Factors involved in the decision to decline prenatal screening with noninvasive prenatal testing (NIPT)

Abstract

Objective: To investigate factors involved in the decision to decline prenatal screening with noninvasive prenatal testing (NIPT).Method: A questionnaire study was conducted among 219 pregnant women in the Netherlands who had declined prenatal screening with NIPT (TRIDENT-2 study).Respondents were selectively recruited from three hospitals and 19 midwifery practices, primarily located in or near socioeconomically disadvantaged neighborhoods. 44.3% of the respondents were of non-Western ethnic origin and 64.4% were religious.Results: Most respondents (77.2%) found the decision to decline NIPT easy to make, and 59.8% had already made the decision before information about NIPT was offered.These respondents were more often religious, multigravida, and had adequate health literacy. The main reasons to decline NIPT were "I would never terminate my Lisanne van Prooyen Schuurman and Karuna van der Meij contributed equally to this work.

Preconception education program for non-invasive prenatal testing focused on interest in genetics among female university students in Japan: a quasi-experimental study comparing pre-intervention, post-intervention, and three-month follow-up results

“…However, such changes can be considered a fundamental and essential process for clarifying their personal values and improving decisionmaking [56,57] on NIPT. While decision-making on NIPT was reportedly affected by healthcare providers' explanations [2][3][4]58], social pressure [59], and the opinions of family members [60], a study showed that the majority of pregnant women who decided against NIPT had made the decisions before pre-test counseling based on their personal values [61]. This indicates that clarifying personal values is necessary for women to make decisions on NIPT.…”

Highlights of the 26th ISPD annual conference, hosted in a vibrant Canadian city along with the Montreal grand prix 2022

“…In Montreal, we heard the pros and cons of offering NIPT for aneuploidy to all women or just for those at high risk, 5 but we also heard how it may be useful for identifying maternal viral infections 6 . One of the submitted abstracts described the factors influencing uptake of NIPT and noted that it is not only personal values and beliefs influencing choice but also out‐of‐pocket costs of NIPT that hinder equal access to this technology 7 . A further paper, presented as a poster in Montreal, describes the potential application of droplet digital PCR for noninvasive prenatal diagnosis of monogenic conditions 8 .…”

“…6 One of the submitted abstracts described the factors influencing uptake of NIPT and noted that it is not only personal values and beliefs influencing choice but also out-of-pocket costs of NIPT that hinder equal access to this technology. 7 A further paper, presented as a poster in Montreal, describes the potential application of droplet digital PCR for noninvasive prenatal diagnosis of monogenic conditions. 8 Other key highlights of the meeting included carrier screening, now being widely adopted in the USA but less so in other parts of the world.…”