive CSCR or sequelae of CSCR, defined as cases with no neurosensory detachment [11] (Fig. 2).…”

Section: Methodsmentioning

confidence: 99%

Macular ganglion cell complex thickness in acute and chronic central serous chorioretinopathy

et al. 2016

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Central serous chorioretinopathy (CSCR) is characterized by neurosensory retinal detachment. Because the retina pigment epithelium and choroidal pathology is the current mechanism in CSCR, many studies in the literature focused on the outer retinal layers. There is little information about the functional or histological structure of the detached retina. In this study, we assess the ganglion cell complex (GCC) thickness using optical coherence tomography (OCT) in patients with acute and chronic CSCR. The medical records of 16 acute and 19 chronic CSCR patients which have no other disorders that cause a serous macula detachment were analyzed. Chronic cases were also divided into two subgroups: chronic active and chronic nonactive CSCR. The eyes with extramacular involvement or cystoid degeneration and cases which developed choroidal neovascularization were excluded from the study. The mean, minimum, superior-nasal, superior, superior-temporal, inferior-nasal, inferior, and inferior-temporal GCC values obtained using OCT were used for analysis. The duration from the onset was 7.8 ± 4.5 weeks and the mean age was 45.0 ± 10.7 years in acute CSCR, and in chronic cases the values were 36.0 ± 6.2 weeks and 52.9 ± 10.5 years, respectively. There were no significant differences in sex distribution. The chronic cases were statistically significantly older than acute cases (p = 0.02). While there was no difference between the acute and chronic cases, there were statistically significant differences between the chronic CSCR and control group in all values of GCC. Additionally, there were statistically significant differences between the acute CSCR and control group in mean, minimum, and superior-temporal GCC thicknesses. Although choroid and outer retinal layers play an important role in the pathogenesis of CSCR, there is scant information about the functional or histological structure of the detached retina in CSCR. Our results showed that GCC was significantly reduced in both acute and chronic CSCR compared to healthy subjects. Analysis of ganglion cell helps us understand the etiology of the patients which healed anatomically but had limited visual improvement in CSCR.

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Section: Methodsmentioning

confidence: 99%

Macular ganglion cell complex thickness in acute and chronic central serous chorioretinopathy

et al. 2016

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“…Moon et al [26] demonstrated that one of the factors limiting visual improvement after PDT for CSC was foveal IS/OS damage. Kim et al [27] documented that preserved outer photoreceptor layer and continuity of IS/OS line were correlated with better final BCVA. Ooto et al [28] also showed that visual loss was associated with abnormal cone mosaic patterns and reduced cone densities in eyes with resolved CSC.…”

Section: Discussionmentioning

confidence: 99%

Long-term chorioretinal changes after photodynamic therapy for chronic central serous chorioretinopathy

Vasconcelos

Marques

Santos

et al. 2013

Graefes Arch Clin Exp Ophthalmol

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Purpose To evaluate morphological and functional chorioretinal changes 5 years after standard photodynamic therapy (PDT) for chronic central serous chorioretinopathy (CSC). Methods A retrospective, nonrandomized study, including patients with chronic CSC treated with standard PDT and followed for at least 60 months. All patients underwent a complete ophthalmological examination, and the location and number of treatments were registered. Five or more years after treatment, subfoveal and non-subfoveal treated areas were evaluated with Spectralis optical coherence tomography and microperimetry. Results Seventeen eyes of 15 patients were included, with mean age of 48.3±8.4 years and a mean follow-up of 80.6± 12.4 months (range from 62 to 104 months). All eyes had neurosensory detachment (NSD) at baseline. Treatment was performed under the fovea in 58.8 % and in a non-foveal area in 41.2 % of the eyes. At the final visit all eyes had resolution of the NSD, with a statistical significant reduction in central macular thickness (p=0.005) and preserved neuroretinal thickness (p=0.839). There was a statistical difference between initial and final BCVA (p<0.001) and a mean gain of 8.4±7.8 letters. Subfoveal morphological changes in external limiting membrane (ELM) and in photoreceptor inner and outer segment junction (IS/OS) were correlated with final BCVA (p=0.015 and p=0.014 respectively), but not with the variation of BCVA. There was a statistical correlation between morphological changes in IS/OS line and retinal sensitivity in the central 12°and 2°(p=0.003 and p=0.002 respectively). The morphological changes in the subfoveal layers were not dependent on treatment location (p=0.154, p=0.644, and p=1.0 for ELM, IS/OS line, and retinal pigment epithelium respectively). Subfoveal final mean choroidal thickness was 295.1±68.7 μm, and showed no statistical difference from the normal population (p=0.633). Conclusions Morphological and functional chorioretinal changes, observed 5 or more years after standard PDT for chronic CSC, were not correlated with the location of treatment, neither with the progression of visual acuity or with the location of treatment, and are more likely to be related to the disease itself than with the treatment provided.

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“…Optical coherence tomography can also offer valuable prognostic information, as it can demonstrate cystoid degeneration, disruption of the outer photoreceptors and inner/outer segment junction, which are associated with poor visual outcome. [10] Hence optical coherence tomography can be used as a complimentary diagnostic tool for evaluation of patients of central serous chorioretinopathy and can be used as a primary diagnostic procedure for patients in whom fundus fluorescein angiography is contraindicated CONCLUSION: Optical coherence tomography is a safe diagnostic tool with no side effects and can be used as a complimentary investigative procedure to diagnose, access progression and response to treatment in case of central serous retinopathy. It can also be used as a primary diagnostic procedure when central serous chorioretinopathy is suspected in pregnant women and patients in whom fundus fluorescein angiography is contraindicated.…”

Section: Discussionmentioning

confidence: 99%

Role of Optical Coherence Tomography in Central Serous Chorioretinopathy

Wani¹,

Bhat²,

Ahangar³

et al. 2015

jemds

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PURPOSE:To study the role of optical coherence tomography in central serous chorioretinopathy. MATERIAL AND METHODS: A total of 48 eyes of 48 patients with a clinical diagnosis of central serous chorioretinopathy were evaluated with spectral domain optical coherence tomography. After detailed ocular examination, followed by fundus fluorescein angiography, optical coherence tomography was performed and various anatomic features were noted. RESULTS: Out of 48 eyes, 41 had acute and 7 had chronic central serous chorioretinopathy. The mean age of the patients was 35 (SD7.1) years with male (83.4%) preponderance in our study. All patients had unilateral involvement with blurring of vision (43.75%) and metamorphopsia (31.25%) being the main presenting complaints. Fundus fluorescein angiography revealed a total of 56 leakage points with ink-blot pattern being 6 times more frequent than smoke-stack pattern in our study. On optical coherence tomography neurosensory detachment was seen in 44 eyes. Total macular thickness ranged from 220µm-1120µm (mean±SD:447±219) and vault height ranged from 100µm-900µm (mean±SD:350±187). Retinal pigment epithelial abnormality was seen in 87.5% eyes, retinal pigment epithelial detachment in 18.75% eyes and retinal pigment epithelial bulge in 27.09% patients. CONCLUSION: Optical coherence tomography can be used as a complimentary diagnostic tool in central serous chorioretinopathy.

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Factors Influencing the Visual Acuity of Chronic Central Serous Chorioretinopathy

Cited by 29 publications

References 37 publications

Macular ganglion cell complex thickness in acute and chronic central serous chorioretinopathy

Macular ganglion cell complex thickness in acute and chronic central serous chorioretinopathy

Long-term chorioretinal changes after photodynamic therapy for chronic central serous chorioretinopathy

Role of Optical Coherence Tomography in Central Serous Chorioretinopathy

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