Factors involved in the resilience of incidence and decrease of mortality from scorpion stings in Mexico

Chippaux, Jean-Philippe; Alfredo, Celis; Boyer, Leslie V.; Alagón, Alejandro

doi:10.1016/j.toxicon.2020.10.011

Cited by 10 publications

(7 citation statements)

References 32 publications

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“…As such, severe stings require prompt treatment with specific antivenoms and intensive cardiorespiratory support [1]. In the Americas, Mexico has the highest scorpion envenomation incidence [2], followed by the Amazon region where the rate has been estimated to range between 30 and 200 cases per 100,000 inhabitants [3]. These numbers are most probably an underestimation as large sections of Amazonia remain epidemiologically underreported, with the number of cases to be much higher in remote riverine and indigenous communities [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Amazonian scorpions and scorpionism: integrating toxinological, clinical, and phylogenetic data to combat a human health crisis in the world’s most diverse rainfores

Borges

Graham

Cândido

et al. 2021

J. Venom. Anim. Toxins incl. Trop. Dis

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Venom from Amazonian scorpions of the genus Tityus contains components capable of eliciting a distinct clinical, mostly neurological, syndrome. This contrasts with the mainly autonomic manifestations produced after envenomation by congeneric southern and northern South American species. Herein, we summarize Pan-Amazonian scorpionism by synthesizing available toxinological, clinical, and molecular data gathered from all affected areas in Amazonia, including Brazil, Ecuador, Colombia, Peru, Venezuela, and French Guiana. We searched multiple databases, as well as our own records, for reports of scorpion envenomations in Amazonia by confirmed Tityus spp., and compared the clinical manifestations. To help uncover clinical and venom relationships among problematic species, we explored phylogenetic relationships with a rate-calibrated analysis of mitochondrial COI data from available species. The possible existence of diversity gradients for venom toxic and immunogenic components despite the predicted strong phylogenetic association among species is underscored by discussed clinical and toxinological findings. A multicentric effort, involving all nations affected by this neglected disease, is urgently needed to offer alternatives for treating and understanding this pathology, including the preparation of neutralizing antibodies with a broad range of efficacy.

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Section: Introductionmentioning

confidence: 99%

Amazonian scorpions and scorpionism: integrating toxinological, clinical, and phylogenetic data to combat a human health crisis in the world’s most diverse rainfores

Borges

Graham

Cândido

et al. 2021

J. Venom. Anim. Toxins incl. Trop. Dis

View full text Add to dashboard Cite

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“…Most of the time, the rehabilitation cost must be assumed by the patient itself, who usually does not have the resources to do so. The family economy in areas with a high rate of snakebites is categorized as impoverished rural areas 12,111 .…”

Section: Clinical Findings Social and Economic Impact Of Snakebite En...mentioning

confidence: 99%

“…Snakebites envenomation is found in Latin America, Africa, Asia and Oceania, poor rural tropics populations [8][9][10][11] . These countries have an absence of public health policies 12 pointed to snakebites diseases, so; they have no access to health services 1,13 and have a shortage of both medical supplies and trained human medical equipment.…”

Section: Introductionmentioning

confidence: 99%

“…More than 4 000 snake species worldwide, but only 250 are known of medical relevance 2 . Regions with the most incredible diversity of venomous snakes include Latin America and Asia 12 . Snakebite should be considered an NTD priority because it involves a wide snake diversity of species and, thus, a variety of toxins 14 .…”

Section: Introductionmentioning

confidence: 99%

“…Generally, global data for snakebites are not accurate, showing variability mainly due to scarce and not representative epidemiological studies 5,19,21 . Most hospital reports 22 and surveys 12 do not report important data such as incidence, mortality, and physical and psychological consequences suffered by patients 23 . According to Pach et al 21 , five million snakebites are reported annually worldwide, two to three million results in poisonings and 80 000 to 130 000 people die from these diseases.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Current situation of snakebites envenomation in the Neotropics: Biotechnology, a versatile tool in the production of antivenoms.

Romo

Arias

Martin-Solano

2022

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Snakebite envenomation is a neglected tropical disease that affects millions of people around the world with a great impact on health and the economy. Unfortunately, public health programs do not include this kind of disease as a priority in their social programs. Cases of snakebite envenomations in the Neotropics are inaccurate due to inadequate disease management from medical records to the choice of treatments. Victims of snakebite envenomation are primarily found in impoverished agricultural areas where remote conditions limit the availability of antivenom. Antivenom serum is the only Food and Drug Administration-approved treatment used up to date. However, it has several disadvantages in terms of safety and effectiveness. This review provides a comprehensive insight dealing with the current epidemiological status of snakebites in the Neotropics and technologies employed in antivenom production. Also, modern biotechnological tools such as transcriptomic, proteomic, immunogenic, high-density peptide microarray and epitope mapping are highlighted for producing new-generation antivenom sera. These results allow us to propose strategic solutions in the Public Health Sector for managing this disease. Keywords: antivenom, biotechnology, neglected tropical disease, omics, recombinant antibody.

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Effect of insecticide treatment time on mortality of the buthid scorpion Tityus stigmurus

Brito-Almeida

Andrade

Santos

et al. 2022

Int J Trop Insect Sci

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Factors involved in the resilience of incidence and decrease of mortality from scorpion stings in Mexico

Cited by 10 publications

References 32 publications

Amazonian scorpions and scorpionism: integrating toxinological, clinical, and phylogenetic data to combat a human health crisis in the world’s most diverse rainfores

Amazonian scorpions and scorpionism: integrating toxinological, clinical, and phylogenetic data to combat a human health crisis in the world’s most diverse rainfores

Current situation of snakebites envenomation in the Neotropics: Biotechnology, a versatile tool in the production of antivenoms.

Effect of insecticide treatment time on mortality of the buthid scorpion Tityus stigmurus

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