Article Info Background: Providing favorable services associated with students' behavior and health care is one of the most important tasks of school principals, and the health performance (HP) of schools is influenced by the organizational factors, such as spirituality in the workplace (SW).The purpose of this research is to predict the HP of school principals based on SW. Materials and Methods: In this descriptive study, all high school principals in Tabriz (N₌ 800) during 2018-2019 academic year were listed. Of these, 258 principals were selected through stratified random sampling in terms of location of schools. Data collection was performed using, the questionnaires of managers' HP and SW, as well as its components, including meaningful work (MW), sense of community (SOC), and the alignment of organizational values (AOV). Data were analyzed using path analysistest using PLS software. Results: The results of structural equation modeling revealed that the HP of school principals based on SW and its components was predictable. The predicted coefficient (adjusted R2)was 0.49. Furthermore, the results showed that the path coefficients of latent variables were significant (P <0.001). Conclusion: It is required to have a proper spiritual environment and pay attention to spirituality in the school workplace in order to improve the HP of school principals to provide good health services to students.