Factors regulating insulin-like growth factor binding protein-3 secretion from human hepatoma (HepG2) cells

Kalme, Tarja; Loukovaara, Mikko; Koistinen, Hannu; Koistinen, R; Seppälä, Markku; Leinonen, Pekka

doi:10.1016/s0960-0760(01)00089-9

Cited by 10 publications

(7 citation statements)

References 25 publications

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“…Nevertheless, increased serum levels of IGFBP3 have also been reported by Hokken-Koelega [12 ]in a study of renal Tx patients on steroids and in patients with Cushing's syndrome [13]. Currently, known factors regulating IGFBP3 secretion in humans include Insulin, IGF-I, and IGF-II [14]. Steroids may play a direct regulating role, or an indirect role through insulin, in IGFBP3 synthesis or degradation.…”

Section: Discussionmentioning

confidence: 96%

Steroid Withdrawal in Pediatric Kidney Transplant Allows Better Growth, Lipids and Body Composition: A Randomized Controlled Trial

Mericq

Salas²,

Pinto³

et al. 2013

Horm Res Paediatr

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Background: Glucocorticoid immunosuppressant therapy in pediatric kidney transplant (Tx) recipients does not allow the improvement of growth after Tx. Objective: To determine the effect of early steroid withdrawal (SW) on longitudinal growth, insulin sensitivity (IS), and body composition (BC). Methods: This was a prospective, randomized, multicenter study in Tx. Insulin-like growth factor (IGF)-I, IGF-binding protein 3 (IGFBP3), IS, and BC (DEXA/pQCT) were determined at baseline and up to 12 months after Tx. Results: A total of 30 patients were examined; 14 patients were assigned to the SW group (7 male, 7 female; 12 in Tanner stage I) and 16 patients were assigned to the steroid control (SC) group (10 male, 6 female;12 in Tanner stage I). Their chronological age was 7.8 ± 4.3 years, height was -2.3 ± 0.99 SD scores (SDS), and body mass index -0.3 ± 1.2 SDS. After 1 year, the SW group showed an increase in height SDS (+1.2 ± 0.22 vs. +0.60 ± 0.13 SDS in the SC group, p < 0.02), lower IGFBP3 (p < 0.05), cholesterol (p < 0.05), and higher high-density lipoprotein cholesterol (p < 0.05). SW patients had lower trunk fat with no differences in IS. Only in prepubertal patients, the SW group had lower glycemia (p < 0.05), very low-density lipoprotein cholesterol (p < 0.01), triglycerides (p < 0.05), triglycerides/glycemia index (TyG; p < 0.02), and better lean mass. Both groups showed an improvement in lean mass after kidney Tx. Conclusions: SW improved longitudinal growth, lipid profile, and trunk and lean fat in Tx patients. In prepubertal recipients, the decrease in TyG suggests better IS.

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Section: Discussionmentioning

confidence: 96%

Steroid Withdrawal in Pediatric Kidney Transplant Allows Better Growth, Lipids and Body Composition: A Randomized Controlled Trial

Mericq

Salas²,

Pinto³

et al. 2013

Horm Res Paediatr

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“…Indeed, insulin has been shown to regulate IGF-BP3 levels in GDM pregnancy [30]. Moreover, insulin and IGF-I treatment in vitro also stimulates the secretion of IGF-BP3 [31]. …”

Section: Discussionmentioning

confidence: 99%

Growth factor concentrations and their placental mRNA expression are modulated in gestational diabetes mellitus: possible interactions with macrosomia

Grissa

Yessoufou

Mrisak

et al. 2010

BMC Pregnancy Childbirth

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BackgroundGestational diabetes mellitus (GDM) is a form of diabetes that occurs during pregnancy. GDM is a well known risk factor for foetal overgrowth, termed macrosomia which is influenced by maternal hypergycemia and endocrine status through placental circulation. The study was undertaken to investigate the implication of growth factors and their receptors in GDM and macrosomia, and to discuss the role of the materno-foeto-placental axis in the in-utero regulation of foetal growth.Methods30 women with GDM and their 30 macrosomic babies (4.75 ± 0.15 kg), and 30 healthy age-matched pregnant women and their 30 newborns (3.50 ± 0.10 kg) were recruited in the present study. Serum concentrations of GH and growth factors, i.e., IGF-I, IGF-BP3, FGF-2, EGF and PDGF-B were determined by ELISA. The expression of mRNA encoding for GH, IGF-I, IGF-BP3, FGF-2, PDGF-B and EGF, and their receptors, i.e., GHR, IGF-IR, FGF-2R, EGFR and PDGFR-β were quantified by using RT-qPCR.ResultsThe serum concentrations of IGF-I, IGF-BP3, EGF, FGF-2 and PDGF-B were higher in GDM women and their macrosomic babies as compared to their respective controls. The placental mRNA expression of the growth factors was either upregulated (FGF-2 or PDGF-B) or remained unaltered (IGF-I and EGF) in the placenta of GDM women. The mRNA expression of three growth factor receptors, i.e., IGF-IR, EGFR and PDGFR-β, was upregulated in the placenta of GDM women. Interestingly, serum concentrations of GH were downregulated in the GDM women and their macrosomic offspring. Besides, the expression of mRNAs encoding for GHR was higher, but that encoding for GH was lower, in the placenta of GDM women than control women.ConclusionsOur results demonstrate that growth factors might be implicated in GDM and, in part, in the pathology of macrosomia via materno-foeto-placental axis.

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“…Greater nutrient availability can, in turn, increase IGF-1 levels (Thissen, Ketelslegers & Underwood, 1994). Vagal stimulation also promotes the release of insulin (Rozman, Bunc & Zorko, 2004), and insulin has been shown to stimulate the synthesis and release of IGF-1 (Kalme, Loukovaara, Koistinen, Koistinen, Seppala & Leinonen, 2001; Thissen et al, 1994). The stimulation of pressure receptors can also promote the release of insulin (Marchini, Lagercrantz, Feuerberg, Winberg, Uvnas-Moberg, 1987).…”

Section: Moderate Pressure Is Criticalmentioning

confidence: 99%

Preterm infant massage therapy research: A review

Field¹,

Diego²,

Hernandez‐Reif³

2010

Infant Behavior and Development

227

150

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In this paper, preterm infant massage therapy studies are reviewed. Massage therapy has led to weight gain in preterm infants when moderate pressure massage was provided. In studies on passive movement of the limbs, preterm infants also gained significantly more weight, and their bone density also increased. Research on ways of delivering the massage is also explored including using mothers versus therapists and the added effects of using oils. The use of mothers as therapists was effective in at least one study. The use of oils including coconut oil and safflower oil enhanced the average weight gain, and the transcutaneous absorption of oil also increased triglycerides. In addition, the use of synthetic oil increased vagal activity, which may indirectly contribute to weight gain. The weight gain was associated with shorter hospital stays and, thereby, significant hospital cost savings. Despite these benefits, preterm infant massage is only practiced in 38% of neonatal intensive care units. This may relate to the underlying mechanisms not being well understood. The increases noted in vagal activity, gastric motility, insulin and IGF-1 levels following moderate pressure massage are potential underlying mechanisms. However, those variables combined do not explain all of the variance in weight gain, highlighting the need for additional mechanism studies.

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Factors regulating insulin-like growth factor binding protein-3 secretion from human hepatoma (HepG2) cells

Cited by 10 publications

References 25 publications

Steroid Withdrawal in Pediatric Kidney Transplant Allows Better Growth, Lipids and Body Composition: A Randomized Controlled Trial

Steroid Withdrawal in Pediatric Kidney Transplant Allows Better Growth, Lipids and Body Composition: A Randomized Controlled Trial

Growth factor concentrations and their placental mRNA expression are modulated in gestational diabetes mellitus: possible interactions with macrosomia

Preterm infant massage therapy research: A review

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