Factors Related to Pulse Wave Velocity and Augmentation Index in Chronic Hemodialysis Patients

Çelik, Gülperi; Demirci, Meltem Seziş; Tümüklü, Murat; Aşçı, Gülay; Sipahi, Savaş; Töz, Hüseyin; Başçı, Alı; Ok, Ercan

doi:10.3109/0886022x.2011.615967

Cited by 3 publications

(2 citation statements)

References 40 publications

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“…In hemodialysis patients, atherosclerotic changes, calcifications, and impaired coronary endothelial function may lead to coronary microvascular and epicardial vascular dysfunction and consequently to chronic myocardial ischemia . Increased aortic stiffness is also very common in these patients and may also contribute to impaired left ventricular function and myocardial ischemia …”

Section: Introductionmentioning

confidence: 99%

Impaired coronary microcirculation is associated with left ventricular diastolic dysfunction in end‐stage chronic kidney disease patients

et al. 2020

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Introduction: Coronary vascular dysfunction, as assessed by coronary flow reserve (CFR) in the left anterior descending coronary artery, is found in various conditions including end-stage chronic kidney disease (CKD). Currently, we investigated the associations of CFR with echocardiographic indices of systolic and diastolic cardiac function and identified independent predictors of CFR in hemodialysis patients. Methods: End-stage CKD patients treated with hemodialysis (n = 29) without known cardiovascular disease were recruited from a Hemodialysis Unit in Northwestern Greece. A thorough echocardiographic evaluation including CFR measurement following dipyridamole infusion was performed in all participants. Arterial stiffness was assessed by measurement of carotid-femoral pulse wave velocity and aortic augmentation index. Results: The mean age of the patients was 63 years, and mean duration of hemodialysis was 2.9 years. CFR was 1.60 ± 0.37 while dipyridamole caused a significant increase in E' sep , S lat , E' lat , and Stroke volume (P < .05 for all). Independent predictors of CFR were posterior wall thickness (B −0.408, P = .013) and dipyridamole-induced changes in Tei index (B −0.425, P = .007). A severely decreased CFR < 1.5 was observed in 52% of the patients. E/E' ratio (B 10.84, P = .014) was the single independent predictor of severely decreased CFR. Conclusions: In end-stage CKD patients on hemodialysis without known cardiovascular disease, impaired coronary vascular function was prevalent and related to increased left ventricular wall thickness, increased filling pressures, and dipyridamole-induced deteriorated myocardial function independently of the presence of wall-motion abnormalities. Further studies are required to clarify the prognostic role of dipyridamole-induced cardiac changes in hemodialysis patients. K E Y W O R D S coronary flow reserve, diastolic function, echocardiography, end-stage renal disease, left ventricular function | 537 PAPAMICHAIL et AL.

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Section: Introductionmentioning

confidence: 99%

Impaired coronary microcirculation is associated with left ventricular diastolic dysfunction in end‐stage chronic kidney disease patients

et al. 2020

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“…When adjusted to a standard heart rate of 75 beats•min -1 , AIx is denoted as AIx@75. AIx is used as a measure of arterial stiffness [2] [3]. Arterial stiffness is considered to be a marker of subclinical vascular disease and an independent predictor of coronary heart disease and stroke in apparently healthy individuals [4] and a predictor of mortality in symptomatic individuals [5].…”

Section: Introductionmentioning

confidence: 99%

Cardiovagal Tone: A Predictor of Heart Rate Adjusted Augmentation Index in Men but Not in Women

Latchman¹,

Thiel²,

Gates³

et al. 2017

OJMIP

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Purpose: Aortic augmentation index (AIx) and cardiovagal tone (CVT) are indicators of cardiovascular health. Associations between these variables provide information about their roles in cardiovascular disease. However, evaluating these associations from a gender perspective and gaining an understanding of the relationship between cardiorespiratory fitness and AIx based on gender can provide additional information. Therefore, we examined the relationships between CVT, measured as the log transformed high-frequency power of R-R intervals from electrocardiogram measurements (lnHF R-R ); cardiorespiratory fitness, measured as maximum oxygen consumption (VO 2 max); and AIx at a heart rate of 75 beats•min -1 (AIx@75). We hypothesized that the relationships between CVT, cardiorespiratory fitness, and AIx@75 would differ based on gender. Methods: We examined the associations between lnHF R-R , VO 2 max, and AIx@75 in 41 women and 39 men. Power spectral density analysis of heart rate variability determined lnHF R-R , radial tonometry determined AIx@75 and the Bruce Treadmill Protocol determined VO 2 max. Results: In men, lnHF R-R positively correlated with and significantly predicted AIx@75 (P = 0.005) but not in women (P = 0.49). For every unit increase in lnHF R-R , there was a 4.6 unit increase in AIx@75 in men versus a 1.0 unit increase in women. There was a significant inverse relationship between VO 2 max and AIx@75, with VO 2 max being a significant predictor of AIx@75 in men (P = 0.01). For every unit increase in VO 2 max, there was a 0.60 unit decrease in AIx@75 in men versus a 0.2 unit decrease in women. Conclusions: The associations beHow to cite this paper: Latchman, P.L., Thiel, R., Gates, G., Zhu, W.L., Axtell, R., Gardner, K., Lunn, W. and DeMeersman, R.

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Aortic pulse wave velocity in haemodialysis patients is associated with the prescription of active vitamin D analogues

Charitaki

Davenport

2014

J Nephrol

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Factors Related to Pulse Wave Velocity and Augmentation Index in Chronic Hemodialysis Patients

Cited by 3 publications

References 40 publications

Impaired coronary microcirculation is associated with left ventricular diastolic dysfunction in end‐stage chronic kidney disease patients

Impaired coronary microcirculation is associated with left ventricular diastolic dysfunction in end‐stage chronic kidney disease patients

Cardiovagal Tone: A Predictor of Heart Rate Adjusted Augmentation Index in Men but Not in Women

Aortic pulse wave velocity in haemodialysis patients is associated with the prescription of active vitamin D analogues

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