AimThis study aimed to examine the level of work engagement and to identify the factors influencing the work engagement of nurses.BackgroundWork engagement plays a crucial role in enhancing the efficiency of outcomes and the standard of care in nursing and healthcare services.MethodsA descriptive predictive design and stratified random sampling was used to select 206 nurses from three general hospitals in Naypyitaw, Myanmar.. Research instruments consisted of the demographic data form, the Utrecht Work Engagement Scale, the Global Transformational Leadership Scale, the Survey of Perceived Organizational Support, and the Psychological Capital Questionnaire. The results were explored by applying descriptive statistics and stepwise multiple regression.ResultsOverall work engagement was at an average level. Transformational leadership and psychological capital could affect work engagement, explaining 19.34% of the total variance; however, perceived organizational support, age, and work experience did not show any impact on it.ConclusionsThe findings recommend that nurse administrators should focus on transformational leadership and psychological capital in formulating strategies to increase nurses’ work engagement.Implications for nursing and health policyThe outcomes might provide baseline information for nurse administrators and policymakers by formulating management strategies to enhance nursing leaders’ awareness, knowledge, and skills about transformational leadership behaviors and to keep nurses holding self‐efficacy, hope, optimism, and resilience of psychological capital in healthcare organizations, which ultimately increase nurses’ engagement at work.