Factors related to gastric neuroendocrine tumors

Soto-Solís, Rodrigo; Romano-Munive, Adriana Fabiola; Anda, K. Santana de; Barreto-Zúñiga, Rafael

doi:10.1016/j.rgmxen.2018.06.007

Cited by 7 publications

(4 citation statements)

References 10 publications

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“…Although it causes ECL cell hyperplasia in humans, it is controversial whether it affects tumor development [8,17]. While there are more case reports in the literature, there are very few studies on this subject [2,[9][10][11][12][13]18]. While no relationship was found between NET and PPI use in one of the existing studies, it was reported in another study that it was related and that NETs with less aggressive behavior emerged [13,18].…”

Section: Discussionmentioning

confidence: 99%

Metastatic multiple gastric neuroendocrine tumors with a long history of proton pump inhibitor use: A case report

Erhan

Buğra²,

Keser

et al. 2022

J Surg Med

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It is widely accepted that gastric neuroendocrine tumors (NETs) develop due to enterochromaffin-like (ECL) cell proliferation following exposure to hypergastrinemia, which causes hyperplastic-dysplastic-neoplastic changes. Here we describe the case of a 46-year-old female patient diagnosed with metastatic NETs by liver biopsy and evaluated at an external center. At our hospital, nodular structures extending from the cardia to the antrum were observed by gastroscopy, considered the primary tumor focus. Histopathological examination revealed a trabecular-insular pattern, with microNETs consisting of monotone cells with round-oval nuclei and surrounding neuroendocrine cell hyperplasia foci and fundic gland polyps. The patient had a history of regular proton pump inhibitor (PPI) use for 10 years and a serum gastrin of 9240 pg/mL. A 3-cm metastatic lesion in the left lobe of the liver was observed in whole-body imaging with octreotide. By gastrectomy, we observed a large number of nodular lesions in the corpus-antrum and a 3-cm diameter lesion in the hepatectomy material. Histopathological examination revealed NETs in multiple foci with submucosal invasion in the stomach. The Ki-67 proliferative index was 3%. Metastatic tumors of similar morphology were found in the liver and three of the greater curvature lymph nodes. We made a diagnosis of multiple gastric NETs (Grade 2). In Type I gastric NETs, the neuroendocrine cell proliferation spectrum up to NET is observed as a result of hypergastrinemia due to atrophic gastritis. Also, in experimental studies, prolonged hypergastrinemia has been reported to cause ECL cell neoplasms in animals treated with PPIs. Although our case could be accepted as Type 1 NET, the possibility of developing NET secondary to long-term PPI use should also be considered.

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Section: Discussionmentioning

confidence: 99%

Metastatic multiple gastric neuroendocrine tumors with a long history of proton pump inhibitor use: A case report

Erhan

Buğra²,

Keser

et al. 2022

J Surg Med

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“…This alteration leads finally to the development of NEN[ 40 ]. Long term proton pump inhibitor use enhances the development of g-NEN in animal studies and case reports[ 41 , 42 ], but various studies showed that chronic proton pump inhibitor use or vagotomy has no effect on g-NEN development[ 29 , 43 ]. This fact proves that hypergastrinemia is essential for type 1 g-NEN development but is not sufficient.…”

Section: Pathogenesis Of Nens Of the Stomachmentioning

confidence: 99%

Gastric neuroendocrine neoplasms: A review

Köseoğlu¹,

Düzenli²,

Sezıklı³

2021

WJCC

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Gastric neuroendocrine neoplasms (g-NENs) or neuroendocrine tumors are generally slow-growing tumors with increasing incidence. They arise from enterochromaffin like cells and are divided into four types according to clinical characteristic features. Type 1 and 2 are gastrin dependent, whereas type 3 and 4 are sporadic. The reason for hypergastrinemia is atrophic gastritis in type 1, and gastrin releasing tumor (gastrinoma) in type 2 g-NEN. The diagnosis of g-NENs needs histopathological investigation taken by upper gastrointestinal endoscopy. g-NENs are positively stained with chomogranin A and synaptophysin. Grading is made with mitotic index and ki-67 proliferation index on histopathological analysis. It is crucial to discriminate between types of g-NENs, because the management, treatment and prognosis differ significantly between subtypes. Treatment options for g-NENs include endoscopic resection, surgical resection with or without antrectomy, medical treatment with somatostatin analogues, netazepide or chemotherapy regimens. Follow-up without excision is another option in appropriate cases. The prognosis of type 1 and 2 g-NENs are good, whereas the prognosis of type 3 and 4 g-NENs are close to the prognosis of gastric adenocancer.

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“…Otro estudio realizado teniendo en cuenta la última clasificación de OMS determinó que dos tercios fueron de bajo grado 23 . En el estudio de Flórez y Col, predominaron los tumores bien diferenciados de grado intermedio o G2 [19] .…”

Section: Característica N (%)unclassified

“…En el presente estudio, dentro de los tumores neuroendocrinos localizados en pulmón, una tercera parte fueron bien diferenciados, similar al reportado en otras investigaciones [21] , pero con grandes diferencias con respecto a los pobremente diferenciados, siendo menos frecuente en este estudio. De igual manera, se evidenció que hasta un tercio tenían antecedente de tabaquismo, menor comparado con el estudio realizado por Soto-Solís y col. [22] , reportaron que la mayoría de los tumores pulmonares fueron de alto grado [19] .…”

Section: Característica N (%)unclassified

Características clínicas y demográficas de una población adulta con tumores neuroendocrinos

Montalvo¹,

Muñoz-Delgado

Ledesma³

et al. 2021

Acta Med Peru

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Introducción:Los tumores neuroendocrinos representan un grupo de neoplasias de baja incidencia que derivan de células neuroendocrinas distribuidas en todo el cuerpo en especial sistema respiratorio y gastrointestinal. Objetivo: Determinar las características clínicas y sociodemográficas de una población adulta con padecimiento de tumores neuroendocrinos. Materiales y métodos: Estudio descriptivo transversal, se evaluaron 91 historias clínicas con diagnóstico de tumores neuroendocrinos confirmados por patología entre los años 2013 a 2020. Análisis realizado en Microsoft Excel 2013 y EpiInfo 7.2. Resultados: La media de edad fue 61 años, con predominio en hombres (57%). Los principales antecedentes fuero el tabaquismo (35%), hipertensión arterial (22%) y EPOC (9%). Los principales síntomas fueron el dolor abdominal (43%), pérdida de peso (31%) y tos (26%). Según el origen, fueron más frecuentes los de intestino anterior (75%), predominando los de tracto respiratorio (39,5%). En el 21,9%, el origen fue desconocido. Teniendo en cuenta la clasificación 2019 de la OMS, predominaron los carcinomas neuroendocrinos (56%), de los cuales el más frecuente fue el carcinoma de células pequeñas. Entre los bien diferenciados (44%), fueron más frecuentes los de bajo grado (58%) seguido grado intermedio (24%) y bajo grado (17%). Las metástasis se registraron en 37% de los casos con afectación principalmente hepática (49%), ganglios (21%) y sistema nervioso central (9%). La mortalidad se presentó en el 24% de los casos. Conclusiones: Los resultados del presente estudio concuerdan con lo reportado a nivel mundial, resaltando el predominio de los tumores de origen pulmonar, como también clínica semejante según los órganos afectados.

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Factors related to gastric neuroendocrine tumors

Cited by 7 publications

References 10 publications

Metastatic multiple gastric neuroendocrine tumors with a long history of proton pump inhibitor use: A case report

Metastatic multiple gastric neuroendocrine tumors with a long history of proton pump inhibitor use: A case report

Gastric neuroendocrine neoplasms: A review

Características clínicas y demográficas de una población adulta con tumores neuroendocrinos

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