Factors leading to progression of valvular aortic stenosis

Bahler, Robert C.; Desser, D.R.; Finkelhor, Robert S.; Brener, Sorin J.; Youssefi, Mojtaba E

doi:10.1016/s0002-9149(99)00496-8

Cited by 107 publications

(67 citation statements)

References 26 publications

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“…4,6,11,17 In this study, nonuse of ARBs was associated with progression in early-stage subjects. Previous studies showed that ACE and angiotensin II type 1 receptor were upregulated when angiotensin II was expressed in the calcified human aortic valve compared with the normal valve.…”

Section: Prognostic Factors For Progression Of Early-stage Cavdmentioning

confidence: 59%

“…These results suggest that CAVD progression is closely related to its severity at baseline in the late-stage subjects, a conclusion that is compatible with findings from previous studies. 4,11,20 However, the mechanisms of this relationship cannot be explained by this study, and future studies are required.…”

Section: Prognostic Factors For Progression Of Early-stage Cavdmentioning

confidence: 82%

“…4,6,20 However, prognostic factors are likely to differ between the early and late stages, and moreover, the Cardiovascular Health Study has shown the effects of ethnicity on CAVD pathogenesis. 6 This retrospective study analyzed data from Japanese patients and showed that early-stage subjects with mitral regurgitation, nonuse of ARBs or warfarin use tended to undergo progression of CAVD.…”

Section: Discussionmentioning

confidence: 99%

“…2 Hypertension is a principal underlying disease, [3][4][5][6] and previous studies in Western countries have shown an association between several clinical factors and the presence and/or progression of CAVD. 3,6,7 The Cardiovascular Health Study showed that African-American ethnicity was associated with lower risk of CAVD progression.…”

Section: Introductionmentioning

confidence: 99%

“…The JASS Retrospective Analysis is a retrospective study to investigate the prognostic factors for progression of CAVD in Japanese subjects. As previous studies in Western countries suggest that prognostic factors differ according to CAVD severity, 4,6,11 the study subjects were divided on the basis of the presence of early-vs. late-stage diseases.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Prognostic factors for progression of early- and late-stage calcific aortic valve disease in Japanese: The Japanese Aortic Stenosis Study (JASS) Retrospective Analysis

Yamamoto

Yoshida

et al. 2010

Hypertens Res

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Calcific aortic valve disease (CAVD) is the most common etiology of acquired valvular heart disease, and hypertension is a principal underlying disease. The Japanese Aortic Stenosis Study (JASS) Retrospective Analysis is a retrospective observational study to clarify the prognostic factors for progression of CAVD in Japanese. Data from 556 subjects who met the following criteria were analyzed: (1) X50 years old; (2) calcification in any aortic valve leaflet or peak aortic jet velocity X2 m s À1 on an echocardiographic study performed between July 2004 and June 2007; and (3) availability of earlier echocardiographic data from within the previous 2-5 years to assess the progression of CAVD. The subjects were divided into two groups according to CAVD severity on the preceding echocardiographic examination. In early-stage subjects with calcification in one or zero leaflets who were without aortic stenosis on the preceding echocardiographic study (n¼157), the prognostic factors for progression were the following: (1) no use of angiotensin receptor blockers (ARB) and (2) use of warfarin. In late-stage subjects with calcification in two or three leaflets and/or aortic stenosis on the preceding echocardiographic study (n¼399), progression was observed in females and in subjects with low hemoglobin and a concentric left ventricle. There was no relation between medications and changes in CAVD. Prognostic factors for the progression of CAVD were different between the early and late stages. Initiation of ARB treatment during the early stage may be effective, and we should be vigilant about progression of CAVD in patients treated with warfarin.

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Section: Prognostic Factors For Progression Of Early-stage Cavdmentioning

confidence: 59%

Section: Prognostic Factors For Progression Of Early-stage Cavdmentioning

confidence: 82%