Factors predictive of lymph node metastasis in the follicular variant of papillary thyroid carcinoma

Blanchard, Claire; Brient, C.; Volteau, Christelle; Sébag, F.; Roy, Maryline; Drui, Delphine; Hamy, A.; Mathonnet, Muriel; Henry, JF; Mirallié, Éric

doi:10.1002/bjs.9210

Cited by 22 publications

(14 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…9,26 Most researchers have reported FV PTC to be associated with a lower incidence of lymph node metastases than conventional PTC, 7,[27][28][29] although metastatic rates of up to 40% among patients with FV PTC have been reported by others. 30 In the present series, the overall rate of nodal metastatic disease in FV PTC, at under 10%, was quite low, albeit with only a small number of patients with FV PTC undergoing formal central neck dissection. Moreover, all cases of lymph node metastases in FV PTC cases occurred in tumors with infiltrative growth patterns.…”

Section: Discussioncontrasting

confidence: 50%

Follicular Variant of Papillary Thyroid Carcinoma

Sheahan

Mohamed

Ryan

et al. 2014

JAMA Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 50%

Follicular Variant of Papillary Thyroid Carcinoma

Sheahan

Mohamed

Ryan

et al. 2014

JAMA Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

show abstract

“…For this reason, the presence of nodal disease has not been included in traditional scoring systems including GAMES, from our institution, and MACIS and AMES from other centers [3][4]15]. Variables such as multifocality, lymphovascular invasion, absence of tumor capsule and extrathyroidal extension have been reported as predictors of nodal disease [16].…”

Section: • Importance Of Nodal Disease In Current Staging and Risk Stramentioning

confidence: 99%

Nodal Metastases in Thyroid Cancer: Prognostic Implications and Management

Wang

Ganly

2016

Future Oncol.

View full text Add to dashboard Cite

The significance of cervical lymph node metastases in differentiated thyroid cancer has been controversial and continues to evolve. Current staging systems consider nodal metastases to confer a poorer prognosis, particularly in older patients. Increasingly, the literature suggests that characteristics of the metastatic lymph nodes such as size and number are also prognostic. There is a growing trend toward less aggressive treatment of low-volume nodal disease. The aim of this review is to summarize the current literature and discuss prognostic and management implications of lymph node metastases in differentiated thyroid cancer.

show abstract

“…One case of PTC-FV harbored lymph node metastasis and was negative for the BRAF or NRAS mutation, while none of the PTMC-FV cases exhibited lymph node metastasis. The literature on lymph node metastasis in PTC-FV varies greatly among different studies and ranges between14% and 94% 38 .…”

Section: Discussionmentioning

confidence: 99%

BRAF and NRAS Mutations in Papillary Thyroid Carcinoma and Concordance in BRAF Mutations Between Primary and Corresponding Lymph Node Metastases

Fakhruddin

Jabbour

Novy³

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Concordance between mutations in the primary papillary thyroid carcinoma (PTC) and the paired x lymph node metastasis may elucidate the potential role of molecular targeted therapy in advanced stages. BRAF and NRAS mutations in primary PTC (n = 253) with corresponding metastatic lymph node (n = 46) were analyzed utilizing StripAssays (ViennaLab Diagnostics). Statistical analysis was performed using (SPSS, Inc.), version 24.0 with a p-value of <0.05, and concordance via kappa agreement. BRAF mutation frequency in conventional PTC (cPTC): 56.8%, papillary thyroid microcarcinoma (PTMC): 36.5%, PTMC-FV: 2.7% and PTC-FV: 4.1%. NRAS mutation frequency in PTC-FV: 28.6%, PTMC: 28.6%, PTMC-FV: 23.8%, and cPTC: 19.0%. BRAF mutation correlation with older age in cPTC (42.6 versus 33.6) years (p < 0.001) was the only significant clinicopathologic parameter. BRAF mutations were concordant in the primary and its corresponding lymph node deposits in PTC with a kappa of 0.77 (p-value < 0.0001). BRAF mutations are predominant in cPTC and PTMC while NRAS mutations in PTC-FV. BRAF mutation is conserved in metastatic lymph node deposits, thus BRAF is an early mutational pathogenetic driver. Therefore, targeted therapy is potential in recurrent and advanced stage disease.

show abstract

Factors predictive of lymph node metastasis in the follicular variant of papillary thyroid carcinoma

Abstract: The rate of lymph node metastasis in patients with FVPTC varies widely according to the presence or absence of predictive risk factors.

Cited by 22 publications

References 23 publications

Follicular Variant of Papillary Thyroid Carcinoma

Follicular Variant of Papillary Thyroid Carcinoma

Nodal Metastases in Thyroid Cancer: Prognostic Implications and Management

BRAF and NRAS Mutations in Papillary Thyroid Carcinoma and Concordance in BRAF Mutations Between Primary and Corresponding Lymph Node Metastases

Contact Info

Product

Resources

About