Factors producing a menopausal depressive-like state in mice following ovariectomy

Bekku, Naoko; Yoshimura, Hidetoshi; Araki, Hiroaki

doi:10.1007/s00213-006-0395-2

Cited by 45 publications

(51 citation statements)

References 45 publications

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“…It has been extensively studied that ovariectomy decreases estrogen level in the rodent (15,16). The prolongation of immobility shown in the forced swim test in mice after ovariectomy is also consistent with the previous study (20,21). Furthermore, the prolongation of immobility was also inhibited by repeated administration of Fuzi total alkaloid.…”

Section: Discussionsupporting

confidence: 88%

“…These data indicate that Fuzi total alkaloid has an antidepressant-like effect. To further examine the antidepressant-like behavioral effects of Fuzi total alkaloid, it was administered to ovariectomized mice, which is a useful tool for investigating menopausal depression (20,21). It has been extensively studied that ovariectomy decreases estrogen level in the rodent (15,16).…”

Section: Discussionmentioning

confidence: 99%

“…The immobility time was significantly increased in ovariectomized mice (18 -21), and they displayed depressant-like behavior. Therefore, ovariectomy is a useful tool for investigating menopausal depression (20,21). In the present study, we investigated whether Fuzi total alkaloid has an antidepressant-like behavioral effect on immobility time in the ovariectomized mice.…”

Section: Introductionmentioning

confidence: 94%

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Antidepressant-like Effect of Fuzi Total Alkaloid on Ovariectomized Mice

Liu

Zhou

et al. 2012

J Pharmacol Sci

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Abstract. Recent studies in vivo and vitro have shown that Fuzi polysaccharide has an antidepressant-like effect. Polysaccharide and total alkaloid are the two most important components of Fuzi. However, little is known about the antidepressant-like effect of Fuzi total alkaloid. To investigate the antidepressant-like effect of Fuzi total alkaloid, behavioral studies were performed in the open field test and forced swimming test. Repeated intragastric administration of Fuzi total alkaloid for 7 days (10 mg/kg) to normal mice decreased immobility time compared to the vehicle group. Furthermore, repeated administration of Fuzi total alkaloid (10 or 30 mg/kg) to ovariectomized mice also decreased immobility time in a dose-dependent manner. However, these antidepressant-like behavioral effects were not simply due to locomotor hyperactivity. Further experiments showed that Fuzi total alkaloid enhanced the ratio of phospho-CREB/CREB (cAMP response element-binding) and BDNF (brain-derived neurotrophic factor) protein level in the frontal cortex and hippocampus in ovariectomized mice but not in normal mice. These results indicate that the CREB-BDNF pathway may be involved in the antidepressant-like effect of Fuzi total alkaloid in ovariectomized mice.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

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Antidepressant-like Effect of Fuzi Total Alkaloid on Ovariectomized Mice

Liu

Zhou

et al. 2012

J Pharmacol Sci

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“…Experiment 1a determined that three days of PWD was required to detect a significant increase in FST immobility. This finding is consistent with recent reports of delayed increases in FST immobility following steroid withdrawal (Bekku et al, 2007;Stoffel & Craft, 2004), and of increased depression-like behavior in rats at three days postpartum, as assessed in the differential reinforcement of low response-rate model of depression (Molina-Hernández et al, 2000). In the case of Stoffel and Craft (2004), rats received progesterone and estradiol injections, separately or in combination, for a period of more than three weeks.…”

supporting

confidence: 92%

“…These bidirectional manipulations of ALLO levels provide evidence for an inverse relationship between ALLO levels and FST immobility, albeit not in the context of PWD. In contrast, the efforts of other researchers (e.g., Bekku et al, 2007;Molina-Hernández et al, 2000) have reported depression-like effects of PWD, but without specifically assessing potential mechanisms underlying the effect. Thus, FST immobility was previously studied in the context of acute ALLO manipulation or progesterone withdrawal, and the current research combines these lines of research.…”

Section: Discussionmentioning

confidence: 91%

Inhibition of progesterone metabolism mimics the effect of progesterone withdrawal on forced swim test immobility

Beckley¹,

Finn²

2007

Pharmacology Biochemistry and Behavior

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Withdrawal from high levels of progesterone in rodents has been proposed as a model for premenstrual syndrome or postpartum depression. Forced swim test (FST) immobility, used to model depression, was assessed in intact female DBA/2J mice following progesterone withdrawal (PWD) or treatment with the 5α-reductase inhibitor finasteride. Following 5 daily progesterone injections (5 mg/kg IP) FST immobility increased only in mice withdrawn for 3 days (p < .05). In another experiment, 3 days of PWD significantly decreased levels of progesterone compared to 0 days of withdrawal, but progesterone levels at 3 days of PWD did not differ from vehicle-treated controls. In a final study, mice received daily injections of progesterone (5 mg/kg IP) for 8 days, with 0 mg/ kg, 50 mg/kg, or 100 mg/kg finasteride co-administered for the last three days. Mice that received 100 mg/kg finasteride, but not 50 mg/kg finasteride, displayed increased FST immobility. PWD and finasteride treatment, both of which reduce allopregnanolone levels, were associated with increased FST immobility in female DBA/2J mice. These findings suggest that decreased levels of the GABAergic neurosteroid allopregnanolone contributes to symptoms of PWD. Future studies of PWD may provide information about human conditions that are associated with hormone changes such as premenstrual syndrome or postpartum depression. KeywordsDepression; premenstrual syndrome; postpartum depression; progesterone withdrawal; behavioral despair; GABA-A receptor; allopregnanolone; finasteride Beginning in adolescence, females experience affective disorders at higher rates than males, partially due to sex-specific disorders such as premenstrual syndrome (PMS) and postpartum depression (McGrath et al., 1990,Steiner et al., 2003. Progesterone secretion is dramatically reduced prior to menstruation or following childbirth. These periods of progesterone clearance have been called "progesterone withdrawal" (PWD), and are associated with dynamic (but species-dependent) biological events in females (MacDonald et al., 1991). Given the temporal Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. association between PWD and PMS or postpartum depression, studies that elucidate the effects of PWD may lead to increased understanding of these disorders. NIH Public AccessEmerging evidence about the cellular actions of progesterone and its metabolites in the brain has stimulated research regarding neuroendocrine correlates of behaviors. In addition to the actions of progesterone on intracellular and membrane-bound receptors, progesterone can be metaboli...

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Efficacy of Estradiol in Perimenopausal Depression: So Much Promise and So Few Answers

et al. 2015

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Factors producing a menopausal depressive-like state in mice following ovariectomy

Abstract: The present findings have potentially important implications for evaluating a candidate substance for the management of mood disorders in menopausal women.

Cited by 45 publications

References 45 publications

Antidepressant-like Effect of Fuzi Total Alkaloid on Ovariectomized Mice

Antidepressant-like Effect of Fuzi Total Alkaloid on Ovariectomized Mice

Inhibition of progesterone metabolism mimics the effect of progesterone withdrawal on forced swim test immobility

Efficacy of Estradiol in Perimenopausal Depression: So Much Promise and So Few Answers

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