Factors related to delay in diagnosis of oral squamous cell carcinoma in southern Thailand

Kerdpon, Duangporn; Sriplung, Hutcha

doi:10.1016/s1368-8375(00)00072-5

Cited by 73 publications

(105 citation statements)

References 19 publications

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“…Multiple factors may also contribute to advanced stage at presentation, including personal factors, health education, health care access, or others. The previous study from our hospital has revealed that having herbal medicine before seeking professional health care provider is significantly associated with advanced stage at presentation in oral cancer patients (Kerdpon and Sriplung, 2001). Delayed seeking of care by physicians allows cancer to progress, resulting in advanced disease at presentation.…”

Section: Discussionmentioning

confidence: 89%

Survival and Prognostic Factors of Different Sites of Head and Neck Cancer: An Analysis from Thailand

Pruegsanusak¹,

Peeravut²,

Leelamanit³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 89%

Survival and Prognostic Factors of Different Sites of Head and Neck Cancer: An Analysis from Thailand

Pruegsanusak¹,

Peeravut²,

Leelamanit³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…The study indicated that the professional delay was the most associated variable to the stage of tumor. 6 In this study maximum number, i.e., 80 patients (80%) presented within 6 months of onset of symptoms. This can be attributed to the fact that because of poverty, illiteracy, and possibly resorting to home remedies, all leading to delay by the patients.…”

Section: Discussionmentioning

confidence: 69%

Clinical study on oral cancer among adults: a hospital based cross sectional study

Venukumar¹

2017

Int Surg J

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Background: Oral cancer is a highly preventable disease, being caused by the use of tobacco and its products, either with or without alcohol. According to WHO research, 50% increase in oral cancers by the year 2025 is expected. Methods: Detailed history was recorded in a proforma, regarding age, sex, presenting complaints, habits of chewing tobacco, pan and gutkha, habit of smoking and consumption of alcohol. Thorough examination of oral cavity was done and site of growth was noted. Results: Classification of TNM staging found that 56% of patients were in a stage of IVA, 31% were in stage III and remaining 13% were in stage. Conclusions: Lymph node status varied significantly according to size and depth of infiltration of lesion.

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“…In order to prevent the increasing incidence of squamous cell carcinoma of the head and neck, there is an urgent need for educational campaigning against tobacco, betel leaves and nut and alcohol consumption. 10 Also, the high risk populations should be screened early and the importance of diagnosing the disease early for the survival of the patient should be emphasized. Early diagnosis could also improve the quality of life and reduce cost of treatment in patients with squamous cell carcinoma of the head and neck.…”

Section: Discussionmentioning

confidence: 99%

Secondary neck nodes from squamous cell carcinoma: a study of 67 patients from Tamil Nadu

Sundresh¹,

Narendran

Subramanian³

2015

Int Surg J

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INTRODUCTIONSquamous cell carcinoma of the head and neck primarily comprising of local invasion and subsequent cervical lymph node metastasis is one of the most aggressive cancer types. The mortality rate in a period of 2 years, owing to metastasis is 88%.1 Declining patient survival in head and neck squamous cell carcinoma is closely associated with distal metastasis.2 The invasion is a multistep process that involves the breaching of the basement membrane, migration of the tumor cell through the extracellular matrix (ECM) of the stroma. This is followed by intravasation through the vasculature and subsequent extravasation in the site of metastasis. Protein degradation in the extracellular matrix is one of the key steps that facilitate spreading of the tumor cells. Also, genetic studies have proved that the involvement of genes encoding for angiogenic factors is crucial for the development of squamous cell carcinoma of the head and neck. This is because of the fact that the extent of neovascularization near the tumor is determined by the complex interplay between the negative and positive regulators of angiogenesis.Risk factors like poor oral hygiene, non-vegetarian food, poor dentition, smoking, tobacco chewing, and alcohol ABSTRACT Background: In the present study, nine areas of the head and neck inclusive of five primary sites in the oral cavity and three in the oropharynx and the maxillary antrum were examined in the patients presenting with squamous cell carcinoma of the head and neck. Methods: 67 subjects with histologically proven squamous cell carcinoma with varying degrees of differentiation were included in the study. Results: It was found that 20% of the patients were in the age group of 31 to 40 years, 55% were in the age group of 41-50 years, 16.6% were in the age groups of 51 to 60 years and 8.3% were in the age group of 61 to 70 years. In patients with lesions smaller than 2 cm, 44.44% percent subjects had cervical node metastases; whereas in patients with lesion size between 2.1 to 4 cm, 75% had cervical node metastases. However, in subjects with lesion size above 4 cm, 100 % of the patients had cervical node metastases. Patients with large primaries of greater than 4 cm and those with higher histological grade ranging from moderate to poorly differentiated metastases showed a greater prevalence of nodal regional metastases compared to the rest. With decreasing degree of differentiation, an increased prevalence of nodal metastases was observed. Conclusions: This study suggests an early age of occurrence of squamous cell carcinoma in our population and increase in cervical nodal metastases with increasing tumor size and decrease in degree of differentiation.

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Factors related to delay in diagnosis of oral squamous cell carcinoma in southern Thailand

Cited by 73 publications

References 19 publications

Survival and Prognostic Factors of Different Sites of Head and Neck Cancer: An Analysis from Thailand

Survival and Prognostic Factors of Different Sites of Head and Neck Cancer: An Analysis from Thailand

Clinical study on oral cancer among adults: a hospital based cross sectional study

Secondary neck nodes from squamous cell carcinoma: a study of 67 patients from Tamil Nadu

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