Factors related to retinal nerve fiber layer thickness in bipolar disorder patients and major depression patients

Liu, Yanhong; Tong, Yongsheng; Huang, Lvzhen; Chen, Jingxu; Yan, Shaoxiao; Yang, Fang

doi:10.1186/s12888-021-03270-7

Cited by 14 publications

(12 citation statements)

References 22 publications

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“…In the past, in individuals with MD, the retinal structure using the OCT test examination was investigated in 5 case-control studies with mixed results. 14,[38][39][40][41][42] Jung et al described decrease of ganglion cell inner plexiform layer thickness in individuals with MD. 12 Kalenderoglu et al showed significantly reduced GCL, IPL, and global and temporal superior retinal nerve fiber layer (RNFL) thickness in the recurrent-MD individuals compared to the first-episode individuals, and in all MD individuals compared with the controls.…”

Section: Discussionmentioning

confidence: 99%

“…42 However, other researchers, like in our study comparing the MD individuals with the healthy controls, found no statistically significant differences in the OCT measures. [39][40][41] The feature of abnormal ISCEV-standard PVEPs response has clinical relevance. The PVEPs signal might serve as an objective marker of the major depression and has a potential value in monitoring pharmacological and nonpharmacological treatment trials.…”

Section: Discussionmentioning

confidence: 99%

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Visual pathway function in untreated individuals with major depression

Lubiński¹,

Grabek-Kujawa²,

Mularczyk³

et al. 2023

Adv Clin Exp Med

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Background. Major depression (MD) is the one of the most debilitating diseases, affecting millions of people all around the world.Objectives. To establish visual pathway function in untreated individuals with MD. Materials and methods.In 29 untreated, newly diagnosed, ophthalmologically asymptomatic individuals (58 eyes) with MD (mean age: 47.3 years) and in 29 (58 eyes) of age-, sex-and refractive error-matched healthy controls (mean age: 46.8 years), the following examinations were performed: 1) best corrected distance visual acuity (BCDVA); 2) intraocular pressure (IOP); 3) and 4) biomicroscopy of anterior and posterior segment of eye; 5) macular structure (SD-OCT-Zeiss); and 6) pattern visual evoked potentials (PVEPs) measurements according to the International Society for Clinical Electrophysiology of Vision (ISCEV) standard (ISCEV-standard PVEPs). An analysis of correlation between the parameters of PVEPs and the depression severity (Hamilton Depression Rating Scale (HAMD)) was performed. To estimate the diagnostic power of PVEPs test, a receiver operating characteristics (ROC) curve was used. Data were analyzed with the significance level of p < 0.05.Results. In the study group and in healthy control, the clinical results and macular structure were normal and not different. In the MD group, in PVEPs test (check size: 1°4'and 0°16'), a significant decrease of amplitudes of P100 (AP100), associated with prolonged P100 peak time (PTP100; check size: 0°16' , p < 0.004) were detected. The most frequent abnormality in PVEPs examination in the MD group was AP100 reduction (in 69% of individuals) detected using stimulation check size 0°16' . The statistically significant positive correlation between PTP100 (check size: 0°16') and HAMD score was found in severe MD (p = 0.03). The analysis of ROC curve revealed the highest sensitivity of 0.759 and specificity of 1.0 for AP100 (0°16'). The area under the curve (AUC) was 0.841 (p < 0.001). Conclusions.In individuals with newly diagnosed, ophthalmologically asymptomatic and untreated MD, a dysfunction of visual pathway is present without other signs of ocular pathology. The visual pathway dysfunction measured with ISCEV PVEPs has a potential value to be an objective biomarker of MD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Visual pathway function in untreated individuals with major depression

Lubiński¹,

Grabek-Kujawa²,

Mularczyk³

et al. 2023

Adv Clin Exp Med

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“…Studies have employed OCT to reveal that patients with bipolar disorder have thinner RNFL compared with healthy controls,26 which has also been linked to disease duration 27. Age at onset and alanine aminotransferase (ALT) could be potential protective factors in the progress of RNFL thinning, whereas uric acid is a pathological factor in patients with bipolar disorder 28. Studies have also adopted OCT to reveal marked RNFL and macula lutea thinning in patients with MDD relative to normal people 28.…”

Section: Discussionmentioning

confidence: 99%

Role of optical coherence tomography in depression detection: a protocol of systematic review and meta-analysis

et al. 2023

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IntroductionOptical coherence tomography (OCT) is a non-invasive approach for detecting changes in the retinal layers, which may also reflect changes in brain structure and function. As one of the leading causes of disability worldwide, depression has been associated with alteration of brain neuroplasticity. However, the role of OCT measurements in detecting depression remains unknown. This study aims to employ a systematic review and meta-analysis approach to explore ocular biomarkers measured by OCT for detecting depression.Methods and analysisWe will search studies describing the relationship between OCT and depression across seven electronic databases, and retrieve articles published from database inception to date. We will also manually search grey literature and reference lists included in the retrieved studies. Two independent reviewers will screen studies, extract data and assess risk of bias. Target outcomes will include peripapillary retinal nerve fibre layer thickness, macular ganglion cell complex thickness and macular volume, as well as other related indicators. Next, we will conduct subgroup analysis and meta-regression to explore study heterogeneity, then perform sensitivity analysis to investigate the robustness of the synthesised results. Meta-analysis will be performed using Review Manager (V.5.4.1) and STATA (V.12.0), and the certainty of evidence will be graded according to the Grading of Recommendations Assessment, Development and Evaluation system.Ethics and disseminationEthics approval is not necessary because the data used in this systematic review and meta-analysis will be extracted from published studies. Study results will be disseminated by publishing our findings in a peer-reviewed journal.

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“…As a neurodegenerative disease, the diagnosis of MDD mainly relies on the patient’s subjective assessment and lacks quantifiable objective indicators. Although previous studies have demonstrated the structural alterations of the retina in MDD patients, such as thinner RNFLT ( 36 ), reduced minimum ganglion cell-inner plexiform layer and poor visual function ( 37 ), a highly reliable retinal-related indicators for screening of early-stage MDD remains to be identified for the following reasons. First, previous research indicators on the retina of MDD patients are relatively single, mostly focusing on retinal thickness, and a comprehensive and systematic analysis of the retina is lacking.…”

Section: Discussionmentioning

confidence: 99%

Development of a Novel Retina−Based Diagnostic Score for Early Detection of Major Depressive Disorder: An Interdisciplinary View

Liu

Lai

et al. 2022

Front. Psychiatry

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BackgroundClinically effective markers for the diagnosis of major depressive disorder (MDD) are lacking. Alterations in retinal features are closely related to the pathophysiological progression of MDD. However, the reliable retina-related diagnostic model for MDD remains to be developed. Thus, our study aimed to quantitatively evaluate retinal vascular and structural changes in MDD patients and to develop a reliable diagnostic model of MDD based on retinal parameters.MethodsSeventy-eight patients with MDD and 47 healthy controls (HCs) underwent retinal vessel density and structure examination using optical coherence tomography angiography and visual field examination using perimetry. Independent-sample t test was used to assess the differences in retinal parameters between the groups. Meanwhile, we constructed the corresponding retina-based diagnostic model by LASSO logistic regression. Finally, the diagnostic ability of the model was evaluated by area under the curve (AUC) of receiver operating characteristic curves and calibration plot of nomogram.ResultsMDD patients showed lower retinal vessel density (including radial peripapillary capillary vessel density, superficial and deep capillary plexus vessel density), thinner subfoveal choroidal thickness, and poorer visual fields compared to HCs (all p < 0.05). Furthermore, a retina-based diagnostic model was constructed and shows a strong diagnostic capability for MDD (AUC = 0.9015, p < 0.001).ConclusionPatients with MDD showed distinct retinal features compared to HCs. The retina-based diagnostic model is expected to be a necessary complement to the diagnosis of MDD.

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Factors related to retinal nerve fiber layer thickness in bipolar disorder patients and major depression patients

Cited by 14 publications

References 22 publications

Visual pathway function in untreated individuals with major depression

Visual pathway function in untreated individuals with major depression

Role of optical coherence tomography in depression detection: a protocol of systematic review and meta-analysis

Development of a Novel Retina−Based Diagnostic Score for Early Detection of Major Depressive Disorder: An Interdisciplinary View

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