Factors Related to Complying with Anti-TB Medications Among Drug-Resistant Tuberculosis Patients in Indonesia

Abstract

Background A variety of factors influenced the decision of tuberculosis (TB) drug-resistant patients to continue treatment. The study aimed to analyze factors that influence complying with anti-TB medications in patients with TB drug resistance in Indonesia. Patients and Methods The study employed a cross-sectional approach and was conducted in various community health centers and polyclinics offering TB drug-resistant services in Bandung city, Indonesia. Participants were 79 patients with TB drug resistance who met the criteria during their treatment for TB drug resistance, were willing to be involved in the research, and accessed TB services in Bandung. Complying with anti-TB medications scale, TB Health Behaviors questionnaire, the family support questionnaire, the TB-Related Stigma Scale, and TB knowledge were used in this study. Data were analyzed using Spearman’s Rho. Results Health behavior (r = 0.36) was positively associated with complying with anti-TB medications, while family support, TB stigma, and knowledge were not related to treatment compliance. Conclusion Information on these factors will inform the development of models and modules for the prevention and control of TB drug resistance in Indonesia, which can later be used widely in Indonesia.

A Comprehensive Review on Long vs. Short Regimens in Multidrug-Resistant Tuberculosis (MDR-TB) Under Programmatic Management of Drug-Resistant Tuberculosis (PMDT)

“…A study conducted in Chongqing, China, highlighted that patients aged 55 or older, migrants, those lacking prior MDR-TB case management, unmarried individuals, and females were associated with poor adherence behavior (p<0.05) [ 17 ]. In Indonesia, a study identified a positive correlation between health insurance and medication adherence, noting that TB patients with high medication adherence exhibited a more favorable quality of life [ 16 ].…”

“…The successful treatment of MDR-TB hinges on patient adherence and compliance, with various factors influencing these crucial components. Demographic factors, socioeconomic status, health insurance, and the potential impact of treatment side effects are key determinants [15][16][17]. A study conducted in Chongqing, China, highlighted that patients aged 55 or older, migrants, those lacking prior MDR-TB case management, unmarried individuals, and females were associated with poor adherence behavior (p<0.05) [17].…”

Article Review: The Treatment Problem and Adverse Drug Reactions in the Treatment of Multidrug-Resistant Tuberculosis

“…MDR-TB treatment involves the use of second-line OAT, although more complex, and is associated with more severe side effects than first-line OAT, contributing to a higher dropout rate (Farihatun et al, 2018). A research study in Indonesia indicated a 91.1% compliance rate influenced by patient-related factors, condition-related factors, and treatment-related factors, including ADRs, socio-economic factors, and health service system factors (Yani et al, 2022).…”