Factors influencing waist/hip ratio in randomly selected pre- and post-menopausal women in the DOM-project (preliminary results)

Tonkelaar, I. den; Seidell, Jacob C.; Noord, P.A.H. van; Halewijn, E.A. Baanders-van; Jacobus, J. H.; Bruning, P.F.

doi:10.1016/0378-5122(91)90291-w

Cited by 19 publications

(28 citation statements)

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“…1,2 E 2 replacement therapy can normalize these abnormalities by reducing food intake and increasing metabolic expenditure. 1,2 This anorexigenic role of E 2 has also been shown in rodent studies. [3][4][5] Ovariectomized rats display increase in food intake and adipose tissue deposition, which can be readily reversed with the re-introduction of E 2 .…”

Section: Introductionmentioning

confidence: 79%

Estrogen inhibits NPY secretion through membrane-associated estrogen receptor (ER)-α in clonal, immortalized hypothalamic neurons

Dhillon

Belsham

2010

Int J Obes

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Objective: Estrogen (E 2 ) has an inhibitory effect on food intake by acting centrally in the hypothalamus, although it is not clear which hypothalamic neurons are involved in this process. Earlier studies from our lab and others have implicated neuropeptide Y (NPY) as an important central anorexigenic target of E 2 . This study was designed to investigate whether E 2 can directly regulate NPY secretion and examine the cellular mechanisms and receptors responsible for this anorexigenic action of E 2 . Design: Clonal, murine, hypothalamic neuronal cell models, mHypoE-42 and mHypoA-2/12, were investigated for NPY secretory responses to 17b-estradiol (E 2 ) in the presence or absence of pharmacological inhibitors directed against the phosphatidylinositol-3-kinase (PI3K), mitogen-activated protein kinase (MAPK) and AMP-activated kinase (AMPK) pathways or to estrogen receptor (ER) specific agonists/antagonists. Measurements: The presence of hypothalamic markers and characterization of neuronal cell lines was completed with polymerase chain reaction. NPY levels were measured using an enzyme immunoassay (EIA). The expression of ER-a and caveolin-1 was analyzed using immunocytochemistry. Results: E 2 significantly decreased NPY secretion in both the mHypoE-42 and mHypoA-2/12 neurons. The E 2 -mediated repression of NPY secretion in the mHypoE-42 and mHypoA-2/12 neurons required ER-a, but not ER-b, as shown by studies using an ER-specific agonist/antagonists. Additionally, using immunocytochemistry we detected colocalization of ER-a and the membrane-associated signaling protein caveolin-1. Importantly, using E 2 -conjugated bovine serum albumin (E 2 -BSA) and ER antagonists, we were able to show that the E 2 -mediated decrease in NPY secretion occurred through membrane-bound ER-a. Finally, using a combination of pharmacological inhibitors, we found that inhibition of the PI3K or AMPK pathway blocked the E 2 -mediated decrease in NPY secretion. Conclusion: These findings indicate that the central anorexigenic action of E 2 occurs at least partially through hypothalamic NPY-synthesizing neurons. This regulation of NPY secretion occurs through rapid signaling mechanisms through membrane bound ER-a.

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Section: Introductionmentioning

confidence: 79%

Estrogen inhibits NPY secretion through membrane-associated estrogen receptor (ER)-α in clonal, immortalized hypothalamic neurons

Dhillon

Belsham

2010

Int J Obes

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“…Several studies have documented age-related changes in adipose tissue distribution as reflected by an increase in the WHR (293,569). In a sample of 52,953 women, the body weight increase observed with age was more likely to accumulate in the abdominal area than in the gluteofemoral area (293).…”

Section: A Agementioning

confidence: 99%

Pathophysiology of Human Visceral Obesity: An Update

Tchernof

Després

2013

Physiological Reviews

1,977

1,613

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LTchernof A, Després J-P. Pathophysiology of Human Visceral Obesity: An Update. Physiol Rev 93: 359 -404, 2013; doi:10.1152/physrev.00033.2011.-Excess intra-abdominal adipose tissue accumulation, often termed visceral obesity, is part of a phenotype including dysfunctional subcutaneous adipose tissue expansion and ectopic triglyceride storage closely related to clustering cardiometabolic risk factors. Hypertriglyceridemia; increased free fatty acid availability; adipose tissue release of proinflammatory cytokines; liver insulin resistance and inflammation; increased liver VLDL synthesis and secretion; reduced clearance of triglyceride-rich lipoproteins; presence of small, dense LDL particles; and reduced HDL cholesterol levels are among the many metabolic alterations closely related to this condition. Age, gender, genetics, and ethnicity are broad etiological factors contributing to variation in visceral adipose tissue accumulation. Specific mechanisms responsible for proportionally increased visceral fat storage when facing positive energy balance and weight gain may involve sex hormones, local cortisol production in abdominal adipose tissues, endocannabinoids, growth hormone, and dietary fructose. Physiological characteristics of abdominal adipose tissues such as adipocyte size and number, lipolytic responsiveness, lipid storage capacity, and inflammatory cytokine production are significant correlates and even possible determinants of the increased cardiometabolic risk associated with visceral obesity. Thiazolidinediones, estrogen replacement in postmenopausal women, and testosterone replacement in androgen-deficient men have been shown to favorably modulate body fat distribution and cardiometabolic risk to various degrees. However, some of these therapies must now be considered in the context of their serious side effects. Lifestyle interventions leading to weight loss generally induce preferential mobilization of visceral fat. In clinical practice, measuring waist circumference in addition to the body mass index could be helpful for the identification and management of a subgroup of overweight or obese patients at high cardiometabolic risk.

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“…Ageindependent associations between menopausal status and BMI were found in several studies. 32,35 These reports found that BMI was higher in postmenopausal women after statistically adjusting for age. 35 It has been proposed that women who became postmenopausal had reductions in resting metabolic rate than women who remained premenopausal.…”

Section: Kalita N Et Al Int J Res Med Sci 2017 May;5(5):1953-1958mentioning

confidence: 94%

“…32,35 These reports found that BMI was higher in postmenopausal women after statistically adjusting for age. 35 It has been proposed that women who became postmenopausal had reductions in resting metabolic rate than women who remained premenopausal. These decreases in energy expenditure with no change or increases in energy intake will place women in positive energy balance, which will increase total fatness and possibly central adiposity.…”

Section: Kalita N Et Al Int J Res Med Sci 2017 May;5(5):1953-1958mentioning

confidence: 94%

“…Significant differences in BMI were noted between premenopausal and postmenopausal women in several studies. 32,35,36 The average differences in BMI between premenopausal and postmenopausal women are often small, thus making large samples necessary to detect these small differences. Because differences in BMI in these studies were found before adjustment for age, it is unclear whether these changes are independent of the aging process.…”

Section: Kalita N Et Al Int J Res Med Sci 2017 May;5(5):1953-1958mentioning

confidence: 99%

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A cross sectional study evaluating the association of serum calcium, serum magnesium, and body mass index in premenopausal and postmenopausal women

Kalita

Choudhury

2017

Int J Res Med Sci

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Background: To determine serum calcium, serum magnesium, and BMI (body mass index) in premenopausal and postmenopausal women, and find out any changes in these after menopause, and the independent association of serum calcium, serum magnesium with BMI in pre and post-menopausal women , if any.Methods: 100 adult women attending Gauhati medical college outdoor clinics were included in the study. Patients with medical history of major systemic diseases, women on hormone replacement therapy, and women who had surgical menopause were not included in the study. Estimation of serum calcium and serum magnesium from cubital venous blood was done by photocolorimetry method. For statistical analysis the value of laboratory parameters were presented as the Mean±SD (standard deviation). A Student’s unpaired t-test was used for cross-sectional comparisons of continuous variables between the groups.Results: The mean serum calcium and also the mean serum magnesium levels were lower in the postmenopausal group and was statistically significant. Though the mean BMI in the postmenopausal group was higher than the premenopausal group, it was found to be statistically not significant.Conclusions: The postmenopausal subjects had lower mean values of serum calcium and serum magnesium, but within the normal serum reference values.

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Factors influencing waist/hip ratio in randomly selected pre- and post-menopausal women in the DOM-project (preliminary results)

Cited by 19 publications

References 0 publications

Estrogen inhibits NPY secretion through membrane-associated estrogen receptor (ER)-α in clonal, immortalized hypothalamic neurons

Estrogen inhibits NPY secretion through membrane-associated estrogen receptor (ER)-α in clonal, immortalized hypothalamic neurons

Pathophysiology of Human Visceral Obesity: An Update

A cross sectional study evaluating the association of serum calcium, serum magnesium, and body mass index in premenopausal and postmenopausal women

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