Factors Related to Depression According to the Degree of Loneliness in Adolescents with Severe Friend-Relationship Stress

Park, Hyeok Gyu; Jeong, Sunkyung; Kwon, Myoungjin

doi:10.3390/healthcare11091354

Cited by 4 publications

(3 citation statements)

References 28 publications

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“…Furthermore, loneliness influences substance use via depression. The lack or loss of social relationships leads to social pain, such as loneliness, and social pain leads to depression, decreased self-control, and low self-esteem [ 12 , 27 , 28 ]. Therefore, loneliness can lead to depression, which, in turn, can lead to substance consumption.…”

Section: Discussionmentioning

confidence: 99%

“…Loneliness has several negative effects on adolescents [ 8 , 9 , 10 , 11 ]. It is associated with academic obstacles, such as maladjustment to school life and poor academic achievements [ 9 , 12 ]; emotional problems, such as depression, increased suicide risk, and the persistence of loneliness into adulthood [ 9 , 11 , 12 ]; increased physical issues, such as increased morbidity, and early mortality [ 9 ]; and increased substance use, such as smoking, drinking, and drug use [ 8 , 9 ]. Psychological distress resulting from loneliness can make adolescents more vulnerable to substance use [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

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The Mediating Effect of Depression on the Relationship between Loneliness and Substance Use in Korean Adolescents

Kim

2024

Behavioral Sciences

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Substance use among adolescents is a major emerging health problem worldwide. Although loneliness and depression are major risk factors for substance use, few studies have examined the relationship between loneliness, depression, and substance use in adolescents. This study aimed to determine the mediating effect of depression on the relationship between loneliness and substance use among Korean adolescents, based on the data from 53,310 adolescents from the 17th Korea Youth Risk Behavior Web-based Survey in 2021. Using a complex sample analysis module, hierarchical logistic regression analysis was employed to confirm the mediating effect of depression on the relationship between loneliness and substance use. The results showed that loneliness and depression have a significant effect on substance use (smoking, drinking alcohol, and drug use). Depression was found to have a partial mediating effect on the relationship between loneliness and substance use. Overall, the results suggested that loneliness and depression in adolescents increase substance use, and loneliness can affect substance use through depression. Therefore, proactive strategies to prevent and reduce loneliness and depression in adolescents can be effective in preventing substance use.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Mediating Effect of Depression on the Relationship between Loneliness and Substance Use in Korean Adolescents

Kim

2024

Behavioral Sciences

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“…Numerous studies have shown that psychosocial factors can precipitate depression as well as mania [6,7]. However, most people who are exposed to stressful events do not develop a psychiatric disorder [8][9][10][11]. This begs the question: why do some people develop an emotional disorder about a stressful life event and others do not?…”

Section: Introductionmentioning

confidence: 99%

Epigenetic and Coping Mechanisms of Stress in Affective Disorders: a Scoping Review

Bernad,

Tomescu,

Teodora

et al. 2024

Preprint

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This review aims to explore the intricate relationship between epigenetic mechanisms, stress, and affective disorders, focusing on how early life experiences and coping mechanisms contribute to susceptibility to mood disorders. Epigenetic factors play a crucial role in regulating gene expression without altering the DNA (deoxyribonucleic acid) sequence, and recent research has revealed associations between epigenetic changes and maladaptive responses to stress or psychiatric disorders. A scoping review of 33 studies employing the PRISMA-S (Preferred Reporting Items for Systematic Reviews and Meta-Analyses – Statement) guidelines investigates the role of stress-induced epigenetic mechanisms and coping strategies in affective disorders' occurrence, development, and progression. The analysis encompasses various stress factors, including childhood trauma, work-related stress, and dietary deficiencies, alongside epigenetic changes such as DNA methylation and altered gene expression. Findings indicate that specific stress-related genes frequently exhibit epigenetic changes associated with affective disorders. Moreover, the review examines coping mechanisms in patients with bipolar disorder and major depressive disorder, revealing mixed associations between coping strategies and symptom severity. While active coping is correlated with better outcomes, emotion-focused coping may exacerbate depressive or manic episodes. Overall, this review underscores the complex interplay between genetic predisposition, environmental stressors, coping mechanisms, and affective disorders. Understanding these interactions is essential for developing targeted interventions and personalized treatment strategies for individuals with mood disorders. However, further research is needed to elucidate specific genomic loci involved in affective disorders and the clinical implications of coping strategies in therapeutic settings.

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Epigenetic and Coping Mechanisms of Stress in Affective Disorders: A Scoping Review

Bernad,

Tomescu,

Anghel

et al. 2024

Medicina

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This review aims to explore the intricate relationship among epigenetic mechanisms, stress, and affective disorders, focusing on how early life experiences and coping mechanisms contribute to susceptibility to mood disorders. Epigenetic factors play a crucial role in regulating gene expression without altering the DNA (deoxyribonucleic acid) sequence, and recent research has revealed associations between epigenetic changes and maladaptive responses to stress or psychiatric disorders. A scoping review of 33 studies employing the PRISMA-S (Preferred Reporting Items for Systematic Reviews and Meta-Analyses—Statement) guidelines investigates the role of stress-induced epigenetic mechanisms and coping strategies in affective disorder occurrence, development, and progression. The analysis encompasses various stress factors, including childhood trauma, work-related stress, and dietary deficiencies, alongside epigenetic changes, such as DNA methylation and altered gene expression. Findings indicate that specific stress-related genes frequently exhibit epigenetic changes associated with affective disorders. Moreover, the review examines coping mechanisms in patients with bipolar disorder and major depressive disorder, revealing mixed associations between coping strategies and symptom severity. While active coping is correlated with better outcomes, emotion-focused coping may exacerbate depressive or manic episodes. Overall, this review underscores the complex interplay among genetic predisposition, environmental stressors, coping mechanisms, and affective disorders. Understanding these interactions is essential for developing targeted interventions and personalized treatment strategies for individuals with mood disorders. However, further research is needed to elucidate specific genomic loci involved in affective disorders and the clinical implications of coping strategies in therapeutic settings.

show abstract

Factors Related to Depression According to the Degree of Loneliness in Adolescents with Severe Friend-Relationship Stress

Cited by 4 publications

References 28 publications

The Mediating Effect of Depression on the Relationship between Loneliness and Substance Use in Korean Adolescents

The Mediating Effect of Depression on the Relationship between Loneliness and Substance Use in Korean Adolescents

Epigenetic and Coping Mechanisms of Stress in Affective Disorders: a Scoping Review

Epigenetic and Coping Mechanisms of Stress in Affective Disorders: A Scoping Review

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