Factors related to low serum vitamin <scp>B</scp><sub>12</sub> levels in elderly patients with non‐atrophic gastritis in contrast to patients with normal vitamin <scp>B</scp><sub>12</sub> levels

Kalkan, Çağdaş; Karakaya, Fatih; Tüzün, Ali; Gençtürk, Zeynep; Soykan, İrfan

doi:10.1111/ggi.12537

Cited by 11 publications

(8 citation statements)

References 26 publications

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“…also demonstrated an association between copper levels and high titers of anti‐ H. pylori IgA in patients with IDA, possibly playing a role in the disease. As reported by Kalkan et al, H. pylori infection may be more often diagnosed in older patients whose serum vitamin B12 levels were 200 pg/mL; moreover, the same levels show an inverse relation with H. pylori density …”

Section: Hematologic Diseasesmentioning

confidence: 61%

Helicobacter pylori and extragastric diseases

Goni

Franceschi

2016

Helicobacter

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During the past year, many articles were published on the extragastric diseases related to Helicobacter pylori infection. This supports the theory that some microorganisms may cause diseases even far from the primary site of infection by interfering with different biologic processes. The role of H. pylori on idiopathic thrombocytopenic purpura, sideropenica anemia, and vitamin B12 deficiency is well known. On the other hand, there is a growing interest in the bacterium's association with cardiovascular, neurologic, hematologic, dermatologic, head and neck, and uro-gynecologic diseases, as well as diabetes mellitus and metabolic syndrome, with very promising results. This review has been aimed at summarizing the results of the most relevant studies published over the last year on this fascinating topic.

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Section: Hematologic Diseasesmentioning

confidence: 61%

Helicobacter pylori and extragastric diseases

Goni

Franceschi

2016

Helicobacter

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“…First, H. pylori infection may lead to systemic inflammation, and release of cytokines, such as TNF-α, IL-1 and IL-6,45 which may cause bone turnover indirectly. Second, many studies have shown that low vitamin B12 may be associated with H. pylori infection 46. If the serum vitamin B12 levels are decreased, the folate becomes trapped as methyltetrahydrofolate and interrupts for folate-related DNA synthesis, which is an important factor for bone remodelling.…”

Section: Discussionmentioning

confidence: 99%

Relationship betweenHelicobacter pyloriinfection and osteoporosis: a systematic review and meta-analysis

Wang

Zhang³

et al. 2019

BMJ Open

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ObjectivesMany studies have explored the association betweenHelicobacter pyloriinfection and osteoporosis. However, the results remain controversial. Therefore, we performed this systematic review and meta-analysis to evaluate the association betweenH. pyloriinfection and osteoporosis.DesignSystematic review and meta-analysis of case–control studies.Data sourcesDatabases, including PubMed, Embase, Web of Science and Chinese Biomedical Literature Database, were screened from inception to 30 April 2018.Eligibility criteriaCase–control studies aimed at assessing the association betweenH. pyloriinfection and osteoporosis.Data extraction and analysisStudy characteristics and study quality sections were reviewed. Studies were selected, and data were extracted by two reviewers. Pooled ORs and 95% CIs were calculated using random effects model if heterogeneity existed; otherwise, fixed effects model was used. Subgroup analyses were performed to explore the source of heterogeneity. Publication bias and sensitivity analyses were also tested.ResultsA total of 21 studies with 9655 participants were included in our analyses. Taking together, we found thatH. pyloriinfection was associated with increased odds of osteoporosis (OR (95% CI): 1.39 (1.13 to 1.71)); there was no significant difference between osteoporosis and osteopaenia; the association between osteoporosis andH. pyloriinfection was relatively higher in men than women but did not reach significant level. However, the decrease of bone mineral density inH. pylori-positive patients was not significant when compared withH. pylorinegative controls, which may due to the sample size.ConclusionsOur meta-analysis suggests an association between osteoporosis andH. pyloriinfection. The clinicians should pay more attention to the patients infected withH. pylori. Further studies were still needed to exploring the confounding factors among studies and to elucidate the underlying biological mechanisms.

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“…The hypochlorhydric stomach affects calcium absorption, calcium homeostasis and bone mass [ 17 ]. In addition, the low serum vitamin B12 level was found in the patients with H. pylori infection [ 18 ]. If the serum vitamin B12 levels are low, the folate becomes trapped as methyltetrahydrofolate and then interrupts for folate-related DNA synthesis.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Helicobacter pylori infection and bone mineral density: a retrospective cross-sectional study

et al. 2018

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BackgroundHelicobacter pylori (H. pylori) infection can induce individual inflammatory and immune reactions which associated with extra-digestive disorders. Our aim is to investigate the association between H. pylori infection and bone mineral density.MethodsThis retrospective cross-sectional study was performed by using the data from the health examination database in a medical center of southern Taiwan in 2013. We investigated the relationship between sex, age, body mass index (BMI), waist circumstance, lipid profile, H. pylori infection, the findings of upper gastrointestinal endoscopy and bone mineral density (BMD). Because of nonrandomized assignment and strong confounding effect of age on BMD, the 1:1 propensity score match was applied for age adjustment. The simple and multiple stepwise logistic regression analysis were performed to assess the risk factors of decreased BMD in these well-balanced pairs of participants.ResultsOf the 867 subjects in final analysis with the mean age of 55.9 ± 11.3 years, 381 (43.9%) subjects had H. pylori infection, and 556 (64.1%) subjects had decreased BMD. In decreased BMD group, the portion of woman was higher than a normal BMD group (37.2% versus 29.6%, P = 0.023), the age was significantly older (59.4 ± 9.8 versus 49.8 ± 11.3, p < 0.001) and BMI was significantly lower (24.7 ± 3.5 versus 25.4 ± 3.7, p = 0.006) than the normal BMD group. The prevalence of H. pylori infection was 39.9% and 46.2% in the normal BMD group and the decreased BMD group respectively (P = 0.071). The multivariate analysis which was used for these possible risk factors showed that only advanced age (OR 1.09, 95% CI 1.08–1.11, P < 0.001), and low BMI (OR 0.91, 95% CI 0.87–0.95, P < 0.001) were independently significantly associated with decreased BMD in this nonrandomized study. In the propensity score-matched participants, the multiple stepwise logistic regression analysis revealed H. pylori infection (OR 1.62, 95% CI 1.12–2.35, P = 0.011) and low BMI (OR 0.92, 95% CI 0.87–0.97, P = 0.001) were independently significantly associated with decreased BMD.ConclusionsH. pylori infection and low BMI were independently significantly associated with decreased BMD in selected propensity score-matched populations after age adjustment.

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Factors related to low serum vitamin B₁₂ levels in elderly patients with non‐atrophic gastritis in contrast to patients with normal vitamin B₁₂ levels

Cited by 11 publications

References 26 publications

Helicobacter pylori and extragastric diseases

Helicobacter pylori and extragastric diseases

Relationship betweenHelicobacter pyloriinfection and osteoporosis: a systematic review and meta-analysis

Relationship between Helicobacter pylori infection and bone mineral density: a retrospective cross-sectional study

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Factors related to low serum vitamin B12 levels in elderly patients with non‐atrophic gastritis in contrast to patients with normal vitamin B12 levels

Cited by 11 publications

References 26 publications

Helicobacter pylori and extragastric diseases

Helicobacter pylori and extragastric diseases

Relationship betweenHelicobacter pyloriinfection and osteoporosis: a systematic review and meta-analysis

Relationship between Helicobacter pylori infection and bone mineral density: a retrospective cross-sectional study

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Product

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Factors related to low serum vitamin B₁₂ levels in elderly patients with non‐atrophic gastritis in contrast to patients with normal vitamin B₁₂ levels