Factors predicting the sentinel node metastases in T1 breast cancer tumor:An analysis of 1416 cases

Capdet, J.; Martel, P.; Charitansky, H.; Lim, Yit; Ferron, Gwénaël; Battle, L.; Landier, A.; Mery-Lamarche, Eliane; Zerdoub, S.; Roché, H.; Querleu, Denis

doi:10.1016/j.ejso.2009.06.002

Cited by 41 publications

(36 citation statements)

References 24 publications

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“…Malignant cells invade the lymphovascular space, proliferate, and then permeate the local lymphatics or spread more widely [38]. This association is not limited to bladder cancer, and has also been shown in other cancers [39]–[41]. In addition, LVI is an important prognostic factor in various malignancies such as liver, testis, and penile cancer.…”

Section: Discussionmentioning

confidence: 82%

Prognostic Significance of Lymphovascular Invasion in Radical Cystectomy on Patients with Bladder Cancer: A Systematic Review and Meta-Analysis

Kim

Kwak

et al. 2014

PLoS ONE

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PurposeThe objective of the present study was to conduct a systematic review and meta-analysis of published literature to appraise the prognostic value of lymphovascular invasion (LVI) in radical cystectomy specimens.Materials and MethodsFollowing the PRISMA statement, PubMed, Cochrane Library, and SCOPUS database were searched from the respective dates of inception until June 2013.ResultsA total of 21 articles met the eligibility criteria for this systematic review, which included a total of 12,527 patients ranging from 57 to 4,257 per study. LVI was detected in 34.6% in radical cystectomy specimens. LVI was associated with higher pathological T stage and tumor grade, as well as lymph node metastasis. The pooled hazard ratio (HR) was statistically significant for recurrence-free survival (pooled HR, 1.61; 95% confidence interval [CI], 1.26–2.06), cancer-specific survival (pooled HR, 1.67; 95% CI, 1.38–2.01), and overall survival (pooled HR, 1.67; 95% CI, 1.38–2.01), despite the heterogeneity among included studies. On sensitivity analysis, the pooled HRs and 95% CIs were not significantly altered when any one study was omitted. The funnel plot for overall survival demonstrated a certain degree of asymmetry, which showed slight publication bias.ConclusionsThis meta-analysis indicates that LVI is significantly associated with poor outcome in patients with bladder cancer who underwent radical cystectomy. Adequately designed prospective studies are required to provide the precise prognostic significance of LVI in bladder cancer.

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Section: Discussionmentioning

confidence: 82%

Prognostic Significance of Lymphovascular Invasion in Radical Cystectomy on Patients with Bladder Cancer: A Systematic Review and Meta-Analysis

Kim

Kwak

et al. 2014

PLoS ONE

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“…The rate of axillary lymph node metastases was reported to increase from 11–36% when the tumor size increased from 10–25 mm . Furthermore, previous studies have reported that pathological tumor size is an independent predictive factor for SLN metastasis …”

Section: Discussionmentioning

confidence: 97%

Dynamic contrast‐enhanced and diffusion‐weighted MRI of invasive breast cancer for the prediction of sentinel lymph node status

Choi

Youk

Choi

et al. 2019

Magnetic Resonance Imaging

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Background Although sentinel lymph node biopsy (SLNB) is the current standard for identifying lymph metastasis in breast cancer patients, there are complications of SLNB. Purpose To evaluate preoperative dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) and diffusion‐weighted imaging (DWI) of invasive breast cancer for predicting sentinel lymph node metastasis. Study Type Retrospective. Population In all, 309 patients who underwent clinically node‐negative invasive breast cancer surgery Field Strength/Sequence 3.0T, DCE‐MRI, DWI. Assessment We collected clinicopathologic variables (age, histologic and nuclear grade, extensive intraductal carcinoma component, lymphovascular invasion, and immunohistochemical profiles) and preoperative MRI features (tumor size, background parenchymal enhancement, internal enhancement, adjacent vessel sign, whole‐breast vascularity, initial enhancement pattern, kinetic curve types, quantitative kinetic parameters, tumoral apparent diffusion coefficient [ADC], peritumoral maximal ADC, and peritumoral‐tumoral ADC ratio). Statistical Tests Multivariate logistic regressions were performed to determine independent variables associated with SLN metastasis, and the area under the receiver operating characteristic curve (AUC) was analyzed for those variables. Results 41 (13.3%) of the patients showed SLN metastasis. With MRI, tumor size (odds ratio [OR], 1.11; 95% confidence interval [CI], 1.06–1.17), heterogeneous (OR, 5.33; 95% CI, 1.71–16.58), and rim (OR, 15.54; 95% CI, 2.12–113.72) enhancement and peritumoral–tumoral ADC ratio (OR, 72.79; 95% CI, 7.15–740.82) were independently associated with SLN metastasis. Clinicopathologic variables independently associated with SLN metastasis included age (OR, 0.96; 95% CI, 0.92–0.99) and CD31 (OR, 2.90; 95% CI, 1.04–8.92). The area under the curve (AUC) of MRI features (0.80; 95% CI, 0.73–0.87) was significantly higher than for clinicopathologic variables (0.68; 95% CI, 0.60–0.77; P = 0.048) and was barely below statistical significance for combined MRI features with clinicopathologic variables (0.84; 95% CI 0.78–0.90, P = 0.057). Data Conclusion Preoperative internal enhancement on DCE‐MRI and peritumoral‐tumoral ADC ratio on DWI might be useful for predicting SLN metastasis in patients with invasive breast cancer. Level of Evidence: 3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2020;51:615–626.

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“…Among the factors identified are: age, tumour location, tumour size, tumour type, nuclear grade, lymphovascular invasion and multifocality. [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] The Breast Service of the Memorial Sloan-Kettering Cancer Center (MSKCC) developed a nomogram to assist in predicting the presence of SLN metastases in breast cancer. This nomogram is based on nine variables, identified by multivariable analysis on a dataset of 3786 patients, associated with SLN metastases: age, tumour size, tumour type, lymphovascular invasion, multifocality, nuclear grade, tumour location, oestrogen and progesterone receptor status.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Memorial Sloan-Kettering Cancer Center nomogram to predict sentinel lymph node metastases in a Dutch breast cancer population

Parra

Francissen

Peer

et al. 2013

European Journal of Cancer

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Factors predicting the sentinel node metastases in T1 breast cancer tumor:An analysis of 1416 cases

Cited by 41 publications

References 24 publications

Prognostic Significance of Lymphovascular Invasion in Radical Cystectomy on Patients with Bladder Cancer: A Systematic Review and Meta-Analysis

Prognostic Significance of Lymphovascular Invasion in Radical Cystectomy on Patients with Bladder Cancer: A Systematic Review and Meta-Analysis

Dynamic contrast‐enhanced and diffusion‐weighted MRI of invasive breast cancer for the prediction of sentinel lymph node status

Assessment of the Memorial Sloan-Kettering Cancer Center nomogram to predict sentinel lymph node metastases in a Dutch breast cancer population

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