Factors related to survival following resection for gastric carcinoma.Analysis of 903 cases

Serlin, Oscar; Keehn, Robert J.; Higgins, George A.; Harrower, Harold W.; Mendeloff, Gale L.

doi:10.1002/1097-0142(197709)40:3<1318::aid-cncr2820400349>3.0.co;2-9

Cited by 59 publications

(7 citation statements)

References 6 publications

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“…As shown in previous studies based on univariate and multivariate analyses, T-stage, lymph-node involvement and vascular invasion are the most important histological parameters predicting the prognosis of gastric cancer patients (Serlin et al, 1977;Okada et al, 1983;Curtis et al, 1985;Miwa, 1984;Maruyama, 1987;Bozzetti et al, 1990;Gabbert et al, 1991). When these parameters were compared with the prognostic value of TCD, T-stage, followed by vascular invasion and lymph-node involvement were the histological parameters of highest prognostic value in our study, too.…”

Section: Discussionsupporting

confidence: 77%

Tumor‐cell dissociation at the invasion front: A new prognostic parameter in gastric cancer patients

Gabbert

Meier

Gerharz

et al. 1992

Intl Journal of Cancer

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Tumor-cell dissociation (TCD) is a well-known feature at the invasion front of malignant tumors, but little attention has so far been paid to its biological significance. Therefore, the aim of the present study was to score the degree of TCD at the invasion front (TCD 0-3) in a retrospective series of 445 gastric cancer patients and to compare its prognostic significance with the parameters T-stage, tumor size, grade of tumor differentiation, lymph-node involvement and vascular invasion. We could show that highly significant differences (p less than 0.0001, log-rank test) existed between the 5-year survival rates of patients with different degrees of TCD (TCD 0: 92.3%; TCD 1: 62.1%; TCD 2: 41.2%. TCD 3:38.5%) and that these differences were independent of T-stage 2, tumor size and grade of tumor differentiation. Univariate Cox regression analysis showed that in intestinal-type carcinomas, T-stage (Chi-square: 45.2) followed by blood vessel and lymphatic vessel invasion (Chi-square: 43.6 and 40.0) had the highest prognostic value, whereas TCD (Chi-square: 31.5) revealed a prognostic value quite similar to that of lymph-node involvement (Chi-square: 35.1). This prognostic relevance was still present in multivariate Cox regression analysis, showing that the determination of TCD provided an increase in prognostic information which significantly (P = 0.026) exceeded the information obtained by the combination of T-stage and lymph-node involvement. Our data suggest that TCD is a new prognostic parameter, especially in those gastric carcinomas in which lymph-node involvement or vascular invasion are not present.

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Section: Discussionsupporting

confidence: 77%

Tumor‐cell dissociation at the invasion front: A new prognostic parameter in gastric cancer patients

Gabbert

Meier

Gerharz

et al. 1992

Intl Journal of Cancer

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“…Also of those that had TNM staging, 57.9% were stage II. These findings seen to suggest poor outcome, and thus support studies that found that, the deeper the penetration of the gastric wall by tumour the greater the chance of metastases and hence the poorer the prognosis [26][27][28].…”

Section: Colorectal Cancerssupporting

confidence: 81%

Anatomic categorization of gastrointestinal malignancies using haematoxylin and eosin stains A 10 year retrospective histopathological study at the Korle Bu Teaching Hospital Accra

Em¹

2015

J Cancer Res Ther.

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The global burden of cancer continues to increase in both developed (high income) and developing (low-middle income) countries largely because of increasing life expectancy and growth of the world population as well as the adoption of cancer-causing behaviors, in the lowmiddle income countries, particularly smoking [1-6]. The population of Ghana is aging and this has led to an increased morbidity and mortality [6, 7]. Malignancies of the gastrointestinal (GI) tract are more common in the elderly (65 years and above) [8-10], but are rare in infancy, childhood and adolescence [11-12]. Some studies have shown that gastrointestinal (GI) malignancies are commoner in males than females [13-14] and depending on the anatomic location, majority of gastrointestinal cancers are diagnosed from the colon and rectum [11, 14]. Clinical presentation is usually late, with symptoms such as abdominal mass, ascites, bleeding per rectum,

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“…Although adjuvant therapy after radical ~astric resection has been expected to be the most promising treatment for stomach cancer, there is no long-term follow-up report to demonstrate improvement of survival with use of adjuvant therapy and many pessimistic results [34,35] have been reported !nstead. Several regimens for adjuvant chemotherapy have been suggested and evaluated clinically.…”

Section: Resultsmentioning

confidence: 99%

The concept of immunochemosurgery in gastric cancer

Kim

1987

World j. surg.

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To evaluate the effectiveness of adjuvant immunochemotherapy in advanced adenocarcinoma of the stomach, patients who had undergone radical subtotal gastrectomy for stage III gastric carcinoma were randomized to receive immunochemotherapy or not. For immunotherapy,Streptococcus pyogenes preparation (picibanil) was given intramuscularly every week, and for chemotherapy, either MFC (mitomycin C, 5‐fluorouracil, and cytosine arabinoside) regimen or FME (5‐fluorouracil and methyl‐CCNU) regimen was given. Immunotherapy was started at the fourth or fifth postoperative day and chemotherapy was started at the eighth to tenth postoperative day. To evaluate the immune status of patients, various immune parameters such as 1‐chloro‐2, 4‐dinitrobenzene (DNCB) test, T‐lymphocyte count, PHA‐ and concanavalin‐A‐stimulated lymphoblastogenesis, and antibody‐dependent cellular cytotoxicity (ADCC) activity were checked before surgery and 3–4 months postoperatively. One hundred and thirty‐eight patients were chosen for study during a 5‐year period. Seventy‐four patients received postoperative immunochemotherapy and 64 patients received no further anticancer therapy following their operation. All patients had been followed for at least 5 years since they underwent surgery. Survival rate and immune status were compared between the 2 groups. Patient characteristics and preoperative values for the immune status of the 2 groups were similar to each other. The 5‐year survival rate of the postoperative immunochemotherapy group was 44.6%, whereas that of the surgery alone group was 23.4%. The difference is statistically significant (p<0.05). All the postoperative values of immune parameters showed more favorable data in the postoperative immunochemotherapy group. Postoperative immunochemotherapy is no longer adjuvant, but is an essential systemic therapy to prolong patient survival and cure disease. This author proposes to use the termimmunochemosurgery instead of “surgery and adjuvant immunochemotherapy” for gastric cancer.

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Factors related to survival following resection for gastric carcinoma.Analysis of 903 cases

Cited by 59 publications

References 6 publications

Tumor‐cell dissociation at the invasion front: A new prognostic parameter in gastric cancer patients

Tumor‐cell dissociation at the invasion front: A new prognostic parameter in gastric cancer patients

Anatomic categorization of gastrointestinal malignancies using haematoxylin and eosin stains A 10 year retrospective histopathological study at the Korle Bu Teaching Hospital Accra

The concept of immunochemosurgery in gastric cancer

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