Factors related to allergic transfusion reactions and febrile non‐haemolytic transfusion reactions in children

Abstract

These results suggest that leucocytes or mediators from leucocytes are underlying cause of ATRs in addition to FNHTRs in children. Furthermore, particular characteristics of patients would be other risk factors for ATRs.

Administration of platelet concentrates suspended in bicarbonated Ringer's solution in children who had platelet transfusion reactions

“…All patients were transfused with 10 units of regular PCs in plasma, including 2 × 10 11 /l platelets, regardless of body weight. All regular PCs in plasma were supplied after nucleic acid testing for HBV, HCV and HIV at the Japanese Red Cross Blood Center; thereafter, the components were exposed to irradiation ranging from 15 to 50 Gy and were used within 4 days of apheresis . Washed PCs were prepared at the Nagano Children's Hospital according to the guidelines of the Japan Society of Transfusion Medicine and Cell Therapy .…”

“…All reported and suspected transfusion‐related adverse reactions and symptoms in the study period were reviewed by a specialist of blood transfusion. We assessed the type of ATRs as described previously . ATR was defined as the presence of at least one of the following during or within 4 h of transfusion: maculopapular rash with/without pruritus; urticaria; pruritus; generalized flushing; localized angioedema; oedema of lips, tongue and uvula; erythema and oedema of the periorbital area; conjunctival oedema; respiratory distress; bronchospasm; and hypotension.…”

Leukocyte and plasma activation profiles in chronically transfused patients with a history of allergic reactions

“…1,2 ATRs are moderately frequent adverse events reported in 0.4 to 3% of all transfusions. [3][4][5][6] Although their reported incidence varies widely, ATRs are considered to be more common with plasma-containing products. 3 Recent surveys report occurrence rates of 0.3 to 6% with platelet transfusions, 1 to 3% with plasma transfusions, and only 0.03 to 0.61% with red blood cell (RBC) transfusions.…”

“…7 In a single-center, retrospective analysis of transfusion reactions in children, leukocyte-mediated effects were primarily associated with these adverse events, although recipient characteristics also appeared to play a significant role. 6,11 In a retrospective study of apheresis platelet split products, 12 the observance of an ATR in a patient receiving one split did not predict the occurrence of an ATR in another patient who received transfusion of the other split from the same product, 12 suggesting the existence of patient-specific predisposition factors.…”

“…Current management is most often based on antihistamines, such as diphenhydramine, which does not fully prevent these reactions . ATRs are moderately frequent adverse events reported in 0.4 to 3% of all transfusions . Although their reported incidence varies widely, ATRs are considered to be more common with plasma‐containing products .…”