Factors related to nephrotic-range proteinuria in late-stage chronic kidney disease patients with diabetes mellitus

Abstract

Higher systolic blood pressure, serum phosphorus, and triglyceride levels are associated with nephrotic-range proteinuria in patients with diabetic nephropathy and CKD stage 3-5. Further studies should clarify whether a reduction in serum phosphorus would lead to a decrease in proteinuria in these patients.

Nephrotic range proteinuria as a strong risk factor for rapid renal function decline during pre-dialysis phase in type 2 diabetic patients with severely impaired renal function

“…This is probably because the number of patients included in this study was relatively small. Recently, even mild elevation of systolic blood pressure beyond 121 mmHg was shown to be strongly associated with nephrotic range proteinuria in diabetic patients with severely impaired renal function [22]. Furthermore, a previous study has shown that aggressive antihypertensive treatment could lead to remission of nephrotic range proteinuria and slowed down the progression of nephropathy [10].…”