Factors related to lymph node harvest: does a recovery of more than 12 improve the outcome of colorectal cancer?

Moro‐Valdezate, David; Plá-Martí, Vicente; Martín-Arévalo, José; Belenguer-Rodrigo, J.; Aragó-Chofre, P.; Ruiz-Carmona, María Dolores; Checa-Ayet, Félix

doi:10.1111/codi.12424

Cited by 28 publications

(34 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, T-classification and higher tumor stage were significantly associated with higher lymph node count. Both associations are in the line with literature data showing associations of lymph node retrieval with T-classification [13, 21, 23, 32] and AJCC/UICC stage [11, 13, 14, 21, 32–35]. Also, tumor size is, according to previous studies, an established predictor of lymph node yield [11, 13, 23, 29, 31, 36] that could be confirmed by our study.…”

Section: Discussionsupporting

confidence: 93%

See 1 more Smart Citation

Lymph node retrieval in colorectal cancer: determining factors and prognostic significance

Betge

Harbaum

Pollheimer

et al. 2017

Int J Colorectal Dis

View full text Add to dashboard Cite

PurposeThe study aimed to analyze clinicopathological factors that determine the extent of lymph node retrieval and to evaluate its prognostic impact in patients with colorectal cancer (CRC).MethodsThe number of retrieved lymph nodes was analyzed in 381 CRC specimens. Lymph node count was related to different clinicopathological variables by binary logistic regression. Progression-free survival (PFS) and cancer-specific survival (CSS) were determined using the Kaplan-Meier method and Cox regression models.ResultsThe median number of retrieved lymph nodes was 20 (mean 21 ± 10, range 1–65) in right-sided, 13 (16 ± 10, 1–66) in left-sided, and 15 (18 ± 11, 3–64) in rectal tumors. The number of retrieved lymph nodes was independently associated with T-classification (p < 0.001), N-classification (p = 0.014), and tumor size (p = 0.005) as well as right-sided tumor location (p = 0.012). There was no association with age, sex, tumor grade, mismatch-repair status, and lymph or blood vessel invasion. The longer the surgical specimen, the higher were the numbers of retrieved and positive lymph nodes (p < 0.001, respectively). In patients with locally advanced (T3/T4) tumors (n = 283), analysis of more than 12 lymph nodes was independently associated with PFS (HR = 0.63, p = 0.025) and CSS (HR = 0.54, p = 0.004). In the subset of T3/T4 N0 patients (n = 130), analysis of more than 12 lymph nodes similarly proved to be an independent predictor of outcome (PFS, HR = 0.48, p = 0.046; OS, HR = 0.41, p = 0.026).ConclusionThe number of retrieved lymph nodes is associated with higher tumor stage, tumor size, and right-sided location. Low lymph node count indicates adverse outcome in patients with locally advanced (T3/T4) disease.

show abstract

Section: Discussionsupporting

confidence: 93%

“…Also, since several studies failed to prove prognostic impact [13–15, 34, 36, 40]. These negative results may be due to different methodologies and heterogeneous study populations including different stages, both colon and rectum cancers, different cut-off values, but also small sample sizes.…”

Section: Discussionmentioning

confidence: 99%

Lymph node retrieval in colorectal cancer: determining factors and prognostic significance

Betge

Harbaum

Pollheimer

et al. 2017

Int J Colorectal Dis

View full text Add to dashboard Cite

show abstract

“…Adequate resection of LNs in surgery of CRC is an important factor in tumor staging. Several factors have been shown to have a positive correlation with the number of LNs harvested, such as patient age <60 years, right‐sided tumor location, advanced tumor stage, longer length of resected bowel segment, and expertise of the pathologist and surgeon . In this study, the median numbers of LNs harvested were 26 in the laparoscopic and 20 in the open group.…”

Section: Discussionmentioning

confidence: 60%

Laparoscopic surgery for patients with colorectal cancer produces better short‐term outcomes with similar survival outcomes in elderly patients compared to open surgery

et al. 2016

View full text Add to dashboard Cite

The number of operations on elderly colorectal cancer (CRC) patients has increased with the aging of the population. The aim of this study was to evaluate surgical outcomes in elderly patients who underwent laparoscopic or open surgery for CRC. We analyzed the data of 280 patients aged 80 or over who underwent surgery for CRC between January 2001 and December 2010. Seventy‐one pairs were selected after propensity score matching for laparoscopic or open surgery. Operative time, return to normal bowel function, length of hospital stay, postoperative complications, overall survival (OS), recurrence‐free survival (RFS), and prognostic factors affecting survival were investigated. In matched cohorts, operative time in the laparoscopic group was longer than in the open group (P < 0.001). In the laparoscopic group, time to flatus passage (P < 0.001) and length of postoperative hospital stay (P = 0.037) were shorter than in the open group. The rate of operation‐related morbidity was higher in the open group (P = 0.019). There was no difference in OS and RFS between two groups. This study suggests that laparoscopic surgery for CRC in elderly patients may be safe and feasible, with better short‐term outcomes. OS and RFS, however, were not different in both groups.

show abstract

“…The histopathological variables assessed, defined in terms of undesirable outcomes, were traumatically disrupted perirectal fascial envelope as determined macroscopically by the surgeon from the fresh, unopened operative specimen; tumor at or within 1 mm of the circumferential line of resection; a lymph node yield less than 12; and a distal margin of less than 1 cm …”

Section: Methodsmentioning

confidence: 99%

Pathological outcomes in rectal cancer following laparoscopic surgery

Cheung

Dent

Richardson

et al. 2017

Asia-Pac J Clncl Oncology

View full text Add to dashboard Cite

show abstract

Factors related to lymph node harvest: does a recovery of more than 12 improve the outcome of colorectal cancer?

Cited by 28 publications

References 22 publications

Lymph node retrieval in colorectal cancer: determining factors and prognostic significance

Lymph node retrieval in colorectal cancer: determining factors and prognostic significance

Laparoscopic surgery for patients with colorectal cancer produces better short‐term outcomes with similar survival outcomes in elderly patients compared to open surgery

Pathological outcomes in rectal cancer following laparoscopic surgery

Contact Info

Product

Resources

About